NLRP3 inflammasome and IL-1β pathway in type 2 diabetes and atherosclerosis: Friend or foe?

Pharmacological Research, Journal Year: 2021, Volume and Issue: 173, P. 105885 - 105885

Published: Sept. 16, 2021

Language: Английский

---

MCC950 in the treatment of NLRP3-mediated inflammatory diseases: Latest evidence and therapeutic outcomes

International Immunopharmacology, Journal Year: 2022, Volume and Issue: 106, P. 108595 - 108595

Published: Feb. 3, 2022

Language: Английский

---

Scaffold Hybrid of the Natural Product Tanshinone I with Piperidine for the Discovery of a Potent NLRP3 Inflammasome Inhibitor

Journal of Medicinal Chemistry, Journal Year: 2023, Volume and Issue: 66(4), P. 2946 - 2963

Published: Feb. 14, 2023

Natural products provide inspiration and have proven to be the most valuable source for drug discovery. Herein, we report a scaffold hybrid strategy of Tanshinone I discovery NLRP3 inflammasome inhibitors. 36 compounds were designed synthesized, cheminformatic analyses showed that these occupy unique chemical space. The biological evaluation identified 5j, 12a, 12d as inhibitors with significant potency, selectivity, drug-likeness. Mechanistic studies revealed derivatives could inhibit degradation protein block oligomerization NLRP3-induced apoptosis-associated speck-like proteins, thus inhibiting activation. In addition, water solubility, in vitro metabolic stability, oral bioavailability also greatly improved compared I. Therefore, this protocol provides new structural evolution class potent

Language: Английский

---

Astragaloside IV alleviates PM2.5-caused lung toxicity by inhibiting inflammasome‐mediated pyroptosis via NLRP3/caspase-1 axis inhibition in mice

Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 150, P. 112978 - 112978

Published: April 22, 2022

Exposure to particulate matter (PM)2.5 in air pollution is a serious health issue worldwide. At present, effective prevention measures and modalities of treatment for PM2.5-caused lung toxicity are lacking. This study elucidated the protective effect astragaloside IV (Ast), natural product from Astragalus membranaceous Bunge, against its possible molecular mechanisms. The mice model was performed by intratracheal instillation PM2.5 dust suspension. investigation with Ast or combination nigericin, which NOD-like receptor protein 3 (NLRP3) activator. results revealed that lead significant inflammation promoted pyroptosis pattern cell death upregulating pro-inflammatory cytokines causing oxidative stress related NLRP3 inflammasome-mediated pathway. protected resulted via suppressing NLRP3/caspase-1 axis inhibition, thereby protecting PM2.5-induced damage, eventually resulting prolonged survival mice. Nigericin partially reversed effects Ast. present research provides new insights into therapeutic potential Ast, demonstrating it might be candidate respiratory diseases. Targeting inflammasome novel tactic

Language: Английский

---

Matrine suppresses NLRP3 inflammasome activation via regulating PTPN2/JNK/SREBP2 pathway in sepsis

Phytomedicine, Journal Year: 2022, Volume and Issue: 109, P. 154574 - 154574

Published: Nov. 21, 2022

Language: Английский

---

A review on the medicinal applications of flavonoids from aloe species

European Journal of Medicinal Chemistry Reports, Journal Year: 2024, Volume and Issue: 10, P. 100135 - 100135

Published: Feb. 15, 2024

The literature has examined the therapeutic properties of flavonoids found in Aloe species. According to reports, extracts exhibited antioxidant like genistein, isovitexin, isorhamnetin, and daidzenin. It been reported that A. vera, arborescens, grandidentata, perfoliata, brevifolia, saponaria all displayed anti-inflammatory such as vicenin 2, lucenin orientin, isovitexin. species have antimicrobial qualities prevent or stop growth germs due diverse range chemicals they contain. hijazensis had antifungal literature. biological antioxidant, anti-inflammatory, antimicrobial, anti-aging properties, are employed treatment prevention chronic diseases diabetes, cancer, COVID-19, others. Flavonoids derived from genus commonly utilized pharmaceutical, nutraceutical, cosmeceutical products for their medicinal potentials. Many proving effects; however, species, which shown still being thoroughly compiled. Thus, current objective is provide a comprehensive overview structures, categories, analyses present medicinally useful

Language: Английский

---

The potential anti-Alzheimer's activity of Oxalis corniculata Linn. Methanolic extract in experimental rats: Role of APOE4/LRP1, TLR4/NF-κβ/NLRP3, Wnt 3/β-catenin/GSK-3β, autophagy and apoptotic cues

