The paraventricular thalamus mediates visceral pain and anxiety-like behaviors via two distinct pathways DOI Creative Commons
Di Li, Yongchang Li,

Zhengyan Zhu

et al.

Neuron, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Chronic visceral pain (CVP) often accompanies emotional disorders. However, the lack of suitable animal models has hindered research into their underlying molecular and neural circuitry mechanisms. Early-life stress is a key factor in developing both hypersensitivity disorders, yet its pathological mechanisms are not well understood. This study showed that adult offspring prenatal maternal (PMS)-exposed mice exhibited anxiety-like behaviors. Glutamatergic neurons anterior paraventricular thalamus (aPVT) responded to pain, while those posterior PVT (pPVT) were more responsive anxiety. The aPVT-basolateral amygdala (BLA) pPVT-central (CeA) circuits regulated CVP anxiety, respectively. Notably, increased Cacna1e expression aPVT enhanced Grin2a upregulation pPVT facilitated only These findings highlight distinct roles aPVTGlu-BLAGlu-CeAGABA pPVTGlu-CeAGABA circuits, providing insights for therapeutic approaches anxiety comorbidity.

Language: Английский

Neuroanatomical and functional substrates of the short video addiction and its association with brain transcriptomic and cellular architecture DOI Creative Commons

Yuanyuan Gao,

Ying Hu,

Jinlian Wang

et al.

NeuroImage, Journal Year: 2025, Volume and Issue: 307, P. 121029 - 121029

Published: Jan. 17, 2025

Language: Английский

Citations

2
The Paraventricular Nucleus of the Thalamus Is an Important Node in the Emotional Processing Network DOI Creative Commons
Jessica R. Barson, Nancy R. Mack, Wen‐Jun Gao

et al.

Frontiers in Behavioral Neuroscience, Journal Year: 2020, Volume and Issue: 14

Published: Oct. 29, 2020

The paraventricular nucleus of the thalamus (PVT) has for decades been acknowledged to be an important node in limbic system, but studies emotional processing generally fail incorporate it into their investigational framework. Here, we propose that PVT should considered as integral part network. Through its distinct subregions, cell populations, and connections with other nuclei, participates both major features emotion: arousal valence. PVT, particularly anterior can through neuronal activity promote arousal, sleep-wake cycle response novel stimuli. It is also involved reward, being responsive rewarding stimuli itself affecting behavior reflecting likely via specific populations cells distributed throughout subregions. Similarly, contributes depression-like behavior, yet undefined posterior particular demonstrates a role anxiety-like promoting inhibiting this behavior. This subregion especially stressors, functions suppress stress following chronic exposure. In addition participating unconditioned or primary responses, makes contributions conditioned Neuronal reward-predictive cue detected endogenous strongly predicts approach seeking during fear retrieval activation facilitates expression fear. Much involvement valence shown occur same general afferents efferents, including hypothalamus, prelimbic infralimbic cortices, accumbens, amygdala, although detailed functional map circuits control responses remains delineated. Thus, while caveats exist more work required, extensive prominent nuclei appears

Language: Английский

Citations

103
Refocusing neuroscience: moving away from mental categories and towards complex behaviours DOI Creative Commons
Luiz Pessoa, Loreta Medina, Ester Desfilis

et al.

Philosophical Transactions of the Royal Society B Biological Sciences, Journal Year: 2021, Volume and Issue: 377(1844)

Published: Dec. 27, 2021

Mental terms-such as perception, cognition, action, emotion, well attention, memory, decision-making-are epistemically sterile. We support our thesis based on extensive comparative neuroanatomy knowledge of the organization vertebrate brain. Evolutionary pressures have moulded central nervous system to promote survival. Careful characterization brain shows that its architecture supports an enormous amount communication and integration signals, especially in birds mammals. The general a degree 'computational flexibility' enables animals cope successfully with complex ever-changing environments. Here, we suggest neuroarchitecture does not respect boundaries standard mental terms, propose neuroscience should aim unravel dynamic coupling between large-scale circuits complex, naturalistic behaviours. This article is part theme issue 'Systems through lens evolutionary theory'.

Language: Английский

Citations

91
Cocaine-induced projection-specific and cell type-specific adaptations in the nucleus accumbens DOI
Alexander K. Zinsmaier, Yan Dong, Yanhua H. Huang

et al.

Molecular Psychiatry, Journal Year: 2021, Volume and Issue: 27(1), P. 669 - 686

Published: May 7, 2021

Language: Английский

Citations

75
Reward and aversion processing by input-defined parallel nucleus accumbens circuits in mice DOI Creative Commons
Kuikui Zhou, Hua Xu, Shanshan Lu

et al.

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Oct. 21, 2022

Abstract The nucleus accumbens (NAc) is critical in mediating reward seeking and also involved negative emotion processing, but the cellular circuitry mechanisms underlying such opposing behaviors remain elusive. Here, using recently developed AAV1-mediated anterograde transsynaptic tagging technique mice, we show that NAc neurons receiving basolateral amygdala inputs (NAc BLA ) promote positive reinforcement via disinhibiting dopamine ventral tegmental area (VTA). In contrast, paraventricular thalamic PVT innervate GABAergic lateral hypothalamus (LH) mediate aversion. Silencing synaptic output of impairs behavior, while silencing or →LH pathway abolishes aversive symptoms opiate withdrawal. Our results elucidate afferent-specific circuit architecture controlling

Language: Английский

Citations

66
Structural and functional organization of the midline and intralaminar nuclei of the thalamus DOI Creative Commons
Robert P. Vertes, Stephanie B. Linley,

Amanda K. P. Rojas

et al.

