Life,
Journal Year:
2023,
Volume and Issue:
13(9), P. 1797 - 1797
Published: Aug. 23, 2023
The
small
compound
[5-(3,4-dichlorophenyl)
furan-2-yl]-piperidine-1-ylmethanethione
(DFPM)
inhibits
ABA
responses
by
activating
effector-triggered
immune
signal
transduction
in
Arabidopsis.
In
addition
to
the
known
function
of
DFPM
as
an
antagonist
signaling,
causes
accession-specific
root
growth
arrest
Arabidopsis
Columbia-0
via
TIR-NLR
protein
VICTR
(VARIATION
IN
COMPOUND
TRIGGERED
ROOT
response)
EDS1/PAD4/RAR1/SGT1B-dependent
manner.
Although
could
control
specific
steps
various
cellular
responses,
functional
residues
for
activity
or
existence
a
stronger
version
modification
have
not
been
characterized
thoroughly.
This
study
analyzed
twenty-two
derivatives
during
arrest,
inhibition
and
induction
biotic
determine
critical
that
confer
DFPM.
Furthermore,
this
identified
two
more
accessions
generate
significant
response
dependent
on
multiple
amino
acid
polymorphisms
coding
region
VICTR.
isolation
novel
compounds,
such
DFPM-5,
compound-induced
will
help
detailed
regulatory
mechanism
how
regulates
abiotic
stress
signaling
interactions.
Journal of Experimental Botany,
Journal Year:
2024,
Volume and Issue:
75(22), P. 6918 - 6938
Published: Sept. 9, 2024
Abstract
In
reaction
to
a
stimulus,
signaling
molecules
are
made,
generate
response,
and
then
degraded.
Nucleotides
classically
associated
with
central
metabolism
nucleic
acid
biosynthesis,
but
there
number
of
nucleotides
nucleotide
derivatives
in
plants
which
this
simple
definition
molecule
applies
whole
or
at
least
part.
These
include
cytokinins
chloroplast
guanosine
tetraposphate
(ppGpp),
as
well
extracellular
canonical
such
ATP
(eATP)
NAD+
(eNAD+).
addition,
is
series
compounds
derived
from
ADP
ribose
(ADPR),
ATP–ADPR
dinucleotides
their
hydrolysis
products
(e.g.
pRib-AMP)
together
different
variants
cyclic
ADPR
(cADPR,
2´-cADPR,
3´-cADPR),
also
3´,5´-cAMP
2´,3´-cyclic
nucleoside
monophosphates.
Interestingly,
some
these
have
recently
been
shown
play
role
pathogen
defense.
review,
we
highlight
exciting
new
developments.
We
review
that
considered
candidates
for
molecules,
example
purine
deoxynucleosides,
discuss
more
controversial
cases.
Journal of Experimental Botany,
Journal Year:
2023,
Volume and Issue:
74(19), P. 6052 - 6068
Published: July 13, 2023
Plants
use
different
receptors
to
detect
potential
pathogens:
membrane-anchored
pattern
recognition
(PRRs)
activated
upon
perception
of
pathogen-associated
molecular
patterns
(PAMPs)
that
elicit
pattern-triggered
immunity
(PTI);
and
intracellular
nucleotide-binding
leucine-rich
repeat
proteins
(NLRs)
by
detection
pathogen-derived
effectors,
activating
effector-triggered
(ETI).
The
interconnections
between
PTI
ETI
responses
have
been
increasingly
reported.
Elevated
NLR
levels
may
cause
autoimmunity,
with
symptoms
ranging
from
fitness
cost
developmental
arrest,
sometimes
combined
run-away
cell
death,
making
accurate
control
dosage
key
for
plant
survival.
Small
RNA-mediated
gene
regulation
has
emerged
as
a
major
mechanism
dosage.
Twenty-two
nucleotide
miRNAs
the
unique
ability
trigger
secondary
siRNA
production
target
transcripts
are
particularly
prevalent
in
regulation.
They
enhance
repression
primary
target,
but
also
bring
about
NLRs
only
complementary
siRNAs.
We
summarize
current
knowledge
on
siRNAs
expression
an
emphasis
22
nt
propose
miRNA
provides
additional
links
defense
pathways
increase
responsiveness
against
broad
spectrum
pathogens
efficient
deployment
defenses.
Molecular Plant,
Journal Year:
2023,
Volume and Issue:
17(1), P. 92 - 111
Published: Dec. 15, 2023
Angiosperms
represent
most
plants
that
humans
cultivate,
grow,
and
eat.
However,
angiosperms
are
only
one
of
five
major
land
plant
lineages.
As
a
whole
lineage,
also
include
algal
groups.
All
these
clades
tremendous
genetic
diversity
can
be
investigated
to
reveal
the
evolutionary
history
any
given
mechanism.
In
this
review,
we
describe
current
model
immune
system,
discuss
its
evolution
based
on
recent
literature,
propose
future
directions
for
field.
angiosperms,
plant-microbe
interactions
have
been
intensively
studied,
revealing
essential
cell
surface
intracellular
receptors,
as
well
metabolic
hormonal
defense
pathways.
