Protective effect of melatonin on imidacloprid-induced pyroptosis and ferroptosis by mediating peptidoglycan in the gut of the common carp (Cyprinus carpio)

Pesticide Biochemistry and Physiology, Journal Year: 2024, Volume and Issue: 202, P. 105935 - 105935

Published: April 28, 2024

Language: Английский

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Insights into chlorantraniliprole exposure via activating cytochrome P450-mediated xenobiotic metabolism pathway in the Procambarus clarkii: Identification of P450 genes involved in detoxification

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 277, P. 134231 - 134231

Published: July 27, 2024

Language: Английский

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Co-exposure of decabromodiphenyl ethane and polystyrene nanoplastics damages grass carp (Ctenopharyngodon idella) hepatocytes: Focus on the role of oxidative stress, ferroptosis, and inflammatory reaction

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 940, P. 173575 - 173575

Published: May 31, 2024

Language: Английский

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Cordycepin Ameliorates Renal Interstitial Fibrosis by Inhibiting Drp1-Mediated Mitochondrial Fission

Drug Design Development and Therapy, Journal Year: 2025, Volume and Issue: Volume 19, P. 1271 - 1287

Published: Feb. 1, 2025

This study aimed to investigate the mechanisms and specific targets of cordycepin in treatment renal fibrosis using a unilateral ischemia-reperfusion (UIR) model. A UIR mouse model was established, followed by intraperitoneal injections Mdivi-1. Masson's trichrome staining PAS were used identify tubulointerstitial assess degree injury. Fibrosis markers mitochondrial dynamics-related proteins evaluated Western blotting, while differential gene expression pathway enrichment analyzed RNA-seq. Molecular docking, molecular dynamics simulations surface plasmon resonance conducted validate binding sites on target protein Drp1. Immunofluorescence vitro experiments further elucidated therapeutic mechanism cordycepin. In vivo showed that injection significantly reduced inflammation fibrosis, lowered serum creatinine levels, decreased collagen deposition. Transcriptome analysis revealed downregulated fission upregulated fusion pathway. blotting levels α-SMA FN, as well downregulation Drp1, MFF, Fis1, upregulation OPA1 Mfn2. vitro, inhibited TGF-β-induced injury NRK-52E cells, reducing Drp1 IL-6 secretion. Crosstalk confirmed crucial for anti-fibrotic effects suppressing fibroblast activation. Cordycepin ameliorates targeting inhibit injured tubular epithelial secretion inhibiting

Language: Английский

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New Insights into Melatonin’s Function on Thiacloprid-Induced Pyroptosis and Inflammatory Response in Head Kidney Lymphocytes of Cyprinus carpio: Implicating Mitochondrial Metabolic Imbalance and mtROS/cGAS-STING/NF-κB Axis

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 16, 2025

Thiacloprid (THI) is a synthetic insecticide, the misuse targeted chiefly to control aphid pest species in orchards and vegetables. Melatonin (MET) hormone that plays crucial physiological roles anti-inflammatory capacities of fish. We explored function MET (100 μM) mitigate toxicity induced by THI (20 lymphocytes. Our results indicate led notable rise lymphocyte mortality. Lymphocytes exposed exhibited heightened incidence pyroptosis, accompanied upregulation expression associated with pyroptosis (NLRP3, GSDMEA, IL-18). Meanwhile, exposure decrease mitochondrial membrane potential, an increase mtROS levels, reduction intracellular ATP, DNA, NADPH/NADP+ indicating imbalance metabolism within Additionally, these effects were reversed treatment, where MitoQ treatment showed suppression reduced caused via mtROS/cGAS-STING/NF-κB axis. Importantly, provided defense against immunotoxic impacts ameliorating enhancing capability research potentiates safeguarding cultured fish from biological hazards highlights valuable application common carp.

