Microplastic contamination in the agricultural soil—mitigation strategies, heavy metals contamination, and impact on human health: a review

Plant Cell Reports, Journal Year: 2024, Volume and Issue: 43(3)

Published: Feb. 10, 2024

Language: Английский

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Exosomes: a review of biologic function, diagnostic and targeted therapy applications, and clinical trials

Journal of Biomedical Science, Journal Year: 2024, Volume and Issue: 31(1)

Published: July 11, 2024

Abstract Exosomes are extracellular vesicles generated by all cells and they carry nucleic acids, proteins, lipids, metabolites. They mediate the exchange of substances between cells,thereby affecting biological properties activities recipient cells. In this review, we briefly discuss composition exocomes exosome isolation. We also review clinical applications exosomes in cancer biology as well strategies exosome-mediated targeted drug delivery systems. Finally, application context therapeutics both practice literature discussed.

Language: Английский

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Research status and challenges of plant-derived exosome-like nanoparticles

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 174, P. 116543 - 116543

Published: April 11, 2024

In recent years, there has been an increasing number of related studies on exosomes. Most have focused exosomes derived from mammals, confirming the important role that play in cell communication. Plants, as a natural ingredient, plant-derived confirmed to similar structures and functions mammalian-derived Plant-derived exosome-like nanoparticles (PELNs) are lipid bilayer membrane nanovesicles containing bioactive constituents such miRNA, mRNA, protein, lipids obtained plant cells, can participate intercellular communication mediate transboundary communication, high bioavailability low immunogenicity, relatively safe, shown maintaining homeostasis preventing, treating variety diseases. this review, we describe biogenesis, isolation purification methods, structural composition, stability, safety, function PELNs challenges. The anti-inflammatory, antioxidant, antitumor drug delivery mainly described, status research exosome Chinese herbal medicines is outlined. Overall, summarized importance latest results field provided theoretical basis for future clinical application PELNs.

Language: Английский

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Isolation of plant-derived exosome-like nanoparticles (PDENs) from Solanum nigrum L. berries and Their Effect on interleukin-6 expression as a potential anti-inflammatory agent

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(1), P. e0296259 - e0296259

Published: Jan. 4, 2024

Inflammation is a temporary response of the immune system that can be treated using common anti-inflammatory drugs. However, prolonged use these drugs increases risk adverse side effects. Accordingly, there an increasing need for alternative treatments inflammation with fewer Exosomes are extracellular vesicles secreted by most eukaryotic cells and have been studied as candidate cell-free therapy inflammatory diseases due to their immunomodulatory properties. In recent years, focus exosome research has shifted from animal cell-derived exosomes plant-derived exosome-like nanoparticles (PDENs). Plant-derived (PDENs) easier obtain, minimal safety concerns, produced in higher quantities lower cost than derived cells. this study, isolation analysis potential PDENs black nightshade berries ( Solanum nigrum L.) were carried out. The results characterization showed had spherical morphology, measuring around 107 nm zeta -0.6 mV, protein concentration 275.38 μg/mL. also shown internalized RAW264.7 macrophage cell line after 2 hours incubation no cytotoxicity effect up 2.5 Furthermore, exposure several doses LPS-stimulated significantly decreased expression pro-inflammatory cytokine gene IL-6, well IL-6 97,28%. GC-MS presence neral, monoterpene compound known properties, which may contribute activity isolated L. berries. Taken together, present study was first isolate characterize demonstrated PDEN suppressing production

Language: Английский

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Bioactive compounds and biological functions of medicinal plant-derived extracellular vesicles

Pharmacological Research, Journal Year: 2024, Volume and Issue: 200, P. 107062 - 107062

Published: Jan. 9, 2024

Extracellular vesicles (EVs) are tiny lipid bilayer-enclosed membrane particles released from a variety of cell types into the surrounding environment. These EVs have massive participated in cell-to-cell communication and interspecies communication. In recent years, plant-derived extracellular (PDEVs) "exosome-like" populations found distinct plants attracted widespread attention. Especially, research on medicinal (MPDEVs) increasing, which considered kind promising natural compound. This review summarizes current knowledge MPDEVs terms bioactive compounds, including small RNA, protein, lipid, metabolite, been surface and/or lumen MPDEVs. Moreover, both vitro vivo experiments shown that exert broad biomedical functions, such as anti-inflammatory, anticancer, antioxidant, modulate microbiota, etc. may be better substitute than animal-derived (ADEVs) because safety biocompatibility future.

Language: Английский

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Plant-Derived Exosome-Like Nanoparticles: Emerging Nanosystems for Enhanced Tissue Engineering

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 1189 - 1204

Published: Feb. 1, 2024

Abstract: Tissue engineering holds great potential for tissue repair and rejuvenation. Plant-derived exosome-like nanoparticles (ELNs) have recently emerged as a promising avenue in engineering. However, there is an urgent need to understand how plant ELNs can be therapeutically applied clinical disease management, especially regeneration. In this review, we comprehensively examine the properties, characteristics, isolation techniques of ELNs. We also discuss their impact on immune system, compatibility with human body, role To ensure suitability engineering, explore various modification strategies. Additionally, provide insights into progress commercialization industrial perspectives This review aims highlight regenerative medicine by exploring current research landscape key findings. Keywords: plant, nanoparticles, nanomedicine, cartilage, wound, bone

