Simultaneous Photoacoustic and Laser‐Induced Ultrasound Imaging of Animals and Humans via a Semi‐Transparent Ultrasound Transducer DOI Creative Commons

Bjarne Perleberg,

Sangmin Lee, Preeti Malik

et al.

Laser & Photonics Review, Journal Year: 2025, Volume and Issue: unknown

Published: May 21, 2025

Abstract Combined photoacoustic (PA) and ultrasound (US) imaging, a promising modality for preclinical clinical studies, can provide anatomical, physiological, molecular information about biological tissues. However, common implementations of US imaging require an external pulser to transmit waves, which makes integrated PA/US systems relatively complicated suboptimal. Here, without using pulser, simultaneous PA laser‐induced (LUS) is demonstrated through semi‐transparent transducer (sTUT). Some portion excitation laser energy converted waves when the beam passes sTUT, transmitting focused targets. The other light directly delivered tissues generate signals. This bimodal approach not only eliminates need electrical‐pulser but also allows sTUT be incorporated with preamplifier increase signal‐to‐noise ratio. Further, light, compact easily as part handheld PA/LUS system in vivo studies small animals humans. it photoacoustically ultrasonically visualize different structures functions human skin structures. simplified microscopic has great potential broadband studies.

Language: Английский

A Clinical Feasibility Study of a Photoacoustic Finder for Sentinel Lymph Node Biopsy in Breast Cancer Patients: A Prospective Cross-Sectional Study DOI Creative Commons
Moongyu Han,

Youngjoo Lee,

Junho Ahn

et al.

Photoacoustics, Journal Year: 2025, Volume and Issue: unknown, P. 100716 - 100716

Published: March 1, 2025

The sentinel lymph node (SLNb) is generally performed using radioisotopes, blue dyes, or both to improve false negative rate. However, ionizing radiation involved in a gamma probe with radioisotopes and the dye detection relies on native visual inspection by an operator. To overcome these limitations, we developed photoacoustic finder (PAF), highly sensitive, non-radioactive detector that uses only signal detect SLNs. A total of 121 patients breast cancer were enrolled, 375 nodes excised conventional SLNb. PAF was used measure from nodes. We compared SLN rates each method (gamma probe, inspection, PAF) conducted non-inferiority test. detected 87 % SLNs, comparable (85 %) superior (73 %). Non-inferiority tests confirmed PAF's performance not inferior (p < 0.001) 0.015). Using dual-modal + inspection) as gold standard, showed sensitivity 0.81 specificity 0.63. This study demonstrates PAF, dye, offers non-inferior alternative standard radioactive materials, opening new avenues for radiation-free SLNb future.

Language: Английский

Citations

1
In Vivo 3D Photoacoustic and Ultrasound Analysis of Hypopigmented Skin Lesions: A Pilot Study DOI Creative Commons
Minseong Kim, Ju Hee Han, Junho Ahn

et al.

Photoacoustics, Journal Year: 2025, Volume and Issue: 43, P. 100705 - 100705

Published: March 8, 2025

Vitiligo needs early identification for proper intervention. Current adjunct diagnostic methods rely mostly on subjective visual inspection. Thus, of or atypical vitiligo lesions among other hypopigmentation disorders may pose challenges. To overcome this, we investigate the feasibility a three-dimensional (3D) photoacoustic (PA) and ultrasound (US) imaging technique as new adjuvant analytic tool providing quantitative characterization features. This cross-sectional study was conducted at Seoul St. Mary's Hospital (Seoul, Republic Korea) between August 2022 January 2024. Lesions diagnosed IGH in locations that could safely be irradiated with laser were analyzed 3D PA/US along conventional methods. A total 53 consisted 36 17 from 39 participants confirmed diagnosis analyzed. The PA amplitude greatly differed normal skin lesions, mean amplitudes slightly higher than [mean (standard deviation, SD): vitiligo: 0.117 (0.043); IGH: 0.135 (0.028)]. local SD [vitiligo: 0.043 (0.018); 0.067 (0.017)]. slope across lesion boundary significantly 0.173 (0.061); 0.342 (0.099)], whereas peak depth deeper 0.568 (0.262); 0.266 (0.116)]. Unlike qualitative methods, can non-invasively provide metrics which might aid differentiation lesions.

Language: Английский

Citations

0
Local Oxygen Concentration Reversal from Hyperoxia to Hypoxia Monitored by Optical-Resolution Photoacoustic Microscopy in Inflammation-Resolution Process DOI Creative Commons

Yizhou Tan,

Min Zhang,

Zhifeng Wu

et al.

Photoacoustics, Journal Year: 2025, Volume and Issue: unknown, P. 100730 - 100730

Published: May 1, 2025

Language: Английский

Citations

0
Simultaneous Photoacoustic and Laser‐Induced Ultrasound Imaging of Animals and Humans via a Semi‐Transparent Ultrasound Transducer DOI Creative Commons

Bjarne Perleberg,

Sangmin Lee, Preeti Malik

et al.

Laser & Photonics Review, Journal Year: 2025, Volume and Issue: unknown

Published: May 21, 2025

Abstract Combined photoacoustic (PA) and ultrasound (US) imaging, a promising modality for preclinical clinical studies, can provide anatomical, physiological, molecular information about biological tissues. However, common implementations of US imaging require an external pulser to transmit waves, which makes integrated PA/US systems relatively complicated suboptimal. Here, without using pulser, simultaneous PA laser‐induced (LUS) is demonstrated through semi‐transparent transducer (sTUT). Some portion excitation laser energy converted waves when the beam passes sTUT, transmitting focused targets. The other light directly delivered tissues generate signals. This bimodal approach not only eliminates need electrical‐pulser but also allows sTUT be incorporated with preamplifier increase signal‐to‐noise ratio. Further, light, compact easily as part handheld PA/LUS system in vivo studies small animals humans. it photoacoustically ultrasonically visualize different structures functions human skin structures. simplified microscopic has great potential broadband studies.

Language: Английский

Citations

0