Viperin immunity evolved across the tree of life through serial innovations on a conserved scaffold

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Sept. 13, 2023

Abstract Evolutionary arms races between cells and viruses drive the rapid diversification of antiviral genes in diverse life forms. Recent discoveries have revealed existence shared immune prokaryotes eukaryotes, showing molecular mechanistic similarities their response to viruses. However, underlying evolutionary dynamics that explain conservation adaptation these remain mostly unexplored. Here, we show viperins constitute a highly conserved family across uncover mechanisms by which they diversified eukaryotes. Our findings indicate are enriched Asgard archaea widely distributed all major eukaryotic clades, suggesting presence Last Eukaryotic Common Ancestor (LECA). We maintain function producing nucleotide analogs. demonstrate through serial innovations on viperin gene, such as emergence selection substrate specificity towards pyrimidine nucleotides, partnerships with maintained genetic linkage, notably kinases. These unveil biochemical genomic transitions study paves way for understanding immunity domains life.

Language: Английский

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A cluster of putative resistance genes is associated with a dominant resistance to sunflower broomrape

Theoretical and Applied Genetics, Journal Year: 2024, Volume and Issue: 137(5)

Published: April 13, 2024

Language: Английский

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Identifying nucleotide-binding leucine-rich repeat receptor and pathogen effector pairing using transfer-learning and bilinear attention network

Bioinformatics, Journal Year: 2024, Volume and Issue: 40(10)

Published: Sept. 27, 2024

Nucleotide-binding leucine-rich repeat (NLR) family is a class of immune receptors capable detecting and defending against pathogen invasion. They have been widely used in crop breeding. Notably, the correspondence between NLRs effectors (CNE) determines applicability effectiveness NLRs. Unfortunately, CNE data very scarce. In fact, we've found substantial 91 291 confirmed via wet experiments bioinformatics methods but only 387 CNEs are recognized, which greatly restricts potential application

Language: Английский

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Assessment of the Predictive Ability of the Neutrophil-to-Lymphocyte Ratio in Patients with In-Stent Restenosis after COVID-19

Diagnostics, Journal Year: 2024, Volume and Issue: 14(20), P. 2262 - 2262

Published: Oct. 11, 2024

Background: The neutrophil-to-lymphocyte ratio (NLR) is an independent predictor of the severity coronary heart disease and COVID-19. This study aims to assess predictive ability NLR in patients with in-stent restenosis after Materials Methods: a cross-sectional included 931 who underwent repeated myocardial revascularization between May 2020 2023. 420 main group had restenosis, which 162 COVID-19 previously. control 511 without stent (107 previously). All reported events were verified by hospital electronic records from Complex Medical Information System. Results: mean values 2.51 2.68 groups, respectively. A statistically significant positive relationship both groups was found troponin, D-dimer, C-reactive protein, creatinine, ALT, AST. infarction (MI) (p = 0.004; p < 0.001, respectively) negative ejection fraction 0.001; 0.036, respectively). An evaluation clinical laboratory predictors recurrent shows high degree utility this model. area under ROC curve for AUC 0.664 95% CI 0.627 0.700 0.001). Conclusions: one factors predicting development adverse outcomes revascularized myocardium

Language: Английский

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Observing root growth and signalling responses to stress gradients and pathogens using the bi-directional dual-flow RootChip

Lab on a Chip, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Plants respond to environmental stressors with adaptive changes in growth and development. Central these responses is the role of calcium (Ca

Language: Английский

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