Polystyrene microplastics affect learning and memory in mice by inducing oxidative stress and decreasing the level of acetylcholine

Food and Chemical Toxicology, Journal Year: 2022, Volume and Issue: 162, P. 112904 - 112904

Published: March 4, 2022

Language: Английский

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TREM2 activation alleviates neural damage via Akt/CREB/BDNF signalling after traumatic brain injury in mice

Journal of Neuroinflammation, Journal Year: 2022, Volume and Issue: 19(1)

Published: Dec. 3, 2022

Neuroinflammation is one of the most important processes in secondary injury after traumatic brain (TBI). Triggering receptor expressed on myeloid cells 2 (TREM2) has been proven to exert neuroprotective effects neurodegenerative diseases and stroke by modulating neuroinflammation, promoting phagocytosis cell survival. However, role TREM2 TBI not yet elucidated. In this study, we are first use COG1410, an agonist TREM2, assess activation a murine model.

Language: Английский

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The Role of BDNF as a Biomarker in Cognitive and Sensory Neurodegeneration

Journal of Personalized Medicine, Journal Year: 2023, Volume and Issue: 13(4), P. 652 - 652

Published: April 10, 2023

Brain-derived neurotrophic factor (BDNF) has a crucial function in the central nervous system and sensory structures including olfactory auditory systems. Many studies have highlighted protective effects of BDNF brain, showing how it can promote neuronal growth survival modulate synaptic plasticity. On other hand, conflicting data about expression functions cochlear been reported. Several clinical experimental research showed alterations levels neurodegenerative diseases affecting peripheral system, suggesting that be promising biomarker most conditions, Alzheimer’s disease, shearing loss, or impairment. Here, we summarize current concerning brain domains (olfaction hearing), focusing on BDNF/TrkB signalling pathway activation both physiological pathological conditions. Finally, review significant highlighting possibility to target as early diagnosis cognitive neurodegeneration, opening new opportunities develop effective therapeutic strategies aimed counteract neurodegeneration.

Language: Английский

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PI3K/AKT signaling pathway: Molecular mechanisms and therapeutic potential in depression

Pharmacological Research, Journal Year: 2024, Volume and Issue: 206, P. 107300 - 107300

Published: July 9, 2024

Depression is a serious global mental disorder. Numerous studies have found that depression may be closely related to decreased neurogenesis, neuroinflammation, neurotransmitter imbalance, and synaptic plasticity dysfunction. The pathogenesis of complex involves multiple signal transduction pathways molecular changes. PI3K/AKT pathway an essential signaling in neurons, which widely expressed emotion-related regions the brain. Therefore, play moderating role mood disorders. However, mechanism not been fully described. This review systematically summarized discussed its potential treatment depression. will help development antidepressants.

Language: Английский

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Prebiotics modulate the microbiota–gut–brain axis and ameliorate anxiety and depression-like behavior in HFD-fed mice

Food Research International, Journal Year: 2024, Volume and Issue: 182, P. 114153 - 114153

Published: Feb. 23, 2024

Language: Английский

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The pivotal role of JAK/STAT and IRS/PI3K signaling pathways in neurodegenerative diseases: Mechanistic approaches to polyphenols and alkaloids

Phytomedicine, Journal Year: 2023, Volume and Issue: 112, P. 154686 - 154686

Published: Jan. 31, 2023

Language: Английский

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The Molecular Pathway of p75 Neurotrophin Receptor (p75NTR) in Parkinson’s Disease: The Way of New Inroads

Molecular Neurobiology, Journal Year: 2023, Volume and Issue: 61(5), P. 2469 - 2480

Published: Oct. 28, 2023

Language: Английский

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Advances in Material‐Assisted Electromagnetic Neural Stimulation

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(26)

Published: April 10, 2024

Bioelectricity plays a crucial role in organisms, being closely connected to neural activity and physiological processes. Disruptions the nervous system can lead chaotic ionic currents at injured site, causing disturbances local cellular microenvironment, impairing biological pathways, resulting loss of functions. Electromagnetic stimulation has ability generate internal currents, which be utilized counter tissue damage aid restoration movement paralyzed limbs. By incorporating implanted materials, electromagnetic targeted more accurately, thereby significantly improving effectiveness safety such interventions. Currently, there have been significant advancements development numerous promising strategies with diverse materials. This review provides comprehensive summary fundamental theories, modulating material application strategies, pre-clinical therapeutic effects associated for repair. It offers thorough analysis current techniques that employ materials enhance stimulation, as well potential future applications.

Language: Английский

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Mini-encyclopedia of mitochondria-relevant nutraceuticals protecting health in primary and secondary care—clinically relevant 3PM innovation

The EPMA Journal, Journal Year: 2024, Volume and Issue: 15(2), P. 163 - 205

Published: April 18, 2024

Despite their subordination in humans, to a great extent, mitochondria maintain independent status but tightly cooperate with the "host" on protecting joint life quality and minimizing health risks. Under oxidative stress conditions, healthy promptly increase mitophagy level remove damaged "fellows" rejuvenating mitochondrial population sending fragments of mtDNA as SOS signals all systems human body. As long metabolic pathways are under systemic control well-concerted together, adaptive mechanisms become triggered increasing protection, activating antioxidant defense repair machinery. Contextually, attributes patho-/physiology instrumental for predictive medical approach cost-effective treatments tailored individualized patient profiles primary (to protect vulnerable individuals again health-to-disease transition) secondary affected disease progression) care. Nutraceuticals naturally occurring bioactive compounds demonstrating health-promoting, illness-preventing, other health-related benefits. Keeping mind health-promoting properties nutraceuticals along therapeutic potential safety profile, there is permanently growing demand application mitochondria-relevant nutraceuticals. Application beneficial only if meeting needs at individual level. Therefore, risk assessment creation pivotal importance followed by adapted nutraceutical sets needs. Based scientific evidence available nutraceuticals, this article presents examples frequent which require protective measures targeted holistic following advanced concepts predictive, preventive, personalized medicine (PPPM/3PM)

Language: Английский

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The protective role of ginsenoside Rg3 in heart diseases and mental disorders

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 26, 2024

Ginsenoside Rg3, a compound derived from

Language: Английский

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