Impact of sub-lethal Aclonifen intoxication on biochemical and stress markers on Oncorhynchus mykiss: an integrative assessment of multi-biomarker responses DOI

Reham Al Horani,

Demet Doğan

Toxicology Research, Journal Year: 2024, Volume and Issue: 14(1)

Published: Dec. 23, 2024

Abstract Aclonifen is a diphenyl ether herbicide being included in the list of priority substances. Nevertheless, data related to its sublethal effects on fish are limited. Therefore, present study has been carried out investigate toxic aclonifen juvenile Oncorhynchus mykiss following 24, 48, 72 and 96 hours application concentrations 12.7, 63.5 127 μg/L. The resulted altered blood biochemistry appearing as hyperglycemia, decreased cholesterol induced activities transaminases ALT AST. inhibition AChE brain, gill liver was unimportant revealing weak potential anticholinesterase. induction recorded for SOD, CAT, GPx GST accompanied with sustained elevation TBARS PC levels. It demonstrates both pro-oxidant oxidation lipid proteins resulting loss membrane integrity protein function. Hyperglycemic condition levels might be proposed general adaptive responses compensate increased energy demand. integrative assessment multi-biomarker shows concentration duration rise calculated indexes. SOD achieved maximum scores liver, respectively. Considering results, oxidative stress inducing anticholinesterase activity along disturbing impact were evidenced. Moreover, adverse affects observed after short term O. mykiss, risk may cause at population level aquatic ecosystems emphasizing importance pesticide regulations avoid impacts non-target species.

Language: Английский

Adverse effects of fenpropathrin on the intestine of common carp (Cyprinus carpio L.) and the mechanism involved DOI

Wenyao Xiu,

Weikai Ding,

Shaoyu Mou

et al.

Pesticide Biochemistry and Physiology, Journal Year: 2024, Volume and Issue: 199, P. 105799 - 105799

Published: Jan. 25, 2024

Language: Английский

Citations

10
Fenpropathrin disrupted the gills of common carp (Cyprinus carpio L.) through oxidative stress, inflammatory responses, apoptosis, and transcriptional alterations DOI Creative Commons
Wenhua Wang,

Shaoyu Mou,

Wenyao Xiu

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 271, P. 116007 - 116007

Published: Jan. 26, 2024

Fenpropathrin (FEN) is an extensively utilized synthetic pyrethroid insecticide frequently found in aquatic ecosystems. However, the adverse effects and potential mechanisms of FEN on species are poorly understood. In this work, common carp were treated with at concentrations 0.45 1.35 μg/L for 14 days, after which tissue structure, physiological alterations, mRNA transcriptome gills evaluated. Specifically, exposure caused pathological damage to carp, downregulated levels claudin-1, occludin, zonula occluden-1 (ZO-1), inhibited Na

Language: Английский

Citations

6
Downregulation of Ambra1 by altered DNA methylation exacerbates dopaminergic neuron damage in a fenpropathrin-induced Parkinson-like mouse model DOI Creative Commons
Songzhe He, Qi Qu, Xi Chen

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 271, P. 115995 - 115995

Published: Jan. 20, 2024

Language: Английский

Citations

5
Risk Assessment of Fenpropathrin: Cause Hepatotoxicity and Nephrotoxicity in Common Carp (Cyprinus carpio L.) DOI Open Access

Gongming Zhu,

Zhihui Liu, Hao Wang

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(18), P. 9822 - 9822

Published: Sept. 11, 2024

The synthetic pyrethroid pesticide fenpropathrin (FEN) is extensively used worldwide and has frequently been detected in biota the environment, whilst negative effects toxicological mechanisms of FEN on non-target organisms are still unknown. In present study, healthy immature common carp were treated with (0.45 1.35 μg/L) for a duration 14 days, impacts possible fish investigated. Biochemical analyses results showed that exposure altered levels glucose (GLU), total cholesterol (T-CHO), triglyceride (TG), albumin (ALB), alkaline phosphatase (ALP), alanine transaminase (ALT), aspartate (AST) serum, caused histological injury liver kidney, indicating may cause hepatotoxicity nephrotoxicity carp. addition, also activities superoxide dismutase (SOD) catalase (CAT) upregulated reactive oxygen species (ROS), elevated malondialdehyde (MDA) kidney. Meanwhile, tumor necrosis factor-α (TNF-α) interleukin-1β (IL-1β) upregulated, oxidative stress inflammatory reaction be involved by FEN. Furthermore, RNA-seq analysis revealed treatment induced diverse array transcriptional changes kidney downregulated differentially expressed genes (DEGs) concentrated multiple pathways, especially cell cycle DNA replication, suggesting induce arrest hepatocytes renal cells, subsequently inducing nephrotoxicity. Overall, study enhances our comprehension toxic provides empirical evidence to support risk assessment organisms.

