International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
25(1), P. 251 - 251
Published: Dec. 23, 2023
Apigenin
is
one
of
the
most
widespread
flavonoids
in
plant
kingdom.
For
centuries,
apigenin-containing
preparations
have
been
used
traditional
medicines
to
treat
diseases
that
an
inflammatory
and/or
degenerative
component.
In
1980s,
apigenin
was
proposed
interfere
with
process
carcinogenesis.
Since
then,
more
and
evidence
has
demonstrated
its
anticancer
efficacy,
both
vitro
vivo.
shown
target
signaling
pathways
involved
development
progression
cancer,
such
as
PI3K/Akt/mTOR,
MAPK/ERK,
JAK/STAT,
NF-κB,
Wnt/β-catenin
pathways,
modulate
different
hallmarks
cell
proliferation,
metastasis,
apoptosis,
invasion,
migration.
Furthermore,
modulates
PD1/PD-L1
expression
cancer/T
killer
cells
regulates
percentage
T
regulatory
cells.
Recently,
studied
for
synergic
additive
effects
when
combined
chemotherapy,
minimizing
side
effects.
Unfortunately,
low
bioavailability
high
permeability
limit
therapeutic
applications.
Based
on
micro-
nanoformulations
enhance
physical
stability
drug-loading
capacity
increase
apigenin,
novel
drug-delivery
systems
investigated
improve
solubility.
Journal of Cellular Physiology,
Journal Year:
2022,
Volume and Issue:
237(7), P. 2770 - 2795
Published: May 13, 2022
Metastasis
of
tumor
cells
is
a
complex
challenge
and
significantly
diminishes
the
overall
survival
prognosis
cancer
patients.
The
epithelial-to-mesenchymal
transition
(EMT)
well-known
mechanism
responsible
for
invasiveness
cells.
A
number
molecular
pathways
can
regulate
EMT
in
nuclear
factor-kappaB
(NF-κB)
one
them.
translocation
NF-κB
p65
induce
transcription
several
genes
involved
induction.
present
review
describes
interaction
their
association
progression.
Due
to
oncogenic
role
signaling,
its
activation
enhances
metastasis
via
This
has
been
confirmed
various
cancers
including
brain,
breast,
lung
gastric
cancers,
among
others.
ZEB1/2,
transforming
growth
factor-β,
Slug
as
inducers
undergo
upregulation
by
promote
After
induction
driven
NF-κB,
significant
decrease
occurs
E-cadherin
levels,
while
N-cadherin
vimentin
levels
an
increase.
noncoding
RNAs
potentially
also
function
upstream
mediators
modulate
NF-κB/EMT
axis
cancers.
Moreover,
mediating
drug
resistance
Thus,
suppressing
sensitivity
chemotherapeutic
agents.
Advanced Functional Materials,
Journal Year:
2022,
Volume and Issue:
32(34)
Published: June 24, 2022
Abstract
MXenes
(viz.,
transition
metal
carbides,
carbonitrides,
and
nitrides)
have
emerged
as
a
new
subclass
of
2D
materials.
Due
to
their
outstanding
physicochemical
biological
properties,
gained
much
attention
in
the
biomedical
field
recent
years,
including
drug
delivery
systems,
regenerative
medicine,
biosensing.
Additionally,
incorporation
into
hydrogels
has
garnered
significant
interest
engineering
an
electroactive
mechanical
nanoreinforcer
capable
converting
nonconductive
scaffolds
excellent
conductors
electricity
with
impressive
effect
on
properties
for
organs
tissues
such
cardiac,
skeletal
muscle,
nerve.
However,
many
questions
problems
remain
unresolved
that
need
be
answered
usher
these
materials
toward
true
destiny.
Thus,
this
review
paper
aims
provide
overview
design
applications
MXene‐integrated
composites
applications,
cardiac
tissue
engineering,
wound
healing,
infection
therapy,
cancer
biosensors.
Moreover,
current
challenges
limitations
utilizing
vivo
are
highlighted
discussed,
followed
by
its
prospects
guideline
possible
various
futuristic
applications.
This
article
will
inspire
researchers,
who
search
opportunities,
using
nanomaterial
Advanced Science,
Journal Year:
2021,
Volume and Issue:
9(2)
Published: Nov. 19, 2021
Cancer
is
one
of
the
top
life-threatening
dangers
to
human
survival,
accounting
for
over
10
million
deaths
per
year.
Bioactive
glasses
have
developed
dramatically
since
their
discovery
50
years
ago,
with
applications
that
include
therapeutics
as
well
diagnostics.
