Genes,
Journal Year:
2023,
Volume and Issue:
14(12), P. 2217 - 2217
Published: Dec. 14, 2023
Major
depressive
disorder
(MDD)
is
a
complex
and
leading
cause
of
disability
in
280
million
people
worldwide.
Many
environmental
factors,
such
as
microbes,
drugs,
diet,
are
involved
the
pathogenesis
disorders.
However,
underlying
mechanisms
depression
include
interaction
genetics
with
epigenetics
host
immune
system.
Modifications
gut
microbiome
its
metabolites
influence
stress-related
responses
social
behavior
patients
disorders
by
modulating
maturation
cells
neurogenesis
brain
mediated
epigenetic
modifications.
Here,
we
discuss
potential
roles
leaky
development
via
changes
microbiota-derived
effects.
Next,
will
deliberate
how
altering
composition
contributes
to
alterations.
In
particular,
focus
on
butyrate
an
modifier,
probiotics,
maternal
polyphenols,
drugs
(e.g.,
antipsychotics,
antidepressants,
antibiotics),
fecal
microbiota
transplantation
could
positively
alleviate
depressive-like
behaviors
landscape.
Finally,
challenges
associated
recent
therapeutic
approaches
for
microbiome-related
shifts,
well
opportunities
tackle
problems.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(13), P. 7175 - 7175
Published: June 29, 2024
Obesity
is
a
global
health
challenge
that
has
received
increasing
attention
in
contemporary
research.
The
gut
microbiota
been
implicated
the
development
of
obesity,
primarily
through
its
involvement
regulating
various
host
metabolic
processes.
Recent
research
suggests
epigenetic
modifications
may
serve
as
crucial
pathways
which
and
metabolites
contribute
to
pathogenesis
obesity
other
disorders.
Hence,
understanding
interplay
between
mechanisms
for
elucidating
impact
on
host.
This
review
focuses
relationship
with
several
obesity-related
pathogenic
mechanisms,
including
energy
dysregulation,
inflammation,
maternal
inheritance.
These
findings
could
novel
therapeutic
targets
probiotics,
prebiotics,
fecal
transplantation
tools
treating
disruptions.
It
also
aid
developing
strategies
modulate
microbiota,
thereby
characteristics
obesity.
Cell Discovery,
Journal Year:
2025,
Volume and Issue:
11(1)
Published: March 17, 2025
Abstract
According
to
traditional
Chinese
medicine
(TCM)
constitutional
theory,
individuals
with
phlegm-dampness
constitution
(PDC)
are
at
increased
risk
for
metabolic
disorders.
Previous
studies
have
indicated
that
PDC
exhibit
gene
expression
changes
associated
disorders,
even
normal
indices.
However,
the
biological
mechanisms
underlying
these
remain
unclear.
The
gut
microbiota
has
recently
emerged
as
a
promising
avenue
elucidating
TCM
principles.
Here,
we
revealed
distinct
and
serum
metabolite
profiles.
A
decrease
in
phytosphingosine
was
scores
disorder
severity.
Subsequent
experiments
demonstrated
Flavonifractor
plautii
can
biosynthesize
phytosphingosine,
which
also
negatively
correlated
score.
Interestingly,
both
F.
levels
decreased
subjects
Fecal
transplantation
from
accelerated
development
of
disorders
mice.
supplementation
ameliorated
by
increasing
gut‒hepatic
axis.
Mechanistic
investigations
confirmed
directly
bind
hepatic
peroxisome
proliferator-activated
receptor
α
(PPARα)
activate
its
nuclear
transcription
activity,
thereby
regulating
downstream
related
glucose‒lipid
metabolism.
Our
research
indicates
product,
contributes
increases
their
susceptibility
These
findings
suggest
diagnosing
may
be
beneficial
identifying
at-risk
populations
among
apparently
healthy
individuals,
advancing
broader
field
prevention
integration.
Results in Chemistry,
Journal Year:
2024,
Volume and Issue:
8, P. 101556 - 101556
Published: May 24, 2024
Hybrid
molecules
based
on
the
1,3,4-thiadiazole
were
always
choice
of
different
researchers
due
to
their
significant
application
in
medicinal
as
well
pharmaceutical
application.
In
present
study,
twenty
analogs
1,3,4-thiadiazole-bearing
thiosemicarbazide
moiety
(1–20)
synthesized
and
screened
for
anti-diabetic
profile.
The
compounds
spectroscopically
characterized
through
spectroscopic
techniques
such
1HNMR,
13CNMR,
HREI-MS.
