Advanced Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 18, 2024
Unlike
animals,
plants
are
unable
to
move
and
lack
specialized
immune
cells
circulating
antibodies.
As
a
result,
they
always
threatened
by
large
number
of
microbial
pathogens
harmful
pests
that
can
significantly
reduce
crop
yield
worldwide.
Therefore,
the
development
new
strategies
control
them
is
essential
mitigate
increasing
risk
crops
lost
plant
diseases.
Recent
developments
in
genetic
engineering,
including
efficient
gene
manipulation
transformation
methods,
editing
synthetic
biology,
coupled
with
understanding
pathogenicity
immunity,
both
at
molecular
genomic
levels,
have
enhanced
capabilities
develop
disease
resistance
plants.
This
review
comprehensively
explains
fundamental
mechanisms
underlying
tug-of-war
between
hosts,
provides
detailed
overview
different
for
developing
Additionally,
it
summary
potential
genes
be
employed
breeding
key
combat
wide
range
pests,
fungi,
oomycetes,
bacteria,
viruses,
nematodes,
insects.
Furthermore,
this
addresses
limitations
associated
these
their
possible
solutions.
Finally,
discusses
future
perspectives
producing
durable
broad-spectrum
resistance.
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: June 16, 2024
ABSTRACT
Parasites
can
counteract
host
immunity
by
suppressing
nucleotide
binding
and
leucine-rich
repeat
(NLR)
proteins
that
function
as
immune
receptors.
We
previously
showed
a
cyst
nematode
virulence
effector
SPRYSEC15
(SS15)
binds
inhibits
oligomerisation
of
helper
NLR
in
the
expanded
NRC1/2/3
clade
preventing
intramolecular
rearrangements
required
for
NRC
into
an
activated
resistosome.
Here
we
examined
degree
to
which
from
multiple
Solanaceae
species
are
sensitive
suppression
SS15
tested
hypotheses
about
adaptive
evolution
interface
between
inhibitor
proteins.
Whereas
all
orthologs
NRC2
were
inhibited
SS15,
some
natural
variants
NRC1
NRC3
insensitive
suppression.
Ancestral
sequence
reconstruction
combined
with
functional
assays
revealed
transitioned
ancestral
suppressed
form
one
over
19
million
years
ago.
Our
analyses
evolutionary
trajectory
coevolution
parasite
its
receptor
target,
identifying
key
transitions
NLRs
this
inhibition.
This
work
reveals
distinct
type
gene-for-gene
interaction
or
pathogen
immunosuppressors
receptors
contrasts
AVR
effectors
The Crop Journal,
Journal Year:
2023,
Volume and Issue:
12(1), P. 28 - 44
Published: Dec. 20, 2023
To
fight
against
invasion
by
pathogens,
plants
have
evolved
an
elaborate
innate
immune
system,
of
which
the
nucleotide-binding
domain
leucine-rich
repeat-containing
receptor
(NLR)
acts
as
sensor
and
executor.
Potyviruses,
comprising
one
largest
genera
plant
viruses,
cause
severe
crop
yield
losses
worldwide.
Inherited
resistance
to
potyviruses
can
be
used
in
breeding
transgenesis
control
disease
development.
This
review
summarizes
achievements
mapping
cloning
NLR
genes
conferring
dominant
potyvirus
families
Fabaceae,
Solanaceae,
Brassicaceae,
Cucurbitaceae.
It
compares
mechanisms
potyviral
protein
recognition
downstream
signaling
employed
NLRs
discusses
strategies
for
exploiting
better
diseases
caused
potyviruses.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 18, 2024
Unlike
animals,
plants
are
unable
to
move
and
lack
specialized
immune
cells
circulating
antibodies.
As
a
result,
they
always
threatened
by
large
number
of
microbial
pathogens
harmful
pests
that
can
significantly
reduce
crop
yield
worldwide.
Therefore,
the
development
new
strategies
control
them
is
essential
mitigate
increasing
risk
crops
lost
plant
diseases.
Recent
developments
in
genetic
engineering,
including
efficient
gene
manipulation
transformation
methods,
editing
synthetic
biology,
coupled
with
understanding
pathogenicity
immunity,
both
at
molecular
genomic
levels,
have
enhanced
capabilities
develop
disease
resistance
plants.
This
review
comprehensively
explains
fundamental
mechanisms
underlying
tug-of-war
between
hosts,
provides
detailed
overview
different
for
developing
Additionally,
it
summary
potential
genes
be
employed
breeding
key
combat
wide
range
pests,
fungi,
oomycetes,
bacteria,
viruses,
nematodes,
insects.
Furthermore,
this
addresses
limitations
associated
these
their
possible
solutions.
Finally,
discusses
future
perspectives
producing
durable
broad-spectrum
resistance.
