Journal of Agricultural and Food Chemistry,
Journal Year:
2022,
Volume and Issue:
70(47), P. 14864 - 14876
Published: Nov. 15, 2022
Gut
dysbiosis
and
bile
acid
(BA)
metabolism
disturbance
are
involved
in
the
pathogenesis
of
ulcerative
colitis.
This
study
aimed
to
investigate
effect
fucoidan
on
BA
gut
microbiota
dextran
sulfate
sodium-induced
colitis
mice.
Our
results
showed
that
effectively
suppressed
colonic
inflammation
repaired
barrier.
In
addition,
increased
relative
abundance
Lachnospiraceae
family,
such
as
Turicibacter,
Muribaculum,
Parasutterella,
Colidextribacter,
followed
by
an
increase
short-chain
fatty
acids,
especially
butyrate.
Moreover,
modulated
elevating
cholic
acid,
ursodeoxycholic
deoxycholic
lithocholic
decreasing
β-muricholic
which
led
activation
FXR
TGR5
further
enhanced
barrier
inflammation.
revealed
alleviating
was
largely
mediated
microbiota,
confirmed
fecal
transplantation
experiment.
Collectively,
these
findings
provided
basis
for
a
potential
functional
food
Cell Death Discovery,
Journal Year:
2023,
Volume and Issue:
9(1)
Published: Sept. 29, 2023
Abstract
Inflammatory
Bowel
Disease
(IBD),
a
chronic
nonspecific
intestinal
inflammatory
disease,
is
comprised
of
Ulcerative
Colitis
(UC)
and
Crohn’s
(CD).
IBD
closely
related
to
systemic
reaction
affects
the
progression
many
extraintestinal
diseases.
As
one
representative
bacteria
for
probiotic-assisted
therapy
in
IBD,
multiple
strains
Lactobacillus
have
been
proven
alleviate
damage
strengthen
immunological
barrier,
epithelial
cell
mucus
barrier.
also
spares
no
effort
alleviation
IBD-related
diseases
such
as
Colitis-associated
Colorectal
cancer
(CAC),
Alzheimer’s
(AD),
Depression,
Anxiety,
Autoimmune
Hepatitis
(AIH),
so
on
via
gut-brain
axis
gut-liver
axis.
This
article
aims
discuss
role
diseases,
including
its
underlying
mechanisms
curative
strategies
from
present
future.
Cells,
Journal Year:
2023,
Volume and Issue:
12(14), P. 1888 - 1888
Published: July 19, 2023
The
intestinal
barrier
is
a
precisely
regulated
semi-permeable
physiological
structure
that
absorbs
nutrients
and
protects
the
internal
environment
from
infiltration
of
pathological
molecules
microorganisms.
Bile
acids
are
small
synthesized
cholesterol
in
liver,
secreted
into
duodenum,
transformed
to
secondary
or
tertiary
bile
by
gut
microbiota.
interact
with
acid
receptors
(BARs)
microbiota,
which
plays
key
role
maintaining
homeostasis
barrier.
In
this
review,
we
summarize
discuss
recent
studies
on
disorder
associated
dysfunction
related
diseases.
We
focus
roles
acids,
BARs,
microbiota
triggering
dysfunction.
Insights
for
future
prevention
treatment
diseases
provided.
Advances in Nutrition,
Journal Year:
2025,
Volume and Issue:
unknown, P. 100376 - 100376
Published: Jan. 1, 2025
Aging
is
associated
with
the
decline
of
tissue
and
cellular
functions,
which
can
promote
development
age-related
diseases
like
cancer,
cardiovascular
disease,
neurodegeneration,
disorders
musculoskeletal
immune
systems.
Healthspan
length
time
an
individual
in
good
health
free
from
chronic
disabilities
aging.
Two
modifiable
factors
that
influence
healthspan,
healthy
aging,
prevent
diseases,
are
diet
microbiota
gastrointestinal
tract
(gut
microbiota).
