Elsevier eBooks, Journal Year: 2023, Volume and Issue: unknown, P. 367 - 377
Published: Jan. 1, 2023
Language: Английский
Nutrients, Journal Year: 2022, Volume and Issue: 14(21), P. 4637 - 4637
Published: Nov. 3, 2022
Nutraceuticals are the nourishing components (hybrid of nutrition and pharmaceuticals) that biologically active possess capability for maintaining optimal health benefits. These products play a significant role in human care its endurance, most importantly future therapeutic development. have received recognition due to their nutritional benefits along with effects safety profile. globally growing field services such as promotion, disease reduction, etc. Various drug nutraceutical interactions also been elaborated various examples this review. Several patents on nutraceuticals agricultural applications diseases stated last section review, which confirms exponential growth nutraceuticals’ market value. used not only but support therapy prevention treatment diseases, reduce side cancer chemotherapy radiotherapy. Diverse novel nanoformulation approaches tend overcome challenges involved formulation development nutraceuticals. Prior information drugs may help preventing any deleterious products. Nanotechnology leads generation micronized dietary other supplements improved In review article, latest key findings (clinical studies) show action nutraceutical’s bioactive molecules discussed.
Language: Английский
Citations
149
Separations, Journal Year: 2023, Volume and Issue: 10(3), P. 177 - 177
Published: March 6, 2023
Herbal nutraceuticals are foods derived from plants and/or their derivatives, such as oils, roots, seeds, berries, or flowers, that support wellness and combat acute chronic ailments induced by unhealthful dietary habits. The current review enlists various traditional well unexplored herbs including angelica, burnet, caraway, laurel, parsley, yarrow, zedoary, which rich sources of bioactive components, aloesin, angelicin, trans-anethole, cholesteric-7-en-3β-ol. further compares some the extraction purification techniques, namely, Soxhlet extraction, ultrasound assisted microwave supercritical fluid accelerated solvent hydro-distillation ultra-high-pressure enzyme pulsed electric field bio affinity chromatography, cell membrane ligand fishing. can be purchased in varied formulations, capsules, pills, powders, liquids, gels. Some formulations currently available on market discussed here. Further, significance herbal prevention cure diseases, diabetes, obesity, dementia, hypertension, hypercholesterolemia; immunomodulators antimicrobial agents has been discussed. Noteworthy, inappropriate use these lead to hepatotoxicity, pulmonary toxicity, cytotoxicity, carcinogenicity, nephrotoxicity, hematotoxicity, cardiac toxicity. Hence, this concludes with a discussion regulatory aspects undertaken government agencies order minimize adverse effects associated nutraceuticals.
Language: Английский
Citations
42
GSC Advanced Research and Reviews, Journal Year: 2024, Volume and Issue: 18(3), P. 083 - 090
Published: March 9, 2024
The regulation of herbal medicine in Nigeria stands at the intersection tradition and modernity, presenting a complex landscape shaped by historical practices, cultural beliefs, contemporary healthcare standards. This paper delves into intricate dynamics surrounding Nigeria, aiming to elucidate challenges opportunities inherent balancing traditional practices with modern regulatory Drawing from multidisciplinary approach encompassing medical anthropology, public health, legal studies, this research explores roots tracing its evolution indigenous healing current status within broader system. It examines significance medicine, considering role local communities enduring relevance addressing needs, particularly underserved rural areas. However, alongside rich tapestry healing, concerns regarding safety, efficacy, standardization have prompted calls for reforms align scrutinizes existing frameworks governing analyzing strengths, weaknesses, gaps therein. tension between preserving knowledge ensuring consumer protection, highlighting need nuanced that respects heritage while safeguarding health. Furthermore, assesses implications interventions on various stakeholders, including practitioners, consumers, policymakers. considers strategies enhancing collaboration healers formal sector, fostering mutual respect, promoting evidence-based practices. Ultimately, study underscores imperative striking delicate balance modernity regulating advocating harmonized upholds both integrity quality.
Language: Английский
Citations
24
Molecules, Journal Year: 2022, Volume and Issue: 28(1), P. 240 - 240
Published: Dec. 28, 2022
Vitamin B12, also known as the anti-pernicious anemia factor, is an essential micronutrient totally dependent on dietary sources that commonly integrated with food supplements. Four vitamin B12 forms—cyanocobalamin, hydroxocobalamin, 5′-deoxyadenosylcobalamin, and methylcobalamin—are currently used for supplementation and, here, we provide overview of their biochemical role, bioavailability, efficacy in different dosage forms. Since effective quantity depends stability forms, further a review main reactivity under exposure to various environmental factors (e.g., temperature, pH, light) presence some typical interacting compounds (oxidants, reductants, other water-soluble vitamins). Further, explore how manufacturing process storage affect foods, supplements, medicines summary data published date content-related quality products market. We approaches toward stabilization, including minimization destabilizing factors, addition proper stabilizers, or application (innovative) technological processes could be implemented contribute production high-quality products.