Exploring
at
genomic
functional
levels
demonstrates
conservation
pathways
across
plants,
some
which
beyond
plants.
On
basis
conserved
mechanisms,
lineage-specific
variations
occurred,
leading
diversified
reservoirs
mechanisms.
rare
cases,
has
harnessed
successfully
transferred
other
species
by
integration
wild
receptors
or
engineering
novel
forms
improved
resistance
pathogens.
We
exploring
further
mechanisms
in
lineage
will
completely
sources
deployed
crops.
Journal of Experimental Botany,
Journal Year:
2023,
Volume and Issue:
75(5), P. 1530 - 1546
Published: Nov. 17, 2023
Arabidopsis
PHYTOALEXIN
DEFICIENT
4
(PAD4)
has
an
essential
role
in
pathogen
resistance
as
a
heterodimer
with
ENHANCED
DISEASE
SUSCEPTIBILITY
1
(EDS1).
Here
we
investigated
additional
PAD4
which
it
associates
and
promotes
the
maturation
of
immune-related
cysteine
protease
RESPONSIVE
TO
DEHYDRATION
19
(RD19).
We
found
that
RD19
its
paralog
RD19c
promoted
EDS1-
PAD4-mediated
effector-triggered
immunity
to
avirulent
Pseudomonas
syringae
strain,
DC3000,
expressing
effector
AvrRps4
basal
against
fungal
Golovinomyces
cichoracearum.
Overexpression
RD19,
but
not
protease-inactive
catalytic
mutants,
transgenic
lines
caused
PAD4-dependent
autoimmunity
enhanced
resistance.
In
these
lines,
pro-form
required
residues,
suggesting
undergoes
auto-processing.
transient
assays,
interacted
preferentially
pro-protease
nuclear
accumulation
leaf
cells.
Our
results
lead
us
propose
model
for
PAD4-stimulated
defense
potentiation.
processed
then
stimulates
EDS1-PAD4
dimer
activity
confer
This
study
highlights
potentially
important
functions
eventually
converge
on
canonical
signaling
plant
immunity.
Annual Review of Plant Biology,
Journal Year:
2024,
Volume and Issue:
75(1), P. 67 - 93
Published: March 1, 2024
B
vitamins
are
a
source
of
coenzymes
for
vast
array
enzyme
reactions,
particularly
those
metabolism.
As
metabolism
is
the
basis
decisions
that
drive
maintenance,
growth,
and
development,
vitamin–derived
key
components
facilitate
these
processes.
For
over
century,
we
have
known
about
essential
compounds
elucidated
their
pathways
biosynthesis,
repair,
salvage,
degradation
in
numerous
organisms.
Only
now
beginning
to
understand
importance
regulatory
processes,
which
becoming
an
important
topic
plants.
Here,
I
highlight
discuss
emerging
evidence
on
how
integrated
into
vital
from
energy
generation
nutrition
gene
expression,
thereby
contribute
coordination
growth
developmental
programs,
concern
maintenance
stable
state,
foundational
tenet
plant
homeostasis.
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: April 8, 2024
Withdrawal
Statement
The
authors
have
withdrawn
this
manuscript
owing
to
finding
inconsistencies
in
genotyping
of
kitaake
rice
eds1
pad4
double
mutant
lines
and
establishing
that
combined
loss
EDS1
PAD4
does
not
underlie
the
stunted
‘autoimmune-like’
phenotype
reported
preprint.
Therefore,
do
wish
work
be
cited
as
reference
for
project.
If
you
any
questions,
please
contact
corresponding
authors:
Jane
Parker,
Thomas
Kroj
Haitao
Cui
(co-corresponding)
Life,
Journal Year:
2023,
Volume and Issue:
13(9), P. 1797 - 1797
Published: Aug. 23, 2023
The
small
compound
[5-(3,4-dichlorophenyl)
furan-2-yl]-piperidine-1-ylmethanethione
(DFPM)
inhibits
ABA
responses
by
activating
effector-triggered
immune
signal
transduction
in
Arabidopsis.
In
addition
to
the
known
function
of
DFPM
as
an
antagonist
signaling,
causes
accession-specific
root
growth
arrest
Arabidopsis
Columbia-0
via
TIR-NLR
protein
VICTR
(VARIATION
IN
COMPOUND
TRIGGERED
ROOT
response)
EDS1/PAD4/RAR1/SGT1B-dependent
manner.
Although
could
control
specific
steps
various
cellular
responses,
functional
residues
for
activity
or
existence
a
stronger
version
modification
have
not
been
characterized
thoroughly.
This
study
analyzed
twenty-two
derivatives
during
arrest,
inhibition
and
induction
biotic
determine
critical
that
confer
DFPM.
Furthermore,
this
identified
two
more
accessions
generate
significant
response
dependent
on
multiple
amino
acid
polymorphisms
coding
region
VICTR.
isolation
novel
compounds,
such
DFPM-5,
compound-induced
will
help
detailed
regulatory
mechanism
how
regulates
abiotic
stress
signaling
interactions.