Frontiers in Behavioral Neuroscience, Journal Year: 2022, Volume and Issue: 16

Published: Aug. 23, 2022

The midline and intralaminar nuclei of the thalamus form a major part "limbic thalamus;" that is, thalamic structures anatomically functionally linked with limbic forebrain. consist paraventricular (PV) paratenial nuclei, dorsally rhomboid nucleus reuniens (RE), ventrally. rostral (ILt) central medial (CM), paracentral (PC) lateral (CL) nuclei. We presently concentrate on RE, PV, CM CL thalamus. receives diverse array input from limbic-related sites, predominantly projects to hippocampus "limbic" cortices. RE participates in various cognitive functions including spatial working memory, executive (attention, behavioral flexibility) affect/fear behavior. PV significant afferents, particularly hypothalamus, mainly distributes "affective" forebrain bed stria terminalis, accumbens amygdala. Accordingly, serves critical role "motivated behaviors" such as arousal, feeding/consummatory behavior drug addiction. ILt both sensorimotor-related widely over motor regions frontal cortex-and throughout dorsal striatum. is for maintaining consciousness directly sensorimotor (visuospatial or reaction time tasks) tasks involving striatal-cortical interactions. As discussed herein, while each are distinct, they collectively serve vital several affective, behaviors - components brainstem-diencephalic-thalamocortical circuitry.

Language: Английский

Citations

41
Microbiota-gut-brain axis drives overeating disorders DOI Creative Commons
Sijia Fan, Weiwei Guo,

Dan Xiao

et al.

Cell Metabolism, Journal Year: 2023, Volume and Issue: 35(11), P. 2011 - 2027.e7

Published: Oct. 3, 2023

Language: Английский

Citations

40
Endocannabinoids facilitate transitory reward engagement through retrograde gain control DOI Open Access
David J. Marcus,

Anthony E. English,

Ge Chun

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Neuromodulatory signaling is poised to serve as a neural mechanism for gain control, acting crucial tuning factor influence neuronal activity by dynamically shaping excitatory and inhibitory fast neurotransmission. The endocannabinoid (eCB) system, the most widely expressed neuromodulatory system in mammalian brain, known filter inputs through retrograde, pre-synaptic action. However, whether eCBs exert retrograde control ultimately facilitate reward-seeking behaviors freely moving mammals not established. Using suite of vivo physiological, imaging, genetic machine learning-based approaches, we report fundamental role controlling behavioral engagement behavior defined thalamo-striatal circuit.

Language: Английский

Citations

1
Regulation of PVT‐CeA Circuit in Deoxynivalenol‐Induced Anorexia and Aversive‐Like Emotions DOI Creative Commons
Liu‐Nan Yang,

Mingmeng Tang,

Andreas K. Nüssler

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 28, 2025

Abstract Neuronal plasticity in the central amygdala (CeA) is essential for modulating feeding behaviors and emotional responses, potentially influencing reactions to Deoxynivalenol (DON). Acute oral administration of DON elicits a dose‐responsive reduction food intake, accompanied by pronounced alterations locomotor activity frequency. This study investigates circuitry adaptations that mediate DON's effects on feeding, targeting GABA neurons CeA. Following exposure DON, an increase connectivity between paraventricular nucleus thalamus (PVT) CeA observed, suggesting involvement this pathway adverse states. Chemogenetic optogenetic manipulations resulted substantial mice's overall activity. These findings suggest are involved DON‐induced anorexia aversive‐like responses. Additionally, SCN10A antagonist (A‐803467) effectively mitigated emotions, highlighting pivotal role PVT‐CeA circuit regulating physiological impacts DON. have significant implications public health clinical interventions, offering potential therapeutic strategies mitigate human health.

Language: Английский

Citations

1
Heterogeneity in the Paraventricular Thalamus: The Traffic Light of Motivated Behaviors DOI Creative Commons
Jacqueline F. McGinty, James M. Otis

Frontiers in Behavioral Neuroscience, Journal Year: 2020, Volume and Issue: 14

Published: Oct. 16, 2020

The paraventricular thalamic nucleus (PVT) is highly interconnected with brain areas that control reward-seeking behavior. Despite this known connectivity, broad manipulations of PVT often lead to mixed, and even opposing, behavioral effects, clouding our understanding how precisely contributes reward processing. Although the function in influencing poorly understood, recent studies show forebrain hypothalamic inputs to, accumbens amygdalar outputs from, are strongly implicated responses conditioned appetitive or aversive stimuli determine whether an animal will approach avoid specific rewards. These studies, which have used array chemogenetic, optogenetic, calcium imaging technologies, shown activity input output circuits heterogeneous, mixed patterns contribute behavior distinct manners. Thus, it important perform experiments defined cell types elucidate network behaviors. In review, we describe complex heterogeneity within circuitry appears influence decision seek a point out gaps should be investigated future studies.

Language: Английский

Citations

62