Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(11), P. 1373 - 1373
Published: Nov. 9, 2024
Plant-Derived
Extracellular
Vesicles
extracellular
vesicles
(PDEVs)
from
organic
agriculture
(without
the
use
of
pesticides
and
microbicides)
contain
high
levels
antioxidants.
Organic
PDEVs
have
shown
an
increased
antioxidant
power
compared
to
single
plants,
suggesting
a
synergistic
effect
bioactives
constitutively
expressed
in
fruits.
With
this
study,
we
wanted
investigate
beneficial
effects
mix
on
human
skin
cells.
We
found
detectable
citric
acid,
ascorbic
glutathione,
catalase,
SOD
deriving
five
different
fruits
(grape,
red
orange,
papaya,
pomegranate,
tangerine).
then
treated
H
Pharmacological Research,
Journal Year:
2024,
Volume and Issue:
200, P. 107062 - 107062
Published: Jan. 9, 2024
Extracellular
vesicles
(EVs)
are
tiny
lipid
bilayer-enclosed
membrane
particles
released
from
a
variety
of
cell
types
into
the
surrounding
environment.
These
EVs
have
massive
participated
in
cell-to-cell
communication
and
interspecies
communication.
In
recent
years,
plant-derived
extracellular
(PDEVs)
"exosome-like"
populations
found
distinct
plants
attracted
widespread
attention.
Especially,
research
on
medicinal
(MPDEVs)
increasing,
which
considered
kind
promising
natural
compound.
This
review
summarizes
current
knowledge
MPDEVs
terms
bioactive
compounds,
including
small
RNA,
protein,
lipid,
metabolite,
been
surface
and/or
lumen
MPDEVs.
Moreover,
both
vitro
vivo
experiments
shown
that
exert
broad
biomedical
functions,
such
as
anti-inflammatory,
anticancer,
antioxidant,
modulate
microbiota,
etc.
may
be
better
substitute
than
animal-derived
(ADEVs)
because
safety
biocompatibility
future.
Plants,
Journal Year:
2023,
Volume and Issue:
12(24), P. 4141 - 4141
Published: Dec. 12, 2023
Plant
cells
secrete
membrane-enclosed
micrometer-
and
nanometer-sized
vesicles
that,
similarly
to
the
extracellular
(EVs)
released
by
mammalian
or
bacterial
cells,
carry
a
complex
molecular
cargo
of
proteins,
nucleic
acids,
lipids,
primary
secondary
metabolites.
While
it
is
technically
complicated
isolate
EVs
from
whole
plants
their
tissues,
in
vitro
plant
cell
cultures
provide
excellent
model
systems
for
study.
have
been
isolated
conditioned
culture
media
cell,
pollen,
hairy
root,
protoplast
cultures,
recent
studies
gathered
important
structural
biological
data
that
framework
decipher
physiological
roles
unveil
previously
unacknowledged
links
diverse
functions.
The
function
seems
be
secretion
underlies
growth
morphogenesis,
wall
composition,
cell-cell
communication
processes.
Besides
functions,
may
participate
defence
mechanisms
against
different
pathogens,
including
fungi,
viruses,
bacteria.
Whereas
edible
medicinal-plant-derived
nanovesicles
homogenised
materials
ex
vivo
are
widely
studied
exploited,
today,
EV
research
still
its
infancy.
This
review,
first
time,
highlights
sources
used
EVs,
together
with
investigate
cargo,
pinpoints
possible
role
as
mediators
plant-pathogen
interactions,
which
contribute
opening
up
new
scenarios
agricultural
applications,
biotechnology,
innovative
strategies
disease
management.
View,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 21, 2025
Abstract
Extracellular
vesicles
(EVs)
are
nano‐sized
surrounded
by
a
lipid
bilayer
containing
bioactive
materials,
including
proteins,
nucleic
acids,
lipids,
and
metabolites.
They
function
as
messengers
secreted
cells,
playing
crucial
role
in
cell‐to‐cell
communication.
Plant‐derived
extracellular
(P‐EVs),
plant
being
investigated
therapeutic
agents
drug
delivery
carriers
due
to
their
high
biocompatibility,
productivity,
effective
cellular
delivery,
exerting
effects
through
physiological
pathways.
However,
methods
for
EV
production
directly
from
plants
P‐EV
identification
components
have
not
yet
been
established.
A
comprehensive
understanding
of
the
potential
biodistribution
P‐EVs
is
essential
application
systemic
therapeutics
carriers.
This
review
covers
recent
separating
explores
identification.
It
also
summarizes
intrinsic
applications
engineered
P‐EVs.
Finally,
it
provides
tailored
strategies
examining
according
route
administration
analyzing
application.
Given
diversity
distinctiveness
plants,
development
using
shows
great
promise
anticipated
create
new
paradigm
therapeutics.
Tissue Engineering Part B Reviews,
Journal Year:
2024,
Volume and Issue:
30(6), P. 607 - 630
Published: March 14, 2024
Regenerative
medicine
aims
to
restore
the
function
of
diseased
or
damaged
tissues
and
organs
by
cell
therapy,
gene
tissue
engineering,
along
with
adjunctive
application
bioactive
molecules.
