Role of Glial Cells in Neuronal Function, Mood Disorders, and Drug Addiction

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(6), P. 558 - 558

Published: May 30, 2024

Mood disorders and substance use disorder (SUD) are of immense medical social concern. Although significant progress on neuronal involvement in mood reward circuitries has been achieved, it is only relatively recently that the role glia these attracted attention. Detailed understanding glial functions devastating diseases could offer novel interventions. Here, following a brief review involved regulation perception, specific contributions neurotrophic factors, neuroinflammation, gut microbiota to highlighted. In this context, cells (e.g., microglia, astroglia, oligodendrocytes, synantocytes) phenotypic manifestation or SUD emphasized. addition, knowledge potential development therapeutics touched upon.

Language: Английский

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Substance-Induced Psychiatric Disorders, Epigenetic and Microbiome Alterations, and Potential for Therapeutic Interventions

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(8), P. 769 - 769

Published: July 30, 2024

Substance use disorders (SUDs) are complex biopsychosocial diseases that cause neurocognitive deficits and neurological impairments by altering the gene expression in reward-related brain areas. Repeated drug gives rise to alterations DNA methylation, histone modifications, of microRNAs several areas may be associated with development psychotic symptoms. The first section this review discusses how substance contributes symptoms via epigenetic alterations. Then, we present more evidence about link between SUDs next presents associations paternal maternal exposure substances brains offspring role diet preventing substance-induced impairments. introduce potential therapeutic agents/approaches such as methyl-rich diets modify for alleviating or depression SUDs. Next, discuss use–gut microbiome interactions contribute through gut microbiome-derived metabolites become new therapeutics normalizing aberrations. Finally, address possible challenges future perspectives patients modulating diets, epigenome, microbiome.

Language: Английский

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Green sanctuaries: residential green and garden space and the natural environment mitigate mental disorders risk of diabetic patients

BMC Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 21, 2025

Abstract Background The co-occurrence of diabetes and mental disorders is an exceedingly common comorbidity with poor prognosis. We aim to investigate the impact green space, garden natural environment on risk among population living diabetes. Methods performed a longitudinal analysis based 39,397 participants from UK Biobank. Residential space modeled land use data Land Cover Map were assigned residential address for each participant. Cox proportional hazards model was used analyze associations between nature exposures Casual mediation quantify indirect effect air pollution. Results During mean follow-up 7.55 years, 4513 incident cases identified, including 2952 depressive 1209 anxiety disorders. Participants at 300 m buffer in second third tertiles had 7% (HR = 0.93, 95%CI: 0.86–0.99) 12% 0.88, 0.82–0.94) lower risks compared those first tertile, respectively. incidence patients will decrease by 13% when exposed tertile buffer. individually prevented 6.65% 10.18% incidents patients. statistically decreased 1000 0.84, 95% CI: 0.78–0.90). Protective effects three against also observed. Air pollution, particularly nitrogen dioxide, oxides, fine particulate matter, significantly contributed disorders, mediating 48.3%, 29.2%, 62.4% associations, Conclusions could mitigate patients, pollution playing vital mediator. This highlights potential local governments enhance sustainability such interventions, grounded public health urban planning, through strategic planning initiatives. Graphical

Language: Английский

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Characterization of the gut microbiota in drug abuse: prediction, prevention, and personalized medicine to benefit affected populations

The EPMA Journal, Journal Year: 2025, Volume and Issue: unknown

Published: March 15, 2025

Language: Английский

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Role of EV-mediated neurodegeneration in substance use disorders

Current Opinion in Physiology, Journal Year: 2025, Volume and Issue: unknown, P. 100826 - 100826

Published: March 1, 2025

Language: Английский

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Efficacy of probiotic supplements in improving the symptoms of psychosis, anxiety, insomnia, and anorexia due to amphetamine and methamphetamine use: a randomized clinical trial

Psychopharmacology, Journal Year: 2024, Volume and Issue: 241(7), P. 1463 - 1476

Published: March 21, 2024

Language: Английский

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The microbial community dynamics of cocaine sensitization in two behaviorally divergent strains of collaborative cross mice

Genes Brain & Behavior, Journal Year: 2023, Volume and Issue: 22(3)

