Advancing the pH-driven encapsulation technique of curcumin: Molecular interaction shifts due to structural and charge variations

Food Hydrocolloids, Journal Year: 2024, Volume and Issue: 152, P. 109952 - 109952

Published: Feb. 28, 2024

Language: Английский

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Synthesis, optimization via response surface methodology, and structural properties of carboxymethylcellulose/curcumin/graphene oxide biocomposite films/coatings for the shelf-life extension of shrimp

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 253, P. 126724 - 126724

Published: Sept. 9, 2023

Language: Английский

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Nanocrystals and nanosuspensions: an exploration from classic formulations to advanced drug delivery systems

Drug Delivery and Translational Research, Journal Year: 2024, Volume and Issue: 14(12), P. 3438 - 3451

Published: March 7, 2024

Abstract Nanocrystals and nanosuspensions have become realistic approaches to overcome the formulation challenges of poorly water-soluble drugs. They also represent a less-known but versatile platform for multiple therapeutic applications. can be integrated into broad spectrum drug delivery systems including tablets, hydrogels, microneedles, microparticles, or even functionalized liposomes. The recent progresses, challenges, opportunities in this field are gathered originally together with an informative case study concerning itraconazole nanosuspension-in-hydrogel formulation. translational aspects, historical current clinical perspectives critically reviewed here shed light on incoming generation nanocrystal formulations.

Language: Английский

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Targeting different phenotypes of macrophages: A potential strategy for natural products to treat inflammatory bone and joint diseases

Phytomedicine, Journal Year: 2023, Volume and Issue: 118, P. 154952 - 154952

Published: July 12, 2023

Language: Английский

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Macrophage-related therapeutic strategies: Regulation of phenotypic switching and construction of drug delivery systems

Pharmacological Research, Journal Year: 2023, Volume and Issue: 199, P. 107022 - 107022

Published: Dec. 1, 2023

Macrophages, as highly phenotypic plastic immune cells, play diverse roles in different pathological conditions. Changing and controlling the phenotypes of macrophages is considered a novel potential therapeutic intervention. Meanwhile, specific transmembrane proteins anchoring on surface macrophage membrane are relatively conserved, supporting its functional properties, such inflammatory chemotaxis tumor targeting. Thus, series drug delivery systems related to commonly used treat chronic diseases. This review summarizes macrophages-based strategies for diseases, discusses regulation their polarization processes, presents how design apply site-specific targeted vivo based derived receptors. It aims provide better understanding immunoregulation proposes approaches

Language: Английский

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Curcuma Longa: Nutraceutical Use and Association With Nanotechnology

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(22)

Published: May 7, 2024

Curcumin is a natural product found in the rhizome of Curcuma longa (L.) and other spp. As lipophilic molecule, it has greater affinity for polar, non-polar, alkaline, or extremely acidic organic solvents. Several studies indicate that curcumin several benefits human health, example, against degenerative diseases, cancer, infectious diseases. To obtain quality with nutraceutical properties, necessary to know its physicochemical characteristics preserve from cultivation until ingestion by human. However, low solubility leads absorption; this context, nanotechnological systems can contribute increase bioavailability. This review aims highlight important issues all stages goes through: aspects related extraction association nanotechnology. Although process already well established, possible observe more research focused on increasing yield being environmentally friendly. Further, curcumin's absorption notable due characteristics, mainly aqueous solubility. nanotechnology shows be promising an increasingly growing trend because use "Indian solid gold" hope many patients.

Language: Английский

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Recent nanotechnology improvements in Curcumin bioavailability and related applications

Food Bioscience, Journal Year: 2024, Volume and Issue: 61, P. 104660 - 104660

Published: July 2, 2024

Language: Английский

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Curcumin nanopreparations: recent advance in preparation and application

Biomedical Materials, Journal Year: 2024, Volume and Issue: 19(5), P. 052009 - 052009

Published: Aug. 27, 2024

Abstract Curcumin is a natural polyphenolic compound extracted from turmeric with antibacterial, antioxidant, antitumor, preventive and therapeutic neurological disorders variety of bioactivities, which widely used in the field food medicine. However, drawbacks curcumin such as poor aqueous solubility stability have limited practical application curcumin. To overcome these defects enhance its functional properties, various nanoscale systems (liposomes, polymer nanoparticles, protein solid lipid metal etc) been extensively employed for encapsulation delivery. Despite rapid development nanoformulations, there lack comprehensive reviews on their preparation properties. This review provides an overview construction nano-delivery systems, mechanisms action, nanocarrier methods applications nanocarriers pharmaceutical fields to provide theoretical basis technological support efficient bio-utilization, product early clinical

Language: Английский

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Curcumin nanocrystals ameliorate ferroptosis of diabetic nephropathy through glutathione peroxidase 4

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 6, 2025

The aim of this study was to investigate the effect curcumin nanocrystals (Cur-NCs) on ferroptosis in high-glucose (HG)-induced HK-2 cells and streptozotocin (STZ)-induced diabetic nephropathy model (DN) rats. purpose is determine whether Cur NCs can become a promising treatment option for diabetes by reducing ferroptosis. Cur-NCs were prepared using microfluidic technology studied dynamic light scattering transmission electron microscopy. treated with 30 mM HG create renal tubule damage cell model. Then, viability evaluated varying concentrations (0.23, 0.47, 0.94, 1.87, 3.75, 7.5, 15, μg/mL) Cell Counting Kit-8 (CCK-8). Furthermore, vivo experiments carried out roles STZ-induced DN results showed that greatly enhanced levels LDH, MDA, Iron, lipid ROS, apoptosis, NCOA4, TFR-1, while decreasing expression GSH, GPX4, SLC7A11, FTH-1. These effects induced could be attenuated Cur-NCs. also reduced HG-induced decrease viability, as well increase ROS however erastin inhibit their effects. inhibited This demonstrates significantly attenuate recovering implying may therapy DN.

Language: Английский

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Development of Nutraceutical and Nutritional Design Method for Liposomal Curcumin and Vitamin C Using Microstructural and Elemental Analysis

Kemija u industriji, Journal Year: 2025, Volume and Issue: 1-2

Published: Jan. 16, 2025

The biomolecular components of curcumin are potent inhibiting nutraceuticals with hydrophobic characteristics.Vitamin C, a water-soluble antioxidant, plays crucial role in strengthening the body's immune system.Liposomal encapsulation enhances solubility and bioactivity curcumin, while also increasing bioavailability vitamin C. In this study, functional nutraceutical nutritional design method was developed using structural elemental analysis prepared liposomal curcumin-vitamin C nanoparticles, utilising scanning electron microscopy.The microstructural images nanoparticles revealed their nature adequate model.The displayed solid surface spherical particles dried forms.The peak patterns graph data constituents samples indicated high levels carbon oxygen, showed as well minerals Mg, P, K.

Language: Английский

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