Traditional
molecules
such
as
growth
factors
cytokines
have
shown
great
potential
in
regulation
cellular
behavior,
but
disadvantages
limited
source,
high
cost,
short
half-life,
side
effects.
In
recent
years,
herbal
compounds
extracted
from
natural
plants/herbs
gained
increasing
attention.
This
is
not
only
because
are
easily
obtained,
inexpensive,
mostly
safe,
reliable,
also
owing
their
excellent
effects
including
anti-inflammatory,
antibacterial,
antioxidative,
proangiogenic
behavior
ability
promote
stem
differentiation.
Such
play
important
roles
processes
related
regeneration.
Furthermore,
moieties
can
form
physical
chemical
bonds
scaffolds,
which
contributes
improved
mechanical
strength
stability
scaffolds.
Thus,
incorporation
biomaterials
a
promising
direction
for
future
regenerative
applications.
Herein,
an
overview
on
use
combined
different
biomaterial
scaffolds
presented.
We
firstly
introduce
classification,
structures,
properties
components
then
provide
comprehensive
survey
engineer
repair/regeneration
skin,
cartilage,
bone,
neural,
heart
tissues.
Finally,
we
highlight
challenges
prospects
development
toward
clinical
translation.
Overall,
it
believed
that
combination
could
be
perspective
next
generation
medicine.
Processes,
Journal Year:
2024,
Volume and Issue:
12(12), P. 2938 - 2938
Published: Dec. 23, 2024
Plant-derived
extracellular
vesicles
(PDEVs)
are
lipid
bilayer
nanoparticles,
naturally
produced
by
plant
cells,
with
sizes
ranging
from
50
to
500
nm.
Recent
studies
have
highlighted
their
great
potential
in
the
biotechnological
and
medical
fields,
due
natural
origin,
high
biocompatibility
intrinsic
therapeutic
properties.
PDEVs
contain
a
complex
biological
cargo
of
proteins,
lipids,
nucleic
acids
secondary
metabolites,
including
antioxidants
anti-inflammatory
molecules,
making
them
ideal
for
biomedical
applications
such
as
drug
delivery.
These
play
key
role
intercellular
communication
gene
regulation,
proving
be
particularly
promising
personalized
medicine.
ability
improve
stability
bioavailability,
optimizing
targeted
release
minimizing
side
effects.
Despite
some
challenges,
compositional
variability
need
standardized
protocols,
at
gunsight
innovative
research
aimed
improving
loading
capacity
specificity.
This
review
aims
provide
comprehensive
overview
PDEVs,
exploring
structure,
isolation
methods,
functional
characteristics,
applications,
highlighting
advantages
over
synthetic
nanoparticles
animal-derived
vesicles,
leading
an
sustainable
solution
development
new
approaches.
Burns & Trauma,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 23, 2025
Abstract
Burn
injuries
are
associated
with
high
morbidity
and
mortality,
severe
burns
trigger
many
pathophysiological
reactions,
such
as
metabolic
changes,
distributive
shock,
inflammatory
responses,
which
potentially
devastating
to
patients.
wound
management
necessitates
infection
prevention,
anti-inflammation,
pain
management,
growth
factor
but
significant
obstacles
remain.
Extracellular
vesicles
(EVs)
lipid
bilayer
secreted
by
various
cell
types,
including
mammalian
cells,
plant
even
prokaryotes,
They
widely
involved
in
biological
processes,
survival,
neovascularization,
immunomodulation.
EVs
abundant
components
that
can
play
a
role
different
stages
of
repair
at
subcellular
levels
simultaneously
transporting
active
contents,
proteins
nucleic
acids.
Moreover,
detectable
biofluids
burn
injury
patients
thus
regarded
novel
biomarkers
for
monitoring
therapeutic
response
predicting
prognosis.
This
review
summarizes
the
roles
their
mechanisms
action
summarized.
The
prospects
opportunities
clinical
application
wounds
also
discussed.
will
stimulate
guide
additional
in-depth
studies
repair,
provide
new
therapy
wounds,
reference
guidance
applying
repair.
Advanced NanoBiomed Research,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 30, 2025
Plant‐derived
extracellular
vesicles
(pEVs)
are
nanosized
that
have
comparable
structure
and
properties
to
EVs
derived
from
mammalian
cells.
Prior
studies
confirmed
pEVs
remarkable
efficacy
in
the
treatment
of
human
diseases,
such
as
cancer.
As
critical
regulators
gene
expression,
microRNAs
(miRNAs)
abundant
pEVs.
However,
their
potential
functional
roles
regulatory
mechanisms
mediating
crosskingdom
regulation
cells
by
remain
undefined.
In
particular,
similarities
differences
miRNA
profiles
various
elusive.
Herein,
isolated
grapefruit,
ginger,
lemon,
grape,
small
RNA
(sRNA)
libraries
constructed
perform
sRNA
sequencing.
Only
15
consistently
expressed
miRNAs
identified
these
Furthermore,
top
20
each
pEV
highly
among
total
miRNAs,
accounting
for
79.93–87.12%.
Through
annotation
analysis
target
genes,
found
be
involved
regulating
progression
cancer
viral
infection.
Taken
together,
this
study
demonstrates
contained
play
a
role
effects
against
genes
highlights
significant
therapeutic
applications
diseases.
