Distinct reward processing by subregions of the nucleus accumbens

Cell Reports, Journal Year: 2023, Volume and Issue: 42(2), P. 112069 - 112069

Published: Feb. 1, 2023

The nucleus accumbens (NAc) plays an important role in motivation and reward processing. Recent studies suggest that different NAc subnuclei differentially contribute to reward-related behaviors. However, how is encoded individual neurons remains unclear. Using vivo single-cell resolution calcium imaging, we find diverse patterns of encoding the medial lateral shell subdivision (NAcMed NAcLat, respectively). Reward consumption increases NAcLat activity but decreases NAcMed activity, albeit with high variability among neurons. heterogeneity could be attributed differences their synaptic inputs transcriptional profiles. Specific optogenetic activation Nts-positive promotes positive reinforcement, while Cartpt-positive induces behavior aversion. Collectively, our study shows organizational subregions provides a framework for future dissection physiological pathological conditions.

Language: Английский

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Nucleus accumbens circuit disinhibits lateral hypothalamus glutamatergic neurons contributing to morphine withdrawal memory in male mice

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Jan. 5, 2023

The lateral hypothalamus (LH) is physiologically critical in brain functions. LH also plays an important role drug addiction. However, neural circuits underlying involvement of addiction remain obscure. In the present study,our results showed that male mice, during context-induced expression morphine withdrawal memory, glutamatergic neurons played role; dopamine D1 receptor-expressing medium spiny (D1-MSNs) projecting from core nucleus accumbens (NAcC) to were upstream circuit activate neurons; D1-MSNs NAcC activated through inhibiting local gamma-aminobutyric acid (GABA) neurons. These suggest disinhibited by importantly contribute memory.

Language: Английский

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The nucleus accumbens in reward and aversion processing: insights and implications

Frontiers in Behavioral Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: Aug. 9, 2024

The nucleus accumbens (NAc), a central component of the brain's reward circuitry, has been implicated in wide range behaviors and emotional states. Emerging evidence, primarily drawing from recent rodent studies, suggests that function NAc aversion processing is multifaceted. Prolonged stress or drug use induces maladaptive neuronal which results pathological conditions. This review aims to provide comprehensive up-to-date insights on role motivated behavior regulation highlights areas demand further in-depth analysis. It synthesizes latest findings how distinct populations pathways contribute opposite valences. examines neuromodulators, especially monoamines, influence NAc's control over various motivational Furthermore, it delves into complex underlying mechanisms psychiatric disorders such as addiction depression evaluates prospective interventions restore functionality.

Language: Английский

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Changes in nucleus accumbens core translatome accompanying incubation of cocaine craving

Neuropsychopharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: April 29, 2025

Language: Английский

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Membrane excitability of nucleus accumbens neurons gates the incubation of cocaine craving

Neuropsychopharmacology, Journal Year: 2023, Volume and Issue: 48(9), P. 1318 - 1327

Published: April 11, 2023

Language: Английский

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Regulation of cocaine-related behaviours by estrogen and progesterone

Neuroscience & Biobehavioral Reviews, Journal Year: 2022, Volume and Issue: 135, P. 104584 - 104584

Published: Feb. 19, 2022

Language: Английский

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Cell-type specific synaptic plasticity in dorsal striatum is associated with punishment-resistance compulsive-like cocaine self-administration in mice

Neuropsychopharmacology, Journal Year: 2022, Volume and Issue: 48(3), P. 448 - 458

Published: Sept. 7, 2022

Abstract Addiction-related compulsion-like behavior can be modeled in rodents with drug self-administration (SA) despite harmful consequences. Recent studies suggest that the potentiation of glutamatergic transmission at orbitofrontal cortex (OFC) to dorsal striatum (DS) synapses drives transition from controlled SA. However, timing induction this synaptic plasticity remains elusive. Here, mice were first allowed intravenously self-administer cocaine. When had endure a risk electrical foot shock, only fraction persevered cocaine In these persevering mice, we recorded high A/N ratios (AMPA-R/NMDA-R: α-amino-3hydroxy-5-methyl-4-isoxazolepropionic acid receptor/N-methyl-D-aspartate receptor) both types spiny projection neurons (i.e., D1 and D2 dopamine receptor-expressing SPNs). By contrast, when prepared slices end acquisition period, all was D1R- but not D2R-SPNs. These results indicate SA emerges during punishment sessions, where onto D2R-SPNs are strengthened. renouncing individuals, cocaine-evoked strengthening D1R-SPNs is lost. Our study thus reveals cell-type specific sequence eventually may cause

Language: Английский

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Whole-brain tracking of cocaine and sugar rewards processing

Translational Psychiatry, Journal Year: 2023, Volume and Issue: 13(1)

Published: Jan. 23, 2023

Abstract Natural rewards, such as food, and sex are appetitive stimuli available for animals in their natural environment. Similarly, addictive rewards drugs of abuse possess strong, positive valence, but action relies on pharmacological properties. Nevertheless, it is believed that both these kinds activate similar brain circuitry. The present study aimed to discover which parts the process experience rewards. To holistically address this question, we used a single-cell whole-brain imaging approach find patterns activation acute prolonged sucrose cocaine exposure. We analyzed almost 400 structures created brain-wide map specific, c-Fos-positive neurons engaged by Acute not exposure triggered massive c-Fos expression throughout brain. Cocaine other hand potentiated with use, engaging more than treatment. functional connectivity analysis unraveled an increase modularity after initial types This was increased repeated cocaine, sucrose, intake. check whether discrepancies between processing can be found cellular level, further studied nucleus accumbens, one most strongly activated experience. high overlap level expression. Electrophysiological measurements correlates synaptic plasticity revealed alike induce accumulation silent synapses. These results strengthen hypothesis accumbens cause maladaptive neuronal circuitry typically processes

Language: Английский

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NPAS4 supports cocaine-conditioned cues in rodents by controlling the cell type-specific activation balance in the nucleus accumbens

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Aug. 8, 2024

Abstract Powerful associations that link drugs of abuse with cues in the drug-paired environment often serve as prepotent relapse triggers. Drug-associated contexts and activate ensembles nucleus accumbens (NAc) neurons, including D1-class medium spiny neurons (MSNs) typically promote, D2-class MSNs oppose, drug seeking. We found mice, cocaine conditioning upregulated transiently activity-regulated transcription factor, Neuronal PAS Domain Protein 4 (NPAS4), a small subset NAc neurons. The NPAS4+ ensemble was required for conditioned place preference. also observed NPAS4 functions within D2-, but not D1-, to support cocaine-context cue-induced cocaine, sucrose, Together, our data show is essential itself D2-MSNs by suppressing drug-induced counteradaptations oppose relapse-related behaviour.

Language: Английский

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Retinoic acid-mediated homeostatic plasticity in the nucleus accumbens core contributes to incubation of cocaine craving

Psychopharmacology, Journal Year: 2024, Volume and Issue: 241(10), P. 1983 - 2001

Published: June 27, 2024

Language: Английский

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