Quercetin-loaded mesoporous nano-delivery system remodels osteoimmune microenvironment to regenerate alveolar bone in periodontitis via the miR-21a-5p/PDCD4/NF-κB pathway

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: March 6, 2024

Abstract Background Impaired osteo-/angiogenesis, excessive inflammation, and imbalance of the osteoimmune homeostasis are involved in pathogenesis alveolar bone defect caused by periodontitis. Unfortunately, there is still a lack ideal therapeutic strategies for periodontitis that can regenerate while remodeling microenvironment. Quercetin, as monomeric flavonoid, has multiple pharmacological activities, such pro-regenerative, anti-inflammatory, immunomodulatory effects. Despite its vast spectrum quercetin’s clinical application limited due to poor water solubility low bioavailability. Results In this study, we fabricated quercetin-loaded mesoporous bioactive glass (Quercetin/MBG) nano-delivery system with function continuously releasing quercetin, which could better promote regeneration regulate immune microenvironment compared pure MBG treatment. particular, effectively decreased injection frequency quercetin yielding favorable results. view above excellent effects achieved sustained release further investigated mechanisms. Our findings indicated under microenvironment, intervention restore osteo-/angiogenic capacity periodontal ligament stem cells (PDLSCs), induce regulation macrophages exert an osteoimmunomodulatory effect. Furthermore, also found via be partially blocked overexpression key microRNA——miR-21a-5p, worked through inhibiting expression PDCD4 activating NF-κB signaling pathway. Conclusion summary, our study shows potential approach reconstructing defects it offers new perspective treating miR-21a-5p thereby creating Graphical

Language: Английский

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Protective effect of melatonin on imidacloprid-induced pyroptosis and ferroptosis by mediating peptidoglycan in the gut of the common carp (Cyprinus carpio)

Pesticide Biochemistry and Physiology, Journal Year: 2024, Volume and Issue: 202, P. 105935 - 105935

Published: April 28, 2024

Language: Английский

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Does Dietary Supplementation With Quercetin or Rutin Impact Growth, Stress, and Immunity in Pikeperch (Sander lucioperca) and the Water Microbial Community in Recirculating Aquaculture?

Aquaculture Research, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

Pikeperch Sander lucioperca is a species mainly reared in recirculating aquaculture systems (RASs), but it remains very sensitive to stress and handling. Plant phenolic compounds such as quercetin or rutin are frequently investigated feed additives improve the growth well‐being of fish RAS, their impact on pikeperch RAS microbial communities has never been studied. Our objectives were (i) test effect addition (2.2 g kg −1 diet) growth, stress, innate immunity (ii) assess consequence those water communities. 307 (±45) starting weight nine experimental ( n = 3) fed for 84 days diet enriched not (control treatment) with (feeding rate: 1.5%). Considering start (T0) end (T84) experiment, we compare conversion ratio (FCR), morphoanatomical physiological status, diversity composition through metabarcoding approach performed 16S rRNA gene. Whereas no was recorded (624.0 ± 21.9 final weight), (558.0 10.7 weight) reduced (0.54 vs. 0.69%–0.64% day ), increased FCR (1.70 1.2–1.4) compared control (622.0 16.8 treatments, respectively. No observed all parameters analyzed separately, multifactorial analysis reveals that have different overall state. Quercetin induced shift community structure composition, whereas there treatments richness evenness. A dietary supplementation negative physiology modifies RAS. Effects being species‐dependent, precautions must be taken when formulating supplements, which based precise studies.

Language: Английский

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Molecular Mechanism of Action of Abamectin on Human Microglia Clone 3 Cell Line

Applied In Vitro Toxicology, Journal Year: 2025, Volume and Issue: 11(1), P. 16 - 20

Published: Feb. 20, 2025

Introduction: Abamectin (ABA) is an insecticide that commonly used in agricultural spraying. Although it known to have neurotoxic effects on living organisms the ecosystem and humans, details of these effects, including duration amount exposure, are not fully understood. The aim this study evaluate effect ABA exposure human microglia clone 3 (HMC3) cells. These cells were chosen because they suitable for modeling immunological functions such as cytokine production, cell migration, inflammation response.

Language: Английский

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Protective efficacy of quercetin against mercury-mediated toxic impact on the hepatic-renal system of economically important food fish rohu (Labeo rohita)

Aquaculture International, Journal Year: 2025, Volume and Issue: 33(3)

Published: March 12, 2025

Language: Английский

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Quercetin alleviates the toxicity of difenoconazole to the respiratory system of carp by reducing ROS accumulation and maintaining mitochondrial dynamic balance

Toxicology and Applied Pharmacology, Journal Year: 2024, Volume and Issue: 484, P. 116860 - 116860

Published: Feb. 10, 2024

Language: Английский

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Ferulic acid alleviates avermectin induced renal injury in carp by inhibiting inflammation, oxidative stress and apoptosis

Fish & Shellfish Immunology, Journal Year: 2024, Volume and Issue: 149, P. 109575 - 109575

Published: April 24, 2024

Language: Английский

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Dietary additive ferulic acid alleviated oxidative stress, inflammation, and apoptosis induced by chronic exposure to avermectin in the liver of common carp (Cyprinus carpio)

Toxicon, Journal Year: 2024, Volume and Issue: 244, P. 107755 - 107755

Published: May 11, 2024

Language: Английский

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The alleviation of difenoconazole-induced kidney injury in common carp (Cyprinus carpio) by Silybin: involvement of inflammation, oxidative stress, and apoptosis

Fish & Shellfish Immunology, Journal Year: 2024, Volume and Issue: 152, P. 109782 - 109782

Published: Sept. 1, 2024

Language: Английский

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Neurodegenerative Proteinopathies Induced by Environmental Pollutants: Heat Shock Proteins and Proteasome as Promising Therapeutic Tools

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(8), P. 2048 - 2048

Published: July 30, 2023

Environmental pollutants' (EPs) amount and diversity have increased in recent years due to anthropogenic activity. Several neurodegenerative diseases (NDs) are theorized be related EPs, as their incidence has a similar way human EPs exposure they reproduce the main ND hallmarks. induce several neurotoxic effects, including accumulation gradual deposition of misfolded toxic proteins, producing neuronal malfunction cell death. Cells possess different mechanisms eliminate these heat shock proteins (HSPs) proteasome system. The deleterious effects induced through HSPs disruption proteins' homeostatic function by EPs. A therapeutic approach been proposed reduce treatment with recombinant HSPs/proteasome or use compounds that increase expression Our aim is review current literature on NDs EP relationship system HSPs, well discuss dysfunction contradictory described literature. Lastly, we cover developed drugs proteasome/HSPs prevent/treat EP-induced neurodegeneration.

Language: Английский

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