Substance-use disorders in children and adolescents DOI
Rainer Thomasius, Kerstin Paschke, Nicolas Arnaud

et al.

Deutsches Ärzteblatt international, Journal Year: 2022, Volume and Issue: unknown

Published: June 14, 2022

The most common substance use disorders in childhood and adolescence have to do with alcohol cannabis. These begin as early puberty, are often accompanied by other mental disorders, and, if untreated, very frequently persist into adulthood.This review is based on pertinent publications retrieved a selective search PubMed children adolescents.Substance among the commonest adolescence. In Germany, approximately 10% of adolescents tried cannabis at least once. prognosis negatively affected individual (bio-)psychological traits, comorbidities, laws that facilitate consumption, socioeconomic disadvantage, consuming peers, parental disorders. A timely diagnosis, motivation pediatrician, referral specialized child adolescent psychiatric services helps assure those receive appropriate treatment, goal abstinence from well improvement emotional regulation, affectivity, attention. According studies English-speaking countries considering all treatment forms, completed 60% 65% adolescents; 20% 40% these patients abstinent six months after end treatment. No this type been carried out date Germany.As results generally poor, there major need for research care particular, interfaces between outpatient inpatient further improvement.

Language: Английский

Consequences of adolescent drug use DOI Creative Commons
Michael Steinfeld, Mary M. Torregrossa

Translational Psychiatry, Journal Year: 2023, Volume and Issue: 13(1)

Published: Oct. 6, 2023

Abstract Substance use in adolescence is a known risk factor for the development of neuropsychiatric and substance disorders adulthood. This part due to fact that critical aspects brain occur during adolescence, which can be altered by drug use. Despite concerted efforts educate youth about potential negative consequences use, initiation remains common amongst adolescents world-wide. Additionally, though there has been substantial research on topic, many questions remain predictors adolescent In following review, we will highlight some most recent literature neurobiological behavioral effects rodents, non-human primates, humans, with specific focus alcohol, cannabis, nicotine, interactions between these substances. Overall, consumption substances produce long-lasting changes across variety structures networks have enduring behavior, emotion, cognition.

Language: Английский

Citations

155
The Lancet Psychiatry Commission on youth mental health DOI
Patrick D. McGorry, Cristina Mei,

Naeem Dalal

et al.

The Lancet Psychiatry, Journal Year: 2024, Volume and Issue: 11(9), P. 731 - 774

Published: Aug. 13, 2024

Language: Английский

Citations

107
Alcohol and the Brain DOI Open Access
David Nutt, Alexandra Hayes, Leon Fonville

et al.

Nutrients, Journal Year: 2021, Volume and Issue: 13(11), P. 3938 - 3938

Published: Nov. 4, 2021

Alcohol works on the brain to produce its desired effects, e.g., sociability and intoxication, hence is an important organ for exploring subsequent harms. These come in many different forms such as consequences of damage during from falls fights, withdrawal, toxicity alcohol metabolites altered structure function with implications behavioral processes craving addiction. On top that are peripheral factors compound poor diet, vitamin deficiencies leading Wernicke-Korsakoff syndrome. Prenatal exposure can also have a profound impact development lead irremediable changes fetal This chapter briefly reviews aspects these particular focus recent imaging results. Cardiovascular effects pathology not covered they dealt elsewhere volume.

Language: Английский

Citations

64
Epidemiology and Disease Burden of Alcohol Associated Liver Disease DOI Open Access
Aysha Aslam, Paul Y. Kwo

Journal of Clinical and Experimental Hepatology, Journal Year: 2022, Volume and Issue: 13(1), P. 88 - 102

Published: Sept. 20, 2022

Language: Английский

Citations

58
Adolescent Binge Alcohol Enhances Early Alzheimer’s Disease Pathology in Adulthood Through Proinflammatory Neuroimmune Activation DOI Creative Commons

Alexandra Barnett,

Emeraghi David,

Aaron Rohlman

et al.

Frontiers in Pharmacology, Journal Year: 2022, Volume and Issue: 13

Published: April 26, 2022

Epidemiological studies suggest that heavy alcohol use early in life is associated with increased risk for Alzheimer's disease (AD). However, mechanisms connecting AD have not been identified. Both and feature proinflammatory signaling. Therefore, we hypothesized adolescent binge ethanol would increase molecular behavioral pathology adulthood through The 3xTg-AD mouse model (APPSwe, tauP301, Psen1tm1Mpm) which features amyloid (Aβ) tau beginning at 6-12 months underwent intermittent (AIE, 5 g/kg/d, i.g., P25-55) assessment of pathologic mediators P200. A second group mice received AIE +/- minocycline (30 mg/kg/d, IP) followed by testing adulthood. Behavioral age included: locomotor activity exploration (27-28 weeks), novel object recognition (NORT, 28-30 3-chamber sociability social memory (29-31 prepulse inhibition (PPI, 30-32 Morris Water Maze reversal (MWM, 31-35 Piezo sleep monitoring (35-37 weeks). We found levels neurotoxic Aβ1-42 adult female hippocampus as well intraneuronal amygdala entorhinal cortex. Phosphorylated residue Thr181 (p-tau-181) was also AIE. Several genes were persistently the hippocampus, including IL-1β, MCP-1, IL-6, IFNα. Expression these strongly correlated p-tau-181 hippocampus. caused persistent decreases (open-field NORT habituation) anxiety-like behavior (thigmotaxis) while reducing retention. Treatment anti-inflammatory compound during blocked increases prevented AIE-induced thigmotaxis loss. Together, data find enhances Blockade signaling exposure prevents ethanol-induced effects on accumulation AD-associated proteins changes relevant to human AD.