This
review
will
discuss
how
dietary
phytochemicals
gut
work
concert
to
a
First
overview
provided
influences
aging
through
its
impact
on
barrier
integrity,
function,
mitochondria
function
oxidative
stress.
Next,
mechanisms
by
effect
health,
inflammation,
nurture
diverse
microbial
composition
discussed.
Lastly,
directly
producing
bioactive
metabolites
food
urolithin
A,
equol,
hesperetin
sulforaphane.
These
other
phytochemical
derived
may
healthspan
Importantly,
individual's
capacity
produce
promoting
cruciferous
vegetables,
berries,
nuts,
citrus
soy
products
be
dependent
specific
bacteria
present
gut.
Microbiome,
Journal Year:
2025,
Volume and Issue:
13(1)
Published: Feb. 4, 2025
Disorder
in
bile
acid
(BA)
metabolism
is
known
to
be
an
important
factor
contributing
diarrhea.
However,
the
pathogenesis
of
BA
disorder-induced
diarrhea
remains
unclear.
The
colonic
pool
and
microbiota
between
health
piglets
diarrheal
were
compared.
Fecal
transplantation
various
cell
experiments
further
indicated
that
chenodeoxycholic
(CDCA)
metabolic
disorder
produced
CDCA-3β-glucuronide,
which
main
cause
Non-targeted
metabolomics
uncovered
inhibition
glucuronidation
by
Lactobacillus
reuteri
(L.
reuteri)
through
deriving
indole-3-carbinol
(I3C).
In
vitro,
gene
involved
reduction
induced-diarrhea
screened
RNA
transcriptomics
sequencing,
activation
pathway
FXR-SIRT1-LKB1
alleviate
P53-mediated
apoptosis
proposed
vitro
multifarious
siRNA
interference,
CO-IP,
immunofluorescence,
so
on,
mechanism
was
also
verified
a
variety
mouse
models.
Here,
we
reveal
for
first
time
core
derived
I3C
represses
gut
epithelium
glucuronidation,
particularly
3β-glucuronic
CDCA
production,
reaction
mediated
host
UDP
glucuronosyltransferase
family
1
member
A4
(UGT1A4)
necessary
induced
Mechanistically,
L.
activates
aryl
hydrocarbon
receptor
decrease
UGT1A4
transcription
CDCA-3β-glucuronide
content,
thereby
upregulating
signal.
LKB1
binds
with
P53
based
on
protein
interaction,
ultimately
resists
Moreover,
assists
attain
ameliorative
effects
FXR
diarrhea,
reversion
abnormal
pathway,
improving
outcomes
supplement.
These
findings
uncover
crucial
interplay
epithelial
cells
microbes,
highlighting
UGT1A4-mediated
conversion
as
key
target
ameliorating
Oxidative Medicine and Cellular Longevity,
Journal Year:
2021,
Volume and Issue:
2021(1)
Published: Jan. 1, 2021
Antioxidant
polyphenols
from
plants
are
potential
dietary
supplementation
to
alleviate
early
weaning‐induced
intestinal
disorders
in
piglets.
Recent
evidences
showed
polyphenol
quercetin
could
reshape
gut
microbiota
when
it
functioned
as
anti‐inflammation
or
antioxidation
agents
rodent
models.
However,
the
effect
of
on
and
weanling
piglets,
along
with
role
this
effect,
both
remain
unclear.
Here,
we
determined
quercetin’s
attenuating
diarrhea,
damage,
redox
imbalance,
well
by
transferring
quercetin‐treated
fecal
recipient
The
results
that
decreased
piglets’
scores
improved
damage
increasing
tight
junction
protein
occludin,
villus
height,
height/crypt
depth
ratio
but
crypt
epithelial
apoptosis
(TUNEL
staining).
