Lycium barbarum L. leaves ameliorate type 2 diabetes in rats by modulating metabolic profiles and gut microbiota composition DOI Creative Commons

Xueqin Zhao,

Sheng Guo,

Youyuan Lu

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2019, Volume and Issue: 121, P. 109559 - 109559

Published: Nov. 14, 2019

The leaf of Lycium barbarum L. (LLB) has been widely used as a tea, vegetable, and herb in China Southeast Asia for centuries; this is because the hypoglycemic effect it has, but mechanism behind still unclear. In study, type 2 diabetic mellitus (T2DM) rat model, induced by high-fat diet combined with low-dose streptozotocin (STZ) injections, was adopted. biochemical index determined histopathological metabolomics analyses serum urine 16S rDNA sequencing gut microbiota were performed. We evaluated effects action water extract from LLB, which contained neochlorogenic acid, chlorogenic caffeic rutin (up to 6.06%). relationships between indexes, metabolites, analyzed. results showed that LLB could noticeably modulate levels blood glucose lipids rats well repair injuries livers, kidneys pancreas. changes metabolites caused T2DM reversed after administration LLB; these found mainly be correlated following pathways: nicotinate nicotinamide metabolism, arachidonic acid purine metabolism. Sequencing fecal samples reverse dysbiosis had induced. Therefore, we conclude T2DM, altered metabolic profiles microbiota, alleviated effectively using extract.

Language: Английский

Rhein modulates host purine metabolism in intestine through gut microbiota and ameliorates experimental colitis DOI Creative Commons
Jiawei Wu, Zhonghong Wei, Peng Cheng

et al.

Theranostics, Journal Year: 2020, Volume and Issue: 10(23), P. 10665 - 10679

Published: Jan. 1, 2020

Background: Gut microbiota, which plays a crucial role in inflammatory bowel diseases (IBD), might have therapeutic benefits for ulcerative colitis or Crohn's disease. Targeting gut microbiota represents new treatment strategy IBD patients. Rhein is one of the main components rhubarb and exhibits poor oral bioavailability but still exerts anti-inflammatory effects some diseases. Therefore, we investigated effect rhein on studied its possible mechanisms. Methods: The chronic mouse model was induced by four rounds 2% dextran sulfate sodium (DSS) treatment. mice were treated with 50 mg/kg 100 daily, body weight, colon length, histological score, cytokines serum intestine, fecal lipocalin 2 concentration determined. Th17 cell, Th1 cell Th2 infiltration mesenteric lymph node analyzed flow cytometry. Metabolic profiles collected non-targeted metabolomics key metabolic pathways identified using MetaboAnalyst 4.0. We also assessed intestinal barrier permeability performed 16s rDNA sequencing. Lactobacillus sp. cultured, transplantation (FMT) employed to evaluate contribution microbiota. Results: could significantly alleviate DSS-induced colitis. Uric acid as modulator led decreased uric levels. determined that changed purine metabolism indirectly, while probiotic involved regulation host metabolism. resulted worsened barrier, be rescued rhein. further confirmed rhein-treated sufficient relieve FMT. Conclusion: showed modulate indirectly intestine subsequently alleviated Our study has approach clinical

Language: Английский

Citations

284
Pharmacological properties and derivatives of shikonin—A review in recent years DOI

Chuanjie Guo,

Junlin He, Xiaominting Song

et al.

Pharmacological Research, Journal Year: 2019, Volume and Issue: 149, P. 104463 - 104463

Published: Sept. 22, 2019

Language: Английский

Citations

275
New opportunities and challenges of natural products research: When target identification meets single-cell multiomics DOI
Yuyu Zhu, Zijun Ouyang, Haojie Du

et al.

Acta Pharmaceutica Sinica B, Journal Year: 2022, Volume and Issue: 12(11), P. 4011 - 4039

Published: Aug. 27, 2022

Language: Английский

Citations

247
Comprehensive relationships between gut microbiome and faecal metabolome in individuals with type 2 diabetes and its complications DOI
Lijuan Zhao, Hong‐Xiang Lou, Ying Peng

et al.

