Transcription factor BbCDR1 regulates the orchestration between conidial formation and maturation in the entomopathogenic fungus Beauveria bassiana

Pest Management Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 24, 2025

Abstract BACKGROUND The entomopathogenic fungus Beauveria bassiana has been widely used for pest biocontrol with conidia serving as the main active agents. Conidial yield and quality are two important characteristics in fungal development, however, regulatory mechanisms that orchestrate conidial formation development not well understood. RESULTS In this study, we identified a Zn 2 Cys 6 transcription factor BbCDR1 inhibits production while promoting maturation. Compared wild type, ΔBbCDR1 mutant exhibited 1.88‐fold increase but reduction quality, including decreased cell wall integrity trehalose synthesis. deletion of also led to reduced germination rates under oxidative, osmotic, disruption UV stresses. Interestingly, an virulence 12.5% decrease LT 50 compared type. CONCLUSIONS Further analysis revealed represses expression BbbrlA activates BbwetA , components central developmental pathway (CDP) regulate initiation maturation, respectively. These findings suggest plays crucial role new target gene genetic engineering highly insecticides. © 2025 Society Chemical Industry.

Language: Английский

A novel fungal sensor (Ngs1) of N-acetylglucosamine (GlcNAc) mediates the fungal response to GlcNAc in the interaction between entomopathogenic Beauveria bassiana and insect host

Journal of Invertebrate Pathology, Journal Year: 2024, Volume and Issue: unknown, P. 108206 - 108206

Published: Sept. 1, 2024

Language: Английский

N-acetylglucosamine sensor, Ngs1 contributes to Beauveria bassiana vegetative growth, oxidative phosphorylation, fungal development, and cell wall integrity during entomopathogen-insect interaction

Pesticide Biochemistry and Physiology, Journal Year: 2024, Volume and Issue: 208, P. 106273 - 106273

Published: Dec. 24, 2024

Language: Английский