Language: Английский

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Multifaceted Therapeutic Potential of Plant-Derived Exosomes: Immunomodulation, Anticancer, Anti-Aging, Anti-Melanogenesis, Detoxification, and Drug Delivery

Biomolecules, Journal Year: 2025, Volume and Issue: 15(3), P. 394 - 394

Published: March 10, 2025

Most eukaryotic and prokaryotic cells have the potential to secrete a group of structures/membrane-bound organelles, collectively referred as extracellular vesicles (EVs), which offer several advantages producer/receiver cells. This review provides an overview EVs from plant sources with emphasis on their health-promoting possible use therapeutic agents. highlights essential biological effects plant-derived vesicles, including immune modulation, anticancer activities, protection against chemical toxicity pathogens, well anti-aging, anti-melanogenesis, anti-arthritic effects, along ongoing clinical studies. Evidence revealed that EVs’ contents exert beneficial properties through regulating important signaling pathways by transferring miRNAs other components. Taken all together, data proposed can be utilized nutritional compounds agents, such drug carriers. However, this emerging research area requires further in vitro/in vivo studies trials determine exact underlying mechanisms positive health treating various diseases.

Language: Английский

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Triple Cross‐linked Dynamic Responsive Hydrogel Loaded with Selenium Nanoparticles for Modulating the Inflammatory Microenvironment via PI3K/Akt/NF‐κB and MAPK Signaling Pathways

Advanced Science, Journal Year: 2023, Volume and Issue: 10(31)

Published: Sept. 22, 2023

Modulating the inflammatory microenvironment can inhibit process of diseases (IDs). A tri-cross-linked microenvironment-responsive hydrogel with ideal mechanical properties achieves triggerable and sustained drug delivery regulates microenvironment. Here, this study develops an (OD-PP@SeNPs) composed phenylboronic acid grafted polylysine (PP), oxidized dextran (OD), selenium nanoparticles (SeNPs). The introduction SeNPs as initiators nano-fillers into results in extra cross-linking polymer network through hydrogen bonding. Based on Schiff base bonds, Phenylboronate ester a reactive oxygen species (ROS)/pH dual responsive triple-network is achieved. has injectable, self-healing, adhesion, outstanding flexibility, suitable swelling capacity, optimal biodegradability, excellent stimuli-responsive active substance release performance, prominent biocompatibility. Most importantly, ROS scavenging pH-regulating ability protects cells from oxidative stress induces macrophages M2 polarization to reduce cytokines PI3K/AKT/NF-κB MAPK pathways, exerting anti-inflammatory effects reshaping microenvironment, thereby effectively treating typical IDs, including S. aureus infected wound rheumatoid arthritis rats. In conclusion, dynamically injectable structure provides effective strategy treat holding great promise clinical application.

Language: Английский

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Biomaterial-based scaffolds in promotion of cartilage regeneration: Recent advances and emerging applications

Journal of Orthopaedic Translation, Journal Year: 2023, Volume and Issue: 41, P. 54 - 62

Published: July 1, 2023

Osteoarthritis (OA) poses a significant burden for countless individuals, inflicting relentless pain and impairing their quality of life. Although traditional treatments OA focus on management surgical interventions, they often fall short addressing the underlying cause disease. Fortunately, emerging biomaterial-based scaffolds offer hope therapy, providing immense promise cartilage regeneration in OA. These innovative are ingeniously designed to provide support mimic intricate structure natural extracellular matrix, thus stimulating damaged cartilage. In this comprehensive review, we summarize discuss current landscape Furthermore, delve into diverse range biomaterials employed construction explore cutting-edge techniques utilized fabrication. By examining both preclinical clinical studies, aim illuminate remarkable versatility untapped potential context thoroughly state research review provides valuable insights that bridge gap between scientific knowledge practical application. This is crucial clinicians researchers who strive develop go beyond symptom directly target Through analysis multidisciplinary approach, paves way translation applications, ultimately improving lives individuals suffering from shaping future orthopedic medicine.

Language: Английский

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Edible plant-derived extracellular vesicles serve as promising therapeutic systems

Nano TransMed, Journal Year: 2023, Volume and Issue: 2(2-3), P. 100004 - 100004

Published: Sept. 1, 2023

Extracellular vesicles (EVs), which are natural nanocarriers characterized by a phospholipid bilayer structure, released living cells. They play crucial role in the intercellular transport of proteins, nucleic acids, lipids, and metabolites, facilitating substance delivery information exchange between In light recent numerous studies, EVs has been found to transcend their basic as mere vehicle. Instead, they demonstrate an impressive array biological activities, displaying preventive therapeutic potential mitigating various pathological processes encompassing cancer, neoplastic proliferation, infectious diseases, oxidative trauma. Particularly, derived from edible plants (EPDEVs) have emphasized for extensive range physiological regulatory functions animals humans, with targeted drug through oral administration. Leveraging these advantages, EPDEVs expected excellent competitiveness clinical applications or healthcare products. This review provides brief overview biogenesis, composition EPDEVs, summarizes mechanisms. It also analyzes methods isolating purifying plant-EVs, assessing advantages disadvantages; discusses latest advancements biomedical applications, concludes prospective insight into research development directions EPDEVs.

Language: Английский

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