International Immunopharmacology, Journal Year: 2020, Volume and Issue: 87, P. 106807 - 106807
Published: July 16, 2020
Language: Английский
Signal Transduction and Targeted Therapy, Journal Year: 2022, Volume and Issue: 7(1)
Published: July 29, 2022
Abstract Radiotherapy (RT) is delivered for purposes of local control, but can also exert systemic effect on remote and non-irradiated tumor deposits, which called abscopal effect. The view RT as a simple treatment has dramatically changed in recent years, it now widely accepted that provoke immune response gives strong rationale the combination immunotherapy (iRT). Nevertheless, several points remain to be addressed such interaction system, identification best schedules with (IO), expansion mechanism amplify iRT. To answer these crucial questions, we roundly summarize underlying showing whole landscape clinical trials attempt identify In consideration rarity effect, propose occurrence induced by radiation promoted 100% molecular genetic level. Furthermore, “radscopal effect” refers using low-dose reprogram microenvironment may overcome resistance Taken together, could regarded trigger antitumor response, help IO used radical added into current standard regimen patients metastatic cancer.
Language: Английский
Citations
359
Nature reviews. Immunology, Journal Year: 2021, Volume and Issue: 22(2), P. 124 - 138
Published: July 1, 2021
Language: Английский
Citations
160
Journal of Translational Medicine, Journal Year: 2023, Volume and Issue: 21(1)
Published: Oct. 9, 2023
Abstract Cancer remains the leading cause of death around world. In cancer treatment, over 50% patients receive radiotherapy alone or in multimodal combinations with other therapies. One adverse consequences after radiation exposure is occurrence radiation-induced tissue fibrosis (RIF), which characterized by abnormal activation myofibroblasts and excessive accumulation extracellular matrix. This phenotype can manifest multiple organs, such as lung, skin, liver kidney. In-depth studies on mechanisms have shown that a variety signals immune cells release cytokines, intracellular cGAS/STING, oxidative stress response, metabolic reprogramming proteasome pathway are involved myofibroblasts. Tissue extremely harmful to patients' health requires early diagnosis. addition traditional serum markers, histologic imaging tests, diagnostic potential nuclear medicine techniques emerging. Anti-inflammatory antioxidant therapies treatments for fibrosis. Recently, some promising therapeutic strategies emerged, stem cell therapy targeted However, incomplete knowledge hinders treatment this disease. Here, we also highlight mechanistic, directions
Language: Английский
Citations
51
The Journal of Experimental Medicine, Journal Year: 2024, Volume and Issue: 221(7)
Published: May 21, 2024
The majority of cancer patients receive radiotherapy during the course treatment, delivered with curative intent for local tumor control or as part a multimodality regimen aimed at eliminating distant metastasis. A major focus research has been DNA damage; however, in past two decades, emphasis shifted to important role immune system plays radiotherapy-induced anti-tumor effects. Radiotherapy reprograms microenvironment, triggering and RNA sensing cascades that activate innate immunity ultimately enhance adaptive immunity. In opposition, also induces suppression immunity, including recruitment regulatory T cells, myeloid-derived suppressor suppressive macrophages. balance pro- is regulated by chemokines cytokines. Microbiota can influence outcomes under clinical investigation. Blockade PD-1/PD-L1 axis CTLA-4 extensively investigated combination radiotherapy; we include review trials involving inhibition these checkpoints radiotherapy.
Language: Английский
Citations
26
Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 504, P. 215654 - 215654
Published: Jan. 20, 2024
Language: Английский
Citations
19
Cancer Letters, Journal Year: 2024, Volume and Issue: 587, P. 216651 - 216651
Published: Feb. 10, 2024
Language: Английский
Citations
19
International Immunopharmacology, Journal Year: 2020, Volume and Issue: 85, P. 106663 - 106663
Published: June 7, 2020
Language: Английский
Citations
112
International Immunopharmacology, Journal Year: 2020, Volume and Issue: 86, P. 106761 - 106761
Published: July 3, 2020
Language: Английский
Citations
98
Critical Reviews in Oncology/Hematology, Journal Year: 2020, Volume and Issue: 157, P. 103180 - 103180
Published: Nov. 16, 2020
Language: Английский
Citations
92
Frontiers in Chemistry, Journal Year: 2020, Volume and Issue: 8
Published: Oct. 15, 2020
Pancreatic cancer is the most lethal malignancy of gastrointestinal tract. Because its propensity for early local and distant spread, affected patients possess extremely poor prognosis. Currently applied treatments are not effective enough to eradicate all cells, minimize their migration. Besides, these associated with adverse effects on normal cells organs. These therapies able increase overall survival rate patients; hence, finding novel adjuvants or alternatives so essential. Up now, medicinal herbs were utilized therapeutic goals. Herbal-based medicine, as traditional biotherapeutics, was employed treatment. Of them, apigenin, a bioactive flavonoid that possesses numerous biological properties (e.g., anti-inflammatory anti-oxidant effects), has shown substantial anticancer activity. It seems apigenin capable suppressing proliferation via induction cell cycle arrest apoptosis. inhibits metastasis down-regulation matrix metalloproteinases Akt signaling pathway. In pancreatic sensitizes into chemotherapy, affects molecular pathways such hypoxia inducible factor (HIF), vascular endothelial growth (VEGF), glucose transporter-1 (GLUT-1), etc. Herein, biotherapeutic activity mechanisms toward presented in current review shed some light anti-tumor different cancers, an emphasis cancer.
Language: Английский
Citations
91