Abstract
At
present,
more
and
people
are
suffering
from
various
diseases
it
is
particularly
important
to
find
a
suitable
biological
model
evaluate
the
prevention
treatment
effects
of
drugs
active
ingredients
on
diseases.
In
all
models,
Caenorhabditis
elegans
kind
organism
that
easy
observe
cultivate,
has
clear
genetic
background
high
degree
signal
pathway
conservation
with
humans.
A
variety
such
as
polyphenols,
polysaccharides,
polypeptides,
vitamins
exist
natural
products,
which
extremely
physiological
functions
medicinal
values.
It
highly
reliable
trophic
functional
properties
products
in
C.
.
The
antiaging,
anti‐oxidation,
regulating
lipid
metabolism,
preventing
treating
Alzheimer's
disease
were
clarified
this
review.
same
time,
its
possible
pathways
summarized.
literature
revealed
had
great
effect
nutrition
functionality
Finally,
shortcomings
field
suggestions
for
further
improvement
have
been
emphasized.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
25(1), P. 158 - 158
Published: Dec. 21, 2023
During
the
postnatal
stages,
skeletal
muscle
development
undergoes
a
series
of
meticulously
regulated
alterations
in
gene
expression.
However,
limited
studies
have
employed
chromatin
accessibility
to
unravel
underlying
molecular
mechanisms
governing
yak
species.
Therefore,
we
conducted
an
analysis
both
expression
levels
and
comprehensively
characterize
dynamic
genome-wide
during
growth
Tianzhu
white
yak,
thereby
elucidating
features
accessible
regions
throughout
this
process.
Initially,
compared
differences
between
two
groups
observed
that
calves
exhibited
higher
adult
cattle,
particularly
within
±2
kb
transcription
start
site
(TSS).
In
order
investigate
correlation
variations
levels,
combination
ATAC-seq
RNA-seq
techniques,
leading
identification
18
central
transcriptional
factors
(TFs)
110
key
genes
with
significant
effects.
Through
further
analysis,
successfully
identified
several
TFs,
including
Sp1,
YY1,
MyoG,
MEF2A
MEF2C,
as
well
number
candidate
(ANKRD2,
ANKRD1,
BTG2
LMOD3)
which
may
be
closely
associated
development.
Moreover,
constructed
interactive
network
program
encompassing
hub
TFs
related
This
innovative
approach
provided
valuable
insights
into
mechanism
stages
yaks
while
also
establishing
solid
theoretical
foundation
for
future
research
on
Abstract
At
present,
more
and
people
are
suffering
from
various
diseases
it
is
particularly
important
to
find
a
suitable
biological
model
evaluate
the
prevention
treatment
effects
of
drugs
active
ingredients
on
diseases.
In
all
models,
Caenorhabditis
elegans
kind
organism
that
easy
observe
cultivate,
has
clear
genetic
background
high
degree
signal
pathway
conservation
with
humans.
A
variety
such
as
polyphenols,
polysaccharides,
polypeptides,
vitamins
exist
natural
products,
which
extremely
physiological
functions
medicinal
values.
It
highly
reliable
trophic
functional
properties
products
in
C.
.
The
antiaging,
anti‐oxidation,
regulating
lipid
metabolism,
preventing
treating
Alzheimer's
disease
were
clarified
this
review.
same
time,
its
possible
pathways
summarized.
literature
revealed
had
great
effect
nutrition
functionality
Finally,
shortcomings
field
suggestions
for
further
improvement
have
been
emphasized.