Comparing
whole
set
afforded
standard
glimepiride
drugs
(16.01
±
0.02
μM),
inhibition
profiles
against
α-amylase
ranged
from
21.02
0.08
54.08
0.04
μM.
synthetic
normal
(IC50
=
14.06
0.05
range
α-glucosidase
activity
was
likewise
variable,
ranging
18.04
0.07
μM
IC50
51.05
0.03
(against
α-glucosidase).
Compound
19
demonstrated
high
potency
among
produced
since
it
had
both
ortho-nitro
substitution
at
aryl
ring.
pattern
substitutions
around
ring
used
all
determine
structure–activity
relationship.
addition,
a
molecular
docking
study
conducted
potent
examine
interactions
between
active
residues
targeted
enzymes
with
compound.
molecule
showed
types
amino
acid.
outcome
demonstrates
that
these
provide
several
essential
sites
enzymes,
hence
strengthening
enzymatic
future
prediction
drug
competitors.
Animal Models and Experimental Medicine,
Journal Year:
2024,
Volume and Issue:
7(5), P. 641 - 652
Published: June 28, 2024
Short-chain
fatty
acids
(SCFAs)
are
major
metabolites
produced
by
the
gut
microbiota
through
fermentation
of
dietary
fiber,
and
they
have
garnered
significant
attention
due
to
their
close
association
with
host
health.
As
important
mediators
between
host,
SCFAs
serve
as
energy
substrates
for
intestinal
epithelial
cells
maintain
homeostasis
in
immune
metabolism
influencing
epigenetics,
activating
G
protein-coupled
receptors,
inhibiting
pathogenic
microbial
infections.
This
review
provides
a
comprehensive
summary
synthesis
offering
an
overview
latest
research
progress
on
roles
protecting
health,
enhancing
metabolism,
mitigating
diseases
such
cancer,
obesity,
diabetes,
modulating
gut-brain
axis
gut-lung
axis,
promoting
bone
Alexandria Engineering Journal,
Journal Year:
2024,
Volume and Issue:
93, P. 80 - 89
Published: March 14, 2024
The
purpose
of
this
work
was
to
construct
an
electrochemical
sensor
for
the
detection
imatinib.
It
based
on
a
modified
glassy
carbon
electrode
(chitosan/rGO/GCE)
that
reduced
graphene
oxide
nanocomposite.
By
employing
straightforward
drop-casting
technique,
rGO/chitosan
composite
applied
GCE
surface.
XRD,
FT-IR,
and
FE-SEM
structural
studies
verified
successfully
nanocomposite
formed.
synergistic
effect
rGO
chitosan
boosted
electron
transfer
kinetics
facilitated
oxidation
reaction
imatinib
surface,
according
experiments,
which
indicated
chitosan/rGO/GCE's
sensitive,
selective,
stable
response
findings
showed
sensitivity
0.16502
μA/μM,
limit
value
7.3
nM,
wide
linear
range
1–300
µM.
Differential
pulse
voltammetry
measurements
were
performed
prepared
human
serum
urine
samples
evaluate
applicability
chitosan/rGO/GCE
in
real
samples.
For
genuine
samples,
good
recoveries
ranging
from
95.00%
99.20%
with
relative
standard
deviation
3.10–4.49%.
These
variety
may
be
accurately
analyzed
using
chitosan/rGO/GCE.
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: Feb. 13, 2024
The
strong
ethnopharmacological
utilization
of
Isodon
rugosus
Wall.
Ex.
Benth
is
evident
in
the
treatment
several
types
pain
and
inflammation,
including
toothache,
earache,
abdominal
pain,
gastric
generalized
body
inflammation.
Based
on
this
background,
antinociceptive
effects
crude
extract,
various
fractions,
essential
oil
have
been
reported
previously.
In
research
work,
we
isolate
characterize
pure
bioactive
compounds
from
I.
evaluate
possible
mechanisms
using
vivo
vitro
models.
were
analyzed
for
analgesic
anti-inflammatory
activities
through
assays.
column
chromatography
chloroform
fraction
led
to
identification
two
compounds,
i.e.,
1
2.
Compound
demonstrated
notable
inhibition
(62%
writhing
inhibition,
72.77%
COX-2
76.97%
5-LOX
inhibition)
potential
(>50%
paw
edema
at
intervals).
mechanism
involved
antinociception
was
considered
primarily,
a
concept
that
has
already
elucidated
application
naloxone
(an
antagonist
opioid
receptors).
involvement
adrenergic
receptors
investigated
hot
plate
model
receptor
antagonist).
ethnomedicinal
background
,
supported
by
previous
reports
current
observations,
leads
conclusion
source
compounds.
It
may
be
concluded
results
isolated
alternative
remedy
inflammation
management
with
admirable
efficacy
safety
profiles.