Endocrine, Journal Year: 2019, Volume and Issue: 66(3), P. 526 - 537

Published: Oct. 7, 2019

Language: Английский

Citations

185
Natural medicines for the treatment of fatigue: Bioactive components, pharmacology, and mechanisms DOI

Chuanhong Luo,

Xiaorong Xu,

Xichuan Wei

et al.

Pharmacological Research, Journal Year: 2019, Volume and Issue: 148, P. 104409 - 104409

Published: Aug. 22, 2019

Language: Английский

Citations

184
ACE2 imbalance as a key player for the poor outcomes in COVID-19 patients with age-related comorbidities – Role of gut microbiota dysbiosis DOI Open Access
Sofia Viana, Sara Nunes, Flávio Reis

et al.

Ageing Research Reviews, Journal Year: 2020, Volume and Issue: 62, P. 101123 - 101123

Published: July 16, 2020

Language: Английский

Citations

171
Bioactive components of mushrooms: Processing effects and health benefits DOI
Divya Yadav, Pradeep Singh Negi

Food Research International, Journal Year: 2021, Volume and Issue: 148, P. 110599 - 110599

Published: July 10, 2021

Language: Английский

Citations

155
Baicalin and the liver-gut system: Pharmacological bases explaining its therapeutic effects DOI
Qichao Hu, Wenwen Zhang, Zhao Wu

et al.

Pharmacological Research, Journal Year: 2021, Volume and Issue: 165, P. 105444 - 105444

Published: Jan. 22, 2021

Language: Английский

Citations

148
Interactions between polysaccharides and gut microbiota: A metabolomic and microbial review DOI
Dandan Zhang, Juan Liu, Hao Cheng

et al.

Food Research International, Journal Year: 2022, Volume and Issue: 160, P. 111653 - 111653

Published: July 10, 2022

Language: Английский

Citations

98
Traditional Medicine Pien Tze Huang Suppresses Colorectal Tumorigenesis Through Restoring Gut Microbiota and Metabolites DOI Creative Commons
Hongyan Gou, Hao Su, Dehua Liu

et al.

Gastroenterology, Journal Year: 2023, Volume and Issue: 165(6), P. 1404 - 1419

Published: Sept. 12, 2023

Background & AimsPien Tze Huang (PZH) is a well-established traditional medicine with beneficial effects against inflammation and cancer. We aimed to explore the chemopreventive effect of PZH in colorectal cancer (CRC) through modulating gut microbiota.MethodsCRC mouse models were established by azoxymethane plus dextran sulfate sodium treatment or Apcmin/+ mice treated without (270 mg/kg 540 mg/kg). Gut barrier function was determined means intestinal permeability assays transmission electron microscopy. Fecal microbiota metabolites analyzed metagenomic sequencing liquid chromatography mass spectrometry, respectively. Germ-free antibiotic-treated used as depletion.ResultsPZH inhibited tumorigenesis sodium–treated dose-dependent manner. altered profile, an increased abundance probiotics Pseudobutyrivibrio xylanivorans Eubacterium limosum, while pathogenic bacteria Aeromonas veronii, Campylobacter jejuni, Collinsella aerofaciens, Peptoniphilus harei depleted. In addition, taurine hypotaurine, bile acids, unsaturated fatty significantly restored function. Transcriptomic profiling revealed that PI3K–Akt, interleukin-17, tumor necrosis factor, cytokine–chemokine signaling. Notably, involved both microbiota-dependent -independent mechanisms. transplantation from PZH-treated germ-free partly recapitulated PZH. components ginsenoside-F2 ginsenoside-Re demonstrated inhibitory on CRC cells primary organoids, also mice.ConclusionsPZH manipulated toward more favorable improved function, suppressed oncogenic pro-inflammatory pathways, thereby suppressing carcinogenesis. Pien microbiota. depletion. mice.

Language: Английский

Citations

69