Language: Английский

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Dietary supplementation of Lactobacillus casei alleviates permethrin exposure-induced zebrafish testis damage through modulation of TLR4/NF-κB and AKT/Nrf2 pathways: Oxidative stress, inflammation and ferroptosis

Pesticide Biochemistry and Physiology, Journal Year: 2025, Volume and Issue: unknown, P. 106450 - 106450

Published: May 1, 2025

Language: Английский

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Hippo-YAP/TAZ-ROS signaling axis regulates metaflammation induced by SelenoM deficiency in high-fat diet-derived obesity

Journal of Advanced Research, Journal Year: 2024, Volume and Issue: unknown

Published: June 1, 2024

Metabolic inflammation (metaflammation) in obesity is primarily initiated by proinflammatory macrophage infiltration into adipose tissue. SelenoM contributes to the modulation of antioxidative stress and multiple pathological processes; however, its roles metaflammation (M1)-like state tissue have not been determined. We hypothesize that could effectively regulate via Hippo-YAP/TAZ-ROS signaling axis derived from a high-fat diet. Morphological changes were examined hematoxylin-eosin (H&E) staining fluorescence microscopy. The glucose tolerance test (GTT) insulin (ITT) used evaluate impact deficiency on blood levels. RNA-Seq analysis, LC-MS Mass spectrometry analysis western blotting performed detect levels genes proteins related glycolipid metabolism Herein, we evaluated inflammatory features metabolic microenvironment mice with SelenoM-deficient tissues multi-omics analyses. deletion resulted disturbances resistance, thereby accelerating weight gain, adiposity, hyperglycemia. Mice lacking white adipocytes developed severe adipocyte hypertrophy impaired lipolysis. aggravated generation ROS reducing equivalents (NADPH glutathione) adipocytes, promoting cytokine production M1-proinflammatory reaction, which was change nuclear factor kappa-B (NF-κB) macrophages. Mechanistically, promoted Hippo-YAP/TAZ-ROS-mediated transcriptional regulation targeting large tumor suppressor 2 (LATS2). Moreover, supplementation N-acetyl cysteine (NAC) reduce excessive oxidative partially rescued responses M1 activation. Our data indicate ameliorates mainly obesity. identification as key regulator presents opportunities for development novel therapeutic interventions dysfunction

Language: Английский

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Oxidative stress-mediated tetrabromobisphenol A disrupts mitochondrial function in HepG2 cells and activates ferroptosis signalling to induce apoptosis

Journal of Environmental Management, Journal Year: 2025, Volume and Issue: 382, P. 125360 - 125360

Published: April 14, 2025

Language: Английский

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Mitochondrial Dysfunction in Environmental Toxicology: Mechanisms, Impacts, and Health Implications

Chemical Research in Toxicology, Journal Year: 2024, Volume and Issue: 37(11), P. 1794 - 1806

Published: Nov. 1, 2024

Mitochondria, pivotal to cellular metabolism, serve as the primary sources of biological energy and are key regulators intracellular calcium ion storage, crucial for maintaining homeostasis. Dysfunction in these organelles impairs ATP synthesis, diminishing functionality. Emerging evidence implicates mitochondrial dysfunction etiology progression diverse diseases. Environmental factors that induce dysregulation raise significant public health concerns, necessitating a nuanced comprehension classification mitochondrial-related hazards. This review systematically adopts toxicological perspective illuminate functions mitochondria, offering comprehensive exploration how toxicants instigate dysfunction. It delves into disruption initiation fragility autophagy, induction mutations DNA by mutagens. The overarching objective is enhance our understanding repercussions damage on human health.

Language: Английский

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Dietary Lactobacillus Casei Alleviated Oxidative Stress, Inflammation and Ferroptosis in Zebrafish Testis that Was Induced by Environmentally Relevant Concentrations of Permethrin Exposure Via Regulation of Tlr4/Nf-Κb and Akt/Nrf2 Pathways

Published: Jan. 1, 2024

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Language: Английский

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