A
new
system
within
bioactive
glass
family,
mesoporous
(MBGs),
has
evolved
into
a
multifunctional
platform,
thanks
MBGs
easy-to-functionalize
nature
and
tailorable
textural
properties-surface
area,
pore
size,
volume.
Although
yet
meet
potential
in
tumor
treatment
imaging
practice,
recently
research
shed
light
on
distinguished
capabilities
promising
theranostic
systems
cancer
therapy.
This
review
presents
progress
field
MBG
diagnosis
therapy,
including
synthesis
MBGs,
mechanistic
overview
application
drug
monitoring,
therapy
(
particularly,
targeted
delivery
stimuli-responsive
nanoplatforms),
immunological
profile
MBG-based
nanodevices
reference
development
novel
therapeutics.
Cancer Cell International,
Journal Year:
2021,
Volume and Issue:
21(1)
Published: April 1, 2021
Abstract
Cancer
is
a
complex
disease
orchestrated
by
various
extrinsic
and
intrinsic
pathways.
In
recent
years,
there
has
been
keen
interest
towards
the
development
of
natural
extracts-based
cancer
therapeutics
with
minimum
adverse
effects.
pursuit
effective
strategy,
wide
variety
products-derived
compounds
have
addressed
for
their
anticancer
Apigenin
naturally-occurring
flavonoid
present
abundantly
in
fruits
vegetables.
Decades
research
delineated
pharmacological
biological
properties
apigenin.
Specifically,
apigenin-mediated
activities
documented
types
cancer,
but
generalized
scientific
evidence
encompassing
molecular
interactions
processes,
such
as
regulation
apoptotic
machinery,
aberrant
cell
signaling
oncogenic
protein
network
not
comprehensively
covered.
this
sense,
review
we
attempted
to
focus
on
pathways
cancers.
We
also
cutting-edge
which
unveiled
remarkable
abilities
apigenin
interact
microRNAs
modulate
key
cellular
special
emphasis
nano-formulations
that
can
help
targeted
delivery
be
therapeutic
solution
treatment
International Journal of Applied Glass Science,
Journal Year:
2022,
Volume and Issue:
14(1), P. 69 - 87
Published: Aug. 3, 2022
Abstract
There
is
an
ongoing
profound
shift
in
using
glass
as
a
primarily
passive
material
to
one
that
instills
active
properties.
We
believe
and
demonstrate
bioactive
glasses
(BGs)
glass–ceramics
(BGCs)
functional
biomaterials
for
cancer
therapy
can
transform
the
world
of
healthcare
21st
century.
Melt/gel‐derived
BGs
BGCs
carry
many
exotic
elements,
including
less
common
rare‐earth,
trigger
highly
efficient
anticancer
properties
via
combination
radiotherapy,
photothermal
therapy,
magnetic
hyperthermia,
along
with
drug
or
therapeutic
ions
delivery.
The
addition
these
dopants
modifies
bioactivity,
imparts
novel
functionalities,
induces
specific
biological
effects
are
not
achievable
other
classes
biomaterials.
In
this
paper,
we
have
briefly
reviewed
discussed
current
knowledge
on
promising
compositions,
processing
parameters,
applications
treating
cancer.
also
envisage
need
further
research
particular,
unique
class
BGCs.
Pharmaceutics,
Journal Year:
2022,
Volume and Issue:
14(6), P. 1160 - 1160
Published: May 29, 2022
Apigenin
(Ap)
is
one
of
the
most
important
natural
flavonoids
that
has
potent
anticancer
activity.
This
study
was
designed,
for
first
time,
to
load
Ap
into
chitosan
improve
its
hydrophobicity
and
then
it
coated
with
albumin-folic
acid
increase
stability
bioavailability
target
cancer
cells.
The
newly
developed
encapsulated
(Ap-CH-BSA-FANPs)
characterized
tested
in
vitro.
zeta
potential
-17.0
mV
within
recommended
range
(-30
+30
mV),
indicating
apigenin
would
not
quickly
settle
be
suspended.
vitro
results
proved
great
activity
on
HePG-2
cells
compared
pure
Ap.
treated
Ap-CH-BSA-FANPs
demonstrated
induction
apoptosis
by
increasing
p53
gene
expression,
arresting
cell
cycle,
caspase-9
levels,
decreasing
both
MMP9
Bcl-2
protein
expression
levels.
Moreover,
higher
antioxidant
treatment
evident
through
SOD
levels
CAT
concentration.
In
conclusion,
were
easy
produce
low
coast,
continued
drug
release,
good
loading
capacity,
high
solubility
physiological
pH,
more
stable
than
formerly
Ap-loaded
liposomes
or
PLGA.
may
a
promising
chemotherapeutic
agent
HCC.
