The
dominant
paradigm
in
biomedicine
focuses
on
the
genetically-specified
components
of
cells,
and
their
biochemical
dynamics.
This
perspective
emphasizes
bottom-up
emergence
complexity,
which
constrains
interventional
approaches
to
micromanaging
living
hardware.
Here,
I
explore
implications
for
applied
life
sciences
a
complementary
emerging
field:
diverse
intelligence,
studies
capacity
wide
range
systems
reach
specific
goals
various
problem
spaces.
Using
tools
from
behavioral
science
multiscale
neuroscience,
it
is
possible
address
development,
regenerative
repair,
cancer
as
behaviors
collective
intelligence
cells
navigates
space
morphologies
transcriptional
physiological
states.
view
competencies
material
–
molecular
organismal
scales
that
can
be
targeted
by
interventions.
Top-down
take
advantage
memories
homeodynamic
goal-seeking
behavior,
offering
same
massive
advantages
bioengineering
emphasis
reprogrammable
hardware
has
had
information
technologies.
bioelectric
networks
bind
individual
toward
large-scale
anatomical
are
an
especially
tractable
interface
organ-level
plasticity.
suggests
research
program
understand
tame
software
understanding
many
examples
basal
cognition
operate
throughout
bodies.
Tools
now
place
unify
organicist
mechanist
perspectives
much-improved
therapeutic
landscape.
Entropy,
Journal Year:
2024,
Volume and Issue:
26(6), P. 481 - 481
Published: May 31, 2024
Many
studies
on
memory
emphasize
the
material
substrate
and
mechanisms
by
which
data
can
be
stored
reliably
read
out.
Here,
I
focus
complementary
aspects:
need
for
agents
to
dynamically
reinterpret
modify
memories
suit
their
ever-changing
selves
environment.
Using
examples
from
developmental
biology,
evolution,
synthetic
bioengineering,
in
addition
neuroscience,
propose
that
a
perspective
as
preserving
salience,
not
fidelity,
is
applicable
many
phenomena
scales
cells
societies.
Continuous
commitment
creative,
adaptive
confabulation,
molecular
behavioral
levels,
answer
persistence
paradox
it
applies
individuals
whole
lineages.
also
speculate
substrate-independent,
processual
view
of
life
mind
suggests
memories,
patterns
excitable
medium
cognitive
systems,
could
seen
active
sense-making
process.
explore
diverse
set
embodied
perspectives—nested
who
interpret
each
other’s
own
past
messages
actions
best
they
(polycomputation).
This
synthesis
unifying
symmetries
across
disciplines,
relevance
research
programs
Diverse
Intelligence
engineering
novel
minds.
Entropy,
Journal Year:
2025,
Volume and Issue:
27(3), P. 280 - 280
Published: March 7, 2025
The
known
laws
of
nature
in
the
physical
sciences
are
well
expressed
language
mathematics,
a
fact
that
caused
Eugene
Wigner
to
wonder
at
“unreasonable
effectiveness”
mathematical
concepts
explain
phenomena.
biological
sciences,
contrast,
have
resisted
formulation
precise
model
complexity
living
world.
limits
mathematics
biology
discussed
as
stemming
from
impossibility
constructing
deterministic
“Laplacian”
and
failure
set
theory
capture
creative
evolutionary
processes
biosphere.
Indeed,
transcends
computation.
This
leads
necessity
finding
new
formalisms
describe
reality,
with
or
without
strictly
approaches.
In
former
case,
expressions
do
not
demand
numerical
equivalence
(equations)
provide
useful
information
exact
predictions.
Examples
approximations
equal
signs
given.
ineffectiveness
is
an
invitation
expand
science
see
creativity
formalism.
Biosystems,
Journal Year:
2023,
Volume and Issue:
235, P. 105109 - 105109
Published: Dec. 27, 2023
A
range
of
studies
published
in
the
last
few
decades
promotes
cognitive
aspects
life:
all
organisms,
from
bacteria
to
mammals,
are
capable
sensing/perception,
decision-making,
problem-solving,
learning,
and
other
functions,
including
sentience
consciousness.
In
this
paper
I
present
a
scientific
philosophical
synthesis
these
studies,
leading
an
integrated
view
biology.
This
is
expressed
through
four
principles
applicable
living
systems:
(1)
consciousness,
(2)
autopoiesis,
(3)
free
energy
principle
relational
biology,
(4)
repertoire.
The
circular,
they
reinforce
themselves.
circularity
not
rigid,
meaning
that
hierarchical
heterarchical
shifts
widespread
biosphere.
above
emerged
at
dawn
life,
with
first
cells,
archaea.
All
biogenic
forms
functions
since
then
can
be
traced
cells
–
indivisible
units
biological
agency.
Following
principles,
developed
concept
biocivilisations
explain
various
social
intelligence
different
kingdoms
life.
term
biociviloisations
draws
on
human
interpretation
civilisation,
which
searches
for
non-human
equivalents
communication,
engineering,
science,
medicine,
art,
agriculture,
life
by
applying
Potential
avenues
testing
highlighted.
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Feb. 21, 2024
Abstract
How
do
multiple
active
components
at
one
level
of
organisation
create
agential
wholes
higher
levels
organisation?
For
example,
in
organismic
development,
how
does
the
multi-scale
autonomy
organism
arise
from
interactions
molecules,
cells
and
tissues
that
an
contains?
And,
major
evolutionary
transitions,
a
multicellular
organism,
for
as
unit
selective
interests
its
unicellular
ancestors?
We
utilise
computational
models
way
to
think
about
this
general
question.
take
deliberately
minimalistic
notion
agent:
competency
two
possible
actions
minimise
stress.
Helping
ourselves
behaviour
microscale,
we
focus
on
conditions
where
same
type
agency
appears
spontaneously
organisation.
find
simple
process
positive
feedback
timing
individual
responses,
loosely
analogous
natural
phase
synchronisation
weakly
coupled
oscillators,
causes
such
transition
behaviour.
The
emergent
collectives
become,
quite
suddenly,
able
respond
their
external
stresses
(minimal)
sense
original
microscale
units.
This
effects
dramatic
rescaling
system
behaviour,
quantifiable
increase
problem-solving
competency,
serving
model
higher-level
emerges
pool
lower-level
agents
or
matter.
discuss
dynamical
‘waking-up’
collectives,
through
alignment
internal
dynamics,
might
relate
reproductive/cell-cycle
transitions
development.
