Adverse health effects and mechanisms of microplastics on female reproductive system: a descriptive review DOI

Vishal Afreen,

Kanza Hashmi,

Rimsha Nasir

et al.

Environmental Science and Pollution Research, Journal Year: 2023, Volume and Issue: 30(31), P. 76283 - 76296

Published: May 29, 2023

Language: Английский

Microplastic pollution in soils, plants, and animals: A review of distributions, effects and potential mechanisms DOI
Xiao Chang, Yi Fang, Ying Wang

et al.

The Science of The Total Environment, Journal Year: 2022, Volume and Issue: 850, P. 157857 - 157857

Published: Aug. 4, 2022

Language: Английский

Citations

163
The emerging role of microplastics in systemic toxicity: Involvement of reactive oxygen species (ROS) DOI
Amlan Das

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 895, P. 165076 - 165076

Published: June 28, 2023

Language: Английский

Citations

147
The potential toxicity of microplastics on human health DOI

Bosen Zhao,

Palizhati Rehati, Zhu Yang

et al.

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 912, P. 168946 - 168946

Published: Dec. 2, 2023

Language: Английский

Citations

106
Polystyrene microplastics promote liver inflammation by inducing the formation of macrophages extracellular traps DOI

Kai Yin,

Dongxu Wang, Yue Zhang

et al.

Journal of Hazardous Materials, Journal Year: 2023, Volume and Issue: 452, P. 131236 - 131236

Published: March 21, 2023

Language: Английский

Citations

84
Gut Microbiota Participates in Polystyrene Microplastics-Induced Hepatic Injuries by Modulating the Gut–Liver Axis DOI

Kai-Kai Zhang,

Jian-Zheng Yang, Lijian Chen

et al.

ACS Nano, Journal Year: 2023, Volume and Issue: 17(15), P. 15125 - 15145

Published: July 24, 2023

Dietary pollution by polystyrene microplastics (MPs) can cause hepatic injuries and microbial dysbiosis. Epigallocatechin-3-gallate (EGCG), the major polyphenol in green tea, exerts beneficial effects on liver modulating gut microbiota. However, role of microbiota MPs-induced protective effect EGCG have not been clarified. Here, 5 μm MPs were orally administered to mice induce injuries. Subsequently, antibiotic cocktail (ABX) fecal transplant (FMT) experiments performed investigate underlying mechanisms. Additionally, was explore its protection against Our results showed that activated systemic inflammation, promoted fibrosis, altered metabolome; meanwhile, damaged homeostasis disturbing microbiome, promoting colonic impairing intestinal barrier. Notably, reduced abundance probiotics Akkermansia, Mucispirillum, Faecalibaculum while increasing pathogenic Tuzzerella. Interestingly, elimination mitigated inflammation barrier impairment. Moreover, ABX ameliorated but fibrosis. Correspondingly, from MPs-administered induced colonic, systemic, their profibrosis observed. Finally, elevated effectively repressed inflammation. remodeling metabolome also attenuated EGCG. These findings illustrated contributed injuries, could serve as a potential prevention strategy for these adverse consequences.

Language: Английский

Citations

83
Prenatal and postnatal exposure to polystyrene microplastics induces testis developmental disorder and affects male fertility in mice DOI Creative Commons

Tianxin Zhao,

Lianju Shen,

Xin Ye

et al.

Journal of Hazardous Materials, Journal Year: 2022, Volume and Issue: 445, P. 130544 - 130544

Published: Dec. 5, 2022

Polystyrene microplastics (PS-MPs) can threaten human health, especially male fertility. However, most existing studies have focused on the adulthood stage of reproduction toxicity caused by relatively short-term PS-MP exposure. This study aimed to investigate toxic effect PS-MPs testicular development and reproductive function upon prenatal postnatal Pregnant mice their offspring were exposed 0, 0.5 mg/L, 5 50 mg/L through daily drinking water from gestational day 1 (PND) 35 or PND70. We found that exposure induced testis disorder PND35 spermatogenesis dysfunction By combining RNA sequencing results bioinformatics analysis, hormone-mediated signaling pathway, G1/S transition mitotic cell cycle, coregulation androgen receptor activity, Hippo pathway shown be involved in PND35. The meiotic regulation immune effector process, neutrophil degranulation, inflammation mediated chemokine cytokine pathways associated with disturbed These findings show resulted subfertility, which may regulated involve an reaction.

Language: Английский

Citations

77
A systematic review of the impacts of exposure to micro- and nano-plastics on human tissue accumulation and health DOI Creative Commons
Yudong Feng,

Chen Tu,

Ruijie Li

et al.

Eco-Environment & Health, Journal Year: 2023, Volume and Issue: 2(4), P. 195 - 207

Published: Aug. 21, 2023

Micro- and nano-plastics (MNPs) pollution has become a pressing global environmental issue, with growing concerns regarding its impact on human health. However, evidence the effects of MNPs health remains limited. This paper reviews three routes exposure to MNPs, which include ingestion, inhalation, dermal contact. It further discusses potential translocation in lungs, intestines, skin, analyses homeostasis organ systems, provides an outlook future research priorities for There is that are present tissues or fluids. Lab studies, including

Language: Английский

Citations

74
Human Microplastics Exposure and Potential Health Risks to Target Organs by Different Routes: A Review DOI
Ziye Yang,

Meixue Wang,

Zhihong Feng

et al.

Current Pollution Reports, Journal Year: 2023, Volume and Issue: 9(3), P. 468 - 485

Published: Aug. 17, 2023

Language: Английский

Citations

58
Exposure to nanoplastics induces mitochondrial impairment and cytomembrane destruction in Leydig cells DOI Creative Commons

Zhangbei Sun,

Yiqian Wen,

Fan Zhang

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2023, Volume and Issue: 255, P. 114796 - 114796

Published: March 20, 2023

Plastic particle pollution poses an emerging threat to ecological and human health. Laboratory animal studies have illustrated that nano-sized plastics can accumulate in the testis cause testosterone deficiency spermatogenic impairment. In this study, TM3 mouse Leydig cells were vitro exposed polystyrene nanoparticles (PS-NPs, size 20 nm) at dosages of 50, 100 150 μg/mL investigate their cytotoxicity. Our results demonstrated PS-NPs be internalized into led a concentration-dependent decline cell viability. Furthermore, stimulation amplified ROS generation initiated cellular oxidative stress apoptosis. Moreover, treatment affected mitochondrial DNA copy number collapsed membrane potential, accompanied by disrupted energy metabolism. The also displayed down-regulated expression steroidogenesis-related genes StAR, P450scc 17β-HSD, along with decrease secretion. addition, destructed plasma integrity, as presented increase lactate dehydrogenase release depolarization potential. summary, these data indicated exposure produced cytotoxic effect on inducing injury, impairment, apoptosis, cytomembrane destruction. provide new insights male reproductive toxicity caused NPs.

Language: Английский

Citations

55
The gut-brain axis involved in polystyrene nanoplastics-induced neurotoxicity via reprogramming the circadian rhythm-related pathways DOI

Huiwen Kang,

Wei Zhang, Jiaru Jing

et al.

Journal of Hazardous Materials, Journal Year: 2023, Volume and Issue: 458, P. 131949 - 131949

Published: June 29, 2023

Language: Английский

Citations

44