Language: Английский

Citations

47
Alcohol and stress exposure across the lifespan are key risk factors for Alzheimer's Disease and cognitive decline DOI Creative Commons
Laurel R. Seemiller, Julio Flores-Cuadra,

Keith R. Griffith

et al.

Neurobiology of Stress, Journal Year: 2024, Volume and Issue: 29, P. 100605 - 100605

Published: Jan. 4, 2024

Alzheimer's Disease and related dementias (ADRD) are an increasing threat to global health initiatives. Efforts prevent the development of ADRD require understanding behaviors that increase decrease risk neurodegeneration cognitive decline, in addition uncovering underlying biological mechanisms behind these effects. Stress exposure alcohol consumption have both been associated with increased for human populations. However, our ability understand causal requires substantial preclinical research. In this review, we summarize existing animal research investigating connections between lifetime stress exposures ADRD.

Language: Английский

Citations

13
Fatores associados ao consumo de álcool por estudantes adolescentes no período pós-pandemia DOI Creative Commons

Eliane Rodrigues de Carvalho Silva,

Jael Maria de Aquino, Angélica de Godoy Torres Lima

et al.

Contribuciones a las Ciencias Sociales, Journal Year: 2024, Volume and Issue: 17(2), P. e2194 - e2194

Published: Feb. 26, 2024

O álcool é a droga mais consumida mundialmente, acarretando um dos maiores problemas de saúde pública, especialmente para os adolescentes devido aos prejuízos causados ao seu desenvolvimento cerebral. Analisar prevalência e fatores associados consumo em uma escola pública capital do nordeste brasileiro no período pós-pandemia. Pesquisa transversal, analítica, quantitativa, realizada com 73 da rede estadual, agosto outubro 2022. Foi aplicado questionário sociodemográfico, o AUDIT (Alcohol Use Disorder Identification Test) CDI (Child Depression Inventory), avaliar sintomas depressivos. Realizou-se testes hipóteses estatísticas, considerando nível significância 5%. 91,5% participantes apontaram baixo risco uso inadequado álcool, 5,5% risco, 2,7% provável dependência nenhum apresentou nocivo. Os foram ser sexo feminino, LGBT, filhos pais solos, ter horas acesso à internet, já experimentado bebida alcoólica e/ou consumi-la habitualmente. Verificou-se importância olhar cuidadoso mulheres, LGBTs, pressão que sociedade pode exercer sobre esse público, bem como necessidade políticas públicas atendam essa população, principalmente nos ambientes próximos família escola.

Citations

12
Liraglutide Reduces Alcohol Consumption, Anxiety, Memory Impairment, and Synapse Loss in Alcohol Dependent Mice DOI
Weizhen Liu, Ziliang Wang, Wang Wang

et al.

Neurochemical Research, Journal Year: 2024, Volume and Issue: 49(4), P. 1061 - 1075

Published: Jan. 24, 2024

Language: Английский

Citations

11
Impact of the COVID-19 pandemic on alcohol consumption in young adults: A systematic review DOI
Lorena Botella-Juan,

Daniela Vargas-Caraballo,

Antonio J. Molina

et al.

Public Health, Journal Year: 2025, Volume and Issue: 240, P. 1 - 11

Published: Jan. 22, 2025

Language: Английский

Citations

1
Relationship between serum homocysteine, folate and vitamin B12 levels and cognitive function in patients with drug-naive obsessive-compulsive disorder DOI Creative Commons
Yang Ding,

Shihao Lu,

Shaoxia Wang

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 25, 2025

The study aimed to investigate the correlation between Homocysteine (HCY), folate and vitamin B12 (VB12) levels cognitive function in patients with drug-naive obsessive-compulsive disorder (OCD).Fifty OCD 50 matched healthy controls recruited were enrolled. Subjects cognitively assessed using MATRICS Consensus Cognitive Battery (MCCB) scales. Serum HCY, floate, collected.There was impairment memory, attention compared control group (P < 0.05). There significant differences HCY SPSS mediated effects model 4 analyses showed that relationship Y-BCOS scores verbal learning ability (median effect value: -0.43, 95% CI [-0.58 ~ -0.28]). Folate also Y-BOCS -0.11,95% CI: [-0.21 ~-0.03]). positively correlated symptom severity ability, speed of information processing, impaired emotion management OCD, may be protective against changes OCD. together affect function.

Language: Английский

Citations

1