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 324, P. 117731 - 117731

Published: Jan. 11, 2024

Oxalis corniculata (O. corniculata) is a member of Oxalidaceae family, widely distributed in Asia, Europe, America, and Africa, used extensively as food its traditional folkloric uses include management epilepsy, gastric disorders, neurodegenerative diseases, together with use enhancing health. Numerous pharmacological benefits O. are linked to anti-inflammatory antioxidant abilities. One the most prevalent disorders Alzheimer's disease (AD) which neuroinflammation oxidative stress main pathogenic processes. Our research aimed study neuroprotective effect methanolic extract Linn. ME), compared selenium (Se) against AlCl3-induced AD. Forty male albino rats were allocated into four groups (Gps). Gp I control group, rest animals received AlCl3 (Gp II-Gp IV). Rats III IV treated Se ME, respectively. The chemical profile ME was studied using ultraperformance liquid chromatography-electrospray ionization-quadrupole time-of-flight mass spectrometry, allowing tentative identification sixty-six compounds, including organic acids, phenolics others, cinnamic acid derivatives, fatty flavonoids. showed deterioration short-term memory brain histological pictures. findings that helped combat produced by accumulation prophylaxis Thus, Selenium restored defense, via Nrf2/HO-1 hub, hampered neuroinflammation, TLR4/NF-κβ/NLRP3, along dampening apoptosis, Aβ generation, tau hyperphosphorylation, BACE1, ApoE4 LRP1 levels. Treatments also promoted autophagy modulated Wnt 3/β-catenin/GSK3β cue. It noted notable ameliorative on Nrf2/HO-1, APOE4/LRP1, 3/β-catenin/GSK-3β PERK axes.

Language: Английский

---

The Protective Effects of Vanillic Acid on LPS-induced Acute Lung Injury by Inhibiting STIM1-mediated NLRP3 Inflammasome Activation

Inflammation, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Acute lung injury (ALI), which can progress to acute respiratory distress syndrome (ARDS), has inflammation as a crucial factor, especially the NOD-like receptor thermal protein domain associated 3 (NLRP3) inflammasome involvement. Stromal interaction molecule 1 (STIM1) block NLRP3 activation, but mechanism is unclear. Vanillic acid, possessing anti-inflammatory properties, role in (ALI) whose specific remains This study aimed investigate effectiveness of vanillic acid ALI induced by lipopolysaccharides (LPS) and elucidate potential mechanisms. In vitro vivo experiments were conducted using cells mouse model find out impact underlying We found that demonstrated significant inhibition IL-1β IL-18 release triggered LPS nigericin J774A.1 cells. The findings indicated not only mitigated also suppressed activation mice. Mechanistically, inhibited LPS-induced increase STIM1 expression through lysosomal degradation pathway. reduced diminished intracellular Ca2+ levels, thereby suppressing impeding cleavage maturation Caspase-1 GSDMD, eventually attenuating cell pyroptosis. exerts its inhibitory effects on promoting degradation, ameliorates NLRP3-GSDMD mediated STIM1-NLRP3 signaling axis represents promising avenue for therapeutic interventions ALI.

Language: Английский

---

Regulation and therapeutic potential of NLRP3 inflammasome in intestinal diseases

Journal of Leukocyte Biology, Journal Year: 2025, Volume and Issue: 117(4)

Published: April 1, 2025

Abstract The NOD-like receptor family, particularly the protein 3 that contains pyrin domain (NLRP3), is an intracellular sensing complex responsible for detecting patterns associated with pathogens and injuries. NLRP3 plays a crucial role in innate immune response. Currently, wide range of research has indicated importance various inflammatory conditions. Similarly, inflammasome significant preserving intestinal balance impacting advancement diseases. In addition, several randomized trials have demonstrated safety efficacy targeting treatment colitis, colorectal cancer, related This review explores mechanisms assembly activation gut. We describe its pathological significance Finally, we summarize current future therapeutic approaches

Language: Английский

---

Recent advances in the effects of dietary polyphenols on inflammation in vivo: potential molecular mechanisms, receptor targets, safety issues, and uses of nanodelivery system and polyphenol polymers

Current Opinion in Food Science, Journal Year: 2022, Volume and Issue: 48, P. 100921 - 100921

Published: Sept. 5, 2022

Language: Английский

---