Published: April 27, 2023

Abstract The gut‐brain axis is increasingly recognized as an important pathway involved in cocaine use disorder. Microbial products of the murine gut have been shown to affect striatal gene expression, and depletion microbiome by antibiotic treatment alters cocaine‐induced behavioral sensitization C57BL/6J male mice. Some reports suggest that correlated with drug self‐administration behavior Here, we profile composition naïve its response two collaborative cross (CC) strains. These strains display extremely divergent responses sensitization. A high‐responding strain, CC004/TauUncJ (CC04), has a contains greater amount Lactobacillus than cocaine‐nonresponsive strain CC041/TauUncJ (CC41). CC41 characterized abundance Eisenbergella , Robinsonella Ruminococcus. In cocaine, CC04 increased Barnsiella population, while displays no significant changes. PICRUSt functional analysis potential shows number modules altered after exposure specifically those encoding for tryptophan synthesis, glutamine metabolism, menaquinone synthesis (vitamin K2). Depletion revealed cocaine‐sensitization following antibiotics female Depleting males infusions during intravenous dose–response curve. Together these data genetic differences cocaine‐related behaviors may involve microbiome.

Language: Английский

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Genetically predicted fatty liver disease and risk of psychiatric disorders: A mendelian randomization study

World Journal of Clinical Cases, Journal Year: 2024, Volume and Issue: 12(14), P. 2359 - 2369

Published: April 29, 2024

BACKGROUND Non-alcoholic fatty liver disease (NAFLD) and alcohol-related (ArLD) constitute the primary forms of chronic disease, their incidence is progressively increasing with changes in lifestyle habits. Earlier studies have documented a correlation between occurrence development prevalent mental disorders liver. AIM To investigate disorders, thus necessitating implementation mendelian randomization (MR) study to elucidate this association. METHODS Data on NAFLD ArLD were retrieved from genome-wide association catalog, while information including Alzheimer's schizophrenia, anxiety disorder, attention deficit hyperactivity disorder (ADHD), bipolar major depressive multiple personality obsessive-compulsive (OCD), post-traumatic stress (PTSD), schizophrenia was acquired psychiatric genomics consortium. A two-sample MR method applied mediators significant associations. RESULTS After excluding weak instrumental variables, causal relationship identified some disorders. Specifically, findings indicated that associated significantly elevated risk developing ADHD (OR: 5.81, 95%CI: 5.59-6.03, P < 0.01), 5.73, 5.42-6.05, = 0.03), OCD 6.42, 5.60-7.36, PTSD 5.66, 5.33-6.01, 0.01). Meanwhile, increased 55.08, 3.59-845.51, 61.50, 6.69-565.45, 52.09, 4.24-639.32, CONCLUSION Associations found genetic predisposition an broad range namely OCD, PTSD, highlighting significance preventive measures against patients disease.

Language: Английский

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Gut microbial diversity and functional characterization in people with alcohol use disorder: A case-control study

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(6), P. e0302195 - e0302195

Published: June 12, 2024

Individuals with Alcohol Use Disorder (AUD) typically have comorbid chronic health conditions, including anxiety and depression disorders, increased sleep disruption, poor nutrition status, along gut microbial dysbiosis. To better understand the effects of dysbiosis previously shown in individuals AUD, microbiome metabolome were investigated between three cohorts. Two groups AUD included treatment-seeking newly abstinent for at least six weeks (AB: N = 10) non-treatment-seeking currently drinking (CD: 9) individuals. The third group was age, gender, BMI-matched healthy controls (HC: 12). Deep phenotyping during two outpatient National Institutes Health Clinical Center visits performed, clinical, psychological, medical, metabolic, dietary, experimental assessments. Alpha beta diversity differential taxa metabolite abundance examined across groups. Metabolites derived from lipid super-pathway identified to be more abundant AB compared CD HC appeared most clinically different respect their metabolome. These findings highlight potential long-term alcohol use even short-term abstinence.

Language: Английский

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Role of Glial Cells in Depression and Drug Addiction

Published: May 3, 2024

Major depressive disorder (MDD) and substance use (SUD) are of immense medical social concerns. Although significant progress on neuronal involvement in mood reward circuitries has been achieved, only relatively recently the role glia these disorders have attracted attention. Detail understanding glial function devastating diseases could offer novel interventions. Here, following a brief review involved regulation perception, specific contribution neurotrophic factors, neuroinflammation gut microbiota to highlighted. In this context, cells (e.g., microglia, astroglia, oligodendrocytes synantocytes) phenotypic manifestation MDD or SUD emphasized. addition, potential knowledge developing therapeutics is touched upon.

Language: Английский

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