Language: Английский
Citations
50
Brain Sciences, Journal Year: 2023, Volume and Issue: 13(9), P. 1305 - 1305
Published: Sept. 11, 2023
Epilepsy is a complex neurological disorder affecting millions worldwide, with substantial number of patients facing drug-resistant epilepsy. This comprehensive review explores innovative therapies for epilepsy management, focusing on their principles, clinical evidence, and potential applications. Traditional antiseizure medications (ASMs) form the cornerstone treatment, but limitations necessitate alternative approaches. The delves into cutting-edge such as responsive neurostimulation (RNS), vagus nerve stimulation (VNS), deep brain (DBS), highlighting mechanisms action promising outcomes. Additionally, gene optogenetics in research discussed, revealing groundbreaking findings that shed light seizure mechanisms. Insights cannabidiol (CBD) ketogenic diet adjunctive further broaden spectrum management. Challenges achieving control traditional therapies, including treatment resistance individual variability, are addressed. importance staying updated emerging trends management emphasized, along hope improved therapeutic options. Future directions, combining AI applications, non-invasive optogenetics, hold promise personalized effective treatment. As field advances, collaboration among researchers natural synthetic biochemistry, clinicians from different streams various forms medicine, will drive progress toward better higher quality life individuals living
Language: Английский
Citations
35
Separation and Purification Technology, Journal Year: 2023, Volume and Issue: 320, P. 124018 - 124018
Published: May 9, 2023
Language: Английский
Citations
26
Sustainable Food Technology, Journal Year: 2024, Volume and Issue: 2(5), P. 1428 - 1455
Published: Jan. 1, 2024
Recent research has focused on using plant-based polysaccharides, proteins, and lipids to create functional films coatings with desirable properties.
Language: Английский
Citations
15
Foods, Journal Year: 2024, Volume and Issue: 13(2), P. 352 - 352
Published: Jan. 22, 2024
Microalgae are a sustainable source for the production of biofuels and bioactive compounds. This review discusses significant research on innovative extraction techniques using dimethyl ether (DME) as green subcritical fluid. DME, which is characterized by its low boiling point safety an organic solvent, exhibits remarkable properties that enable high rates various active compounds, including lipids from high-water-content microalgae without need drying. In this review, superiority liquefied DME technology over conventional methods discussed in detail. addition, we elucidate mechanism address human health environment. also covers aspects related to equipment, applications different processes, estimation trend analysis Hansen solubility parameters. anticipate promising trajectory expansion resources.
Language: Английский
Citations
12
Phytotherapy Research, Journal Year: 2024, Volume and Issue: 38(5), P. 2361 - 2387
Published: March 1, 2024
Abstract As the global population ages, preventing lifestyle‐ and aging‐related diseases is increasing, necessitating search for safe affordable therapeutic interventions. Among nutraceuticals, quercetin, a flavonoid ubiquitously present in various plants, has garnered considerable interest. This review aimed to collate analyze existing literature on potentials of especially its interactions with SIRTs clinical applicability based bioavailability safety. narrative was survey spanning from 2015 2023 using PUBMED. The keywords MeSH terms used were: “quercetin” AND “bioavailability” OR “metabolism” “metabolites” as well “SIRTuin” “SIRT*” “cellular effects” “pathway” “signaling” “neuroprotective” “cardioprotective” “nephroprotective” “antiatherosclerosis” “diabetes” “antidiabetic” “dyslipidemia” “mice” “rats”. Quercetin demonstrates multiple activities, including neuroprotective, cardioprotective, anti‐atherosclerotic effects. Its antioxidant, anti‐inflammatory, antiviral, immunomodulatory properties are well‐established. At molecular level, it majorly interacts SIRTs, particularly SIRT1 SIRT6, modulates numerous signaling pathways, contributing These pathways play roles reducing oxidative stress, inflammation, autophagy regulation, mitochondrial biogenesis, glucose utilization, fatty acid oxidation, genome stability. However, trials quercetin's effectiveness humans scarce. exhibits wide range SIRT‐mediated Despite compelling preclinical data, more standardized needed fully understand potential. Future research should focus addressing safety concerns.
Language: Английский
Citations
10
Foods, Journal Year: 2024, Volume and Issue: 13(15), P. 2441 - 2441
Published: Aug. 2, 2024
Aging is a natural and irreversible process, affecting living organisms by negatively impacting the tissues' cells' morphology functionality consequently being responsible for aging-related diseases. Taking into account actual preoccupations of both consumers researchers, healthy anti-aging alternatives are intensively studied in order to address such concerns. Due their functional features, plant flavonoids can be considered valuable nutraceuticals. This paper highlights possibilities use extracted from various plants potential on skin, brain, heart. Moreover, anticarcinogenic, anti-inflammatory, anti-diabetic properties summarized, along with senescence-associated mechanisms. Both nutraceutical cosmeceutical fields continuously developing originating promising candidates obtain products. Thus, bioactive compounds' extraction subsequent involvement innovative product manufacturing must carefully performed while aware intrinsic extrinsic factors that may affect phytochemicals' structures, bioavailability, health effects.
Language: Английский
Citations
10