Language: Английский

Citations

2
Triclosan facilitates the dissemination of antibiotic resistance genes during anaerobic digestion: Focusing on horizontal transfer and microbial response DOI
Panliang Wang, Liuying Li,

Yufei Zhang

et al.

Bioresource Technology, Journal Year: 2024, Volume and Issue: 413, P. 131522 - 131522

Published: Sept. 23, 2024

Language: Английский

Citations

1
Developmental effects of fenpropathrin on zebrafish (Danio rerio) embryo-larvae: Toxic endpoints and potential mechanism DOI
Junguo Ma,

Chunyu Diao,

Yidan Zhang

et al.

Pesticide Biochemistry and Physiology, Journal Year: 2024, Volume and Issue: 208, P. 106262 - 106262

Published: Dec. 17, 2024

Language: Английский

Citations

1
The mechanistic pathway induced by fenpropathrin toxicity: Oxidative stress, signaling pathway, and mitochondrial damage DOI
Soliman Mm, Adel F. Tohamy, Abdelbary Prince

et al.

Journal of Biochemical and Molecular Toxicology, Journal Year: 2024, Volume and Issue: 38(11)

Published: Oct. 17, 2024

Abstract Fenpropathrin (FNP) is a kind of insecticide and acaricide known as pyrethroid. It very effective, has wide range activities, works quickly. Internationally, it commonly considered the most powerful pyrethroid insecticide. Nevertheless, an increasing amount data indicates substantial link between adverse effects on nontarget species, including liver toxicity, kidney nerve damage, reproductive toxicity. Oxidative stress plays vital role in toxicity fenpropathrin, addition to its mechanical mechanism. This study offers thorough examination harmful oxidative mitochondrial processes, well signaling pathways involved these effects. The significant impact emphasizes Fenpropathrin.

Language: Английский

Citations

0
Comparative study of fenpropathrin and its main metabolite in soil-earthworm microcosms: Toxicity, degradation, transcriptome, and oxidative stress DOI
Ping Zhang,

Lulu Ran,

Cancan Yang

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 956, P. 177354 - 177354

Published: Nov. 7, 2024

Language: Английский

Citations

0
Impact of sub-lethal Aclonifen intoxication on biochemical and stress markers on Oncorhynchus mykiss: an integrative assessment of multi-biomarker responses DOI

Reham Al Horani,

Demet Doğan

Toxicology Research, Journal Year: 2024, Volume and Issue: 14(1)

Published: Dec. 23, 2024

Abstract Aclonifen is a diphenyl ether herbicide being included in the list of priority substances. Nevertheless, data related to its sublethal effects on fish are limited. Therefore, present study has been carried out investigate toxic aclonifen juvenile Oncorhynchus mykiss following 24, 48, 72 and 96 hours application concentrations 12.7, 63.5 127 μg/L. The resulted altered blood biochemistry appearing as hyperglycemia, decreased cholesterol induced activities transaminases ALT AST. inhibition AChE brain, gill liver was unimportant revealing weak potential anticholinesterase. induction recorded for SOD, CAT, GPx GST accompanied with sustained elevation TBARS PC levels. It demonstrates both pro-oxidant oxidation lipid proteins resulting loss membrane integrity protein function. Hyperglycemic condition levels might be proposed general adaptive responses compensate increased energy demand. integrative assessment multi-biomarker shows concentration duration rise calculated indexes. SOD achieved maximum scores liver, respectively. Considering results, oxidative stress inducing anticholinesterase activity along disturbing impact were evidenced. Moreover, adverse affects observed after short term O. mykiss, risk may cause at population level aquatic ecosystems emphasizing importance pesticide regulations avoid impacts non-target species.

Language: Английский

Citations

0