Quercetin
also
increased
antioxidant
capacity
indices,
including
total
capacity,
catalase,
glutathione/oxidized
glutathione
disulfide
oxidative
metabolite
malondialdehyde
jejunum
tissue.
Fecal
transplantation
(FMT)
piglets
had
comparable
effects
improving
antioxidative
than
supplementation.
Further
analysis
using
16S
rDNA
sequencing
FMT
shifted
structure
diversity
microbiota.
Especially,
anaerobic
trait
carbohydrate
metabolism
functions
were
enriched
after
FMT,
which
may
owe
intestine.
relative
abundances
Fibrobacteres,
Akkermansia
muciniphila
,
Clostridium
butyricum
celatum
Prevotella
copri
Proteobacteria,
Lactobacillus
coleohominis
Ruminococcus
bromii
.
Besides,
quercetin‐shifted
bacteria
metabolites
short
chain
fatty
acids
significantly
related
indices
integrity.
Overall,
attenuated
diarrhea
enhancing
regulating
microbial
Computational and Structural Biotechnology Journal,
Journal Year:
2022,
Volume and Issue:
20, P. 2402 - 2414
Published: Jan. 1, 2022
Inflammatory
bowel
disease
(IBD),
comprising
Crohn’s
(CD)
and
ulcerative
colitis
(UC),
is
a
set
of
clinically
chronic,
relapsing
gastrointestinal
inflammatory
lacks
an
absolute
cure.
Although
the
precise
etiology
unknown,
developments
in
high-throughput
microbial
genomic
sequencing
significantly
illuminate
changes
intestinal
structure
functions
patients
with
IBD.
The
application
metabolomics
suggests
that
microbiota
can
influence
IBD
pathogenesis
by
producing
metabolites,
which
are
implicated
as
crucial
mediators
host-microbial
crosstalk.
This
review
aims
to
elaborate
current
knowledge
perturbations
microbiome–metabolome
interface
description
altered
composition
metabolite
profiles
gut
microbiota.
We
emphasized
elaborated
recent
findings
several
potentially
protective
classes
IBD,
including
fatty
acids,
amino
acids
derivatives
bile
acids.
article
will
facilitate
deeper
understanding
new
therapeutic
approach
for
applying
metabolome-based
adjunctive
treatment.
Antioxidants,
Journal Year:
2023,
Volume and Issue:
12(1), P. 200 - 200
Published: Jan. 15, 2023
Dihydromyricetin
(DHY),
the
main
flavonoid
component
in
Ampelopsis
grossedentata,
has
important
benefits
for
health.
The
present
study
aimed
to
investigate
exact
effects
and
possible
mechanisms
of
DHY
on
diabetic
cardiomyopathy
(DCM).
Male
C57BL/6
mice
sirtuin
3
(SIRT3)
knockout
(SIRT3-KO)
were
injected
with
streptozotocin
(STZ)
induce
a
model.
Two
weeks
later,
(250
mg/kg)
or
carboxymethylcellulose
(CMC)
administrated
once
daily
by
gavage
twelve
weeks.
We
found
that
alleviated
fasting
blood
glucose
(FBG)
triglyceride
(TG)
as
well
glycosylated
hemoglobin
(HbA1c)
levels;
increased
insulin
(FINS);
improved
cardiac
dysfunction;
ameliorated
myocardial
hypertrophy,
fibrosis
injury;
suppressed
oxidative
stress,
inflammasome
necroptosis;
but
SIRT3
expression
STZ-induced
mice.
Neonatal
rat
cardiomyocytes
pre-treated
(80
μM)
without
high
(HG)
stimulation.
results
showed
attenuated
cell
damage
inhibited
necroptosis
Moreover,
above
protective
DCM
unavailable
SIRT3-KO
mice,
implying
promising
medical
potential
treatment.
In
sum,
inflammation
via
activation
suggesting
may
serve
candidate
an
agent
attenuate
cardiomyopathy.
