Endogenous opiates and behavior: 2023
Peptides,
Journal Year:
2024,
Volume and Issue:
179, P. 171268 - 171268
Published: June 28, 2024
Language: Английский
Enantiomeric contributions to methamphetamine's bidirectional effects on basal and fentanyl-depressed respiration in mice
Pharmacology Biochemistry and Behavior,
Journal Year:
2024,
Volume and Issue:
238, P. 173735 - 173735
Published: Feb. 17, 2024
Language: Английский
Monoamine receptors targeted by methamphetamine differentially modulate basal and fentanyl-depressed respiration in mice
Pharmacology Biochemistry and Behavior,
Journal Year:
2025,
Volume and Issue:
unknown, P. 174004 - 174004
Published: March 1, 2025
Language: Английский
Progress in Methylxanthine Biosynthesis: Insights into Pathways and Engineering Strategies
Tongtong Jiang,
No information about this author
Shangci Zuo,
No information about this author
Chang Yu Liu
No information about this author
et al.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(4), P. 1510 - 1510
Published: Feb. 11, 2025
Methylxanthines
are
ubiquitous
purine
alkaloids
in
nature
and
have
rich
biological
activities
functions.
Today,
the
demand
for
methylxanthine
is
increasing
but
its
production
low.
This
issue
prevents
widespread
use
many
industrial
fields,
such
as
pharmaceuticals,
food
manufacturing,
chemical
engineering.
To
address
these
issues,
this
review
provides
a
comprehensive
systematic
exploration
of
methylxanthines,
delving
into
their
structures,
detailed
biosynthetic
pathways,
latest
research
trends.
These
findings
serve
valuable
references
researchers,
fostering
advancements
optimization
synthesis
processes
methylxanthines
derivatives
promoting
application
across
diverse
medicine,
food,
By
bridging
fundamental
practical
applications,
work
aims
to
advance
understanding
compounds,
enhance
efficiency,
contribute
healthcare
technological
progress.
Language: Английский
Fentanyl Overdose Causes Prolonged Cardiopulmonary Dysregulation in Male SKH1 Mice
Mackenzie Newman,
No information about this author
Heather Connery,
No information about this author
Swapna Kannan
No information about this author
et al.
Pharmaceuticals,
Journal Year:
2024,
Volume and Issue:
17(7), P. 941 - 941
Published: July 14, 2024
Fentanyl
overdose
is
a
survivable
condition
that
commonly
resolves
without
chronic
overt
changes
in
phenotype.
While
the
acute
physiological
effects
of
fentanyl
overdose,
such
as
opioid-induced
respiratory
depression
(OIRD)
and
Wooden
Chest
Syndrome,
represent
immediate
risks
lethality,
little
known
about
longer-term
systemic
or
organ-level
impacts
for
survivors.
In
this
study,
we
investigated
single,
bolus
on
components
cardiopulmonary
system
up
to
one
week
post.
SKH1
mice
were
administered
subcutaneous
at
highest
non-lethal
dose
(62
mg/kg),
LD10
(110
LD50
(135
before
euthanasia
40
min,
6
h,
24
7
d
post-exposure.
The
cerebral
cortex,
heart,
lungs,
plasma
assayed
using
an
immune
monitoring
48-plex
panel.
results
showed
significantly
dysregulated
cytokine,
chemokine,
growth
factor
concentrations
compared
time-matched
controls,
principally
hearts,
then
lungs
lesser
extent,
length
with
cortex
largely
unaffected.
Major
significant
analytes
contributing
variance
included
eotaxin-1,
IL-33,
betacellulin,
which
generally
downregulated
across
time.
study
suggest
toxicity
may
persist
from
single
have
wide
implications
endurance
expanding
population
Language: Английский
Enantiomeric and Monoaminergic Contributions to Methamphetamine's Bidirectional Effects on Fentanyl-Depressed Respiration in Mice
Authorea (Authorea),
Journal Year:
2023,
Volume and Issue:
unknown
Published: Oct. 30, 2023
Rationale:
Fentanyl
remains
the
primary
cause
of
fatal
overdoses,
and
its
co-use
with
methamphetamine
(METH)
is
a
growing
concern.
The
optical
isomers
METH,
dextromethamphetamine
(d-METH)
levomethamphetamine
(l-METH),
differ
substantially
in
dose
expression
thus
may
differentially
contribute
to
racemate’s
bidirectional
effects.
Furthermore,
it
unknown
which
METH’s
monoamine
(MA)
receptor
mechanisms
mediate
these
respiratory
Thus,
systematic
evaluation
selective
agents
identify
treatment
targets
for
OIRD.
Methods:
two
d-METH
l-METH,
were
tested
adult
male
mice
determine
their
effects
on
basal
fentanyl-depressed
minute
volume
(MVb;
i.e.,
frequency
x
tidal
volum)
using
whole-body
plethysmography.
Next,
six
agonists
at
MA
receptors
involved
activity
[phenylephrine
(PNE;
α1),
clonidine
(CLON;
α2),
SKF-82958
(SKF;
D1),
quinpirole
(QPR;
D2),
8-OH-DPAT
(8-OH;
5HT1A),
DOI
(5HT2)]
singly
MVb,
then
combination
fentanyl.
Results:
elevated
MVb
l-METH
decreased
MVb.
Under
conditions,
racemic
METH
recreated
by
while
significantly
exacerbated
OIRD
1.0
3.0
mg/kg.
was
dose-dependently
increased
PNE
SKF
CLON
QPR.
Neither
8-OH
nor
altered
transiently
more
persistently
it,
Conclusions:
modulation
observed
racemate
activation
respiration
Language: Английский