Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Aseptic inflammation and osteolysis triggered by the phagocytosis of implant wear particles macrophages are important reasons for aseptic loosening (AL) in total joint replacement, which ultimately leads to failure.
Language: Английский
BioNanoScience, Journal Year: 2025, Volume and Issue: 15(1)
Published: Jan. 28, 2025
Language: Английский
Citations
0
Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(2), P. 181 - 181
Published: Feb. 1, 2025
Background/Objectives: Oral mucositis (OM) is a common and debilitating side effect of cancer therapy, characterized by ulceration or inflammation the oral mucosa. This study evaluates preclinical efficacy curcumin-loaded bicosome systems (cur-BS) in mitigating chemotherapy-induced OM mice. Methods: BS were prepared using combination 1,2-di-palmitoyl-sn-glycero-3-phosphocholine (DPPC) 1,2-dihexanoyl-sn-glycero-3-phosphocholine (DHPC), α-tocopherol, curcumin, encapsulated within liposomal vesicles. Three formulations with different curcumin concentrations (180, 540, 900 μM) particle size, polydispersity index (PDI), encapsulation efficiency (EE), appearance, morphology. The formulation highest concentration (cur-BS 5×) was selected for ex vivo permeability studies, release profile analysis, vitro anti-inflammatory efficacy. induced mice 5-fluorouracil (5-FU) acetic acid. Cur-BS 5× compared to commercial product Dentoxol®. Results: results showed that cur-BS provided sustained through mechanism involving both diffusion matrix relaxation, enhancing retention deeper skin layers. Treatment downregulated expression inflammatory markers (IL-1β TNF-α). Macroscopic assessments demonstrated Dentoxol® reduced severity, greatest improvement observed between days 6 9. By day 24, scores 1.25 ± 0.5 1.0 0.0 Dentoxol®, indicating effectiveness treatments. However, histological analysis revealed superior tissue recovery 5×, showing better epithelial structure inflammation. 5×-treated also exhibited greater weight higher survival rates group. Conclusions: These findings suggest may enhance treatment, offering outcomes comparable than those
Language: Английский
Citations
0
Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16
Published: March 17, 2025
Curcumin, a polyphenolic compound derived from the traditional Chinese medicine turmeric, which has variety of pharmacological effects, including anti-cancer, anti-inflammatory, antioxidant, and antiviral properties. However, its clinical application is hindered by low solubility bioavailability. To overcome these limitations, researchers have developed various formulations such as nanoformulations, solid dispersions, microspheres. These advancements led to improved therapeutic effects facilitated progression research, primarily focusing on Phase I II trials for conditions like diabetes, obesity, metabolic syndrome. In recent years, there been noticeable increase in III IV trials, particularly concerning oral dental diseases arthritis. This article reviews literature both domestic international sources, providing comprehensive overview curcumin's research progress, mechanisms, formulation developments, studies.
Language: Английский
Citations
0
Cellular Signalling, Journal Year: 2025, Volume and Issue: unknown, P. 111758 - 111758
Published: March 1, 2025
Language: Английский
Citations
0
Current Pharmacology Reports, Journal Year: 2025, Volume and Issue: 11(1)
Published: April 2, 2025
Language: Английский
Citations
0
Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106908 - 106908
Published: April 1, 2025
Language: Английский
Citations
0
Colloid & Polymer Science, Journal Year: 2025, Volume and Issue: unknown
Published: April 14, 2025
Language: Английский
Citations
0
ACS Applied Bio Materials, Journal Year: 2023, Volume and Issue: 6(12), P. 5864 - 5873
Published: Dec. 4, 2023
To improve the permeation of curcumin, we prepared curcumin-based ionic liquid (Cur-Bet-IL) (IL formed using curcumin succinic anhydride and betaine) from by combining theoretical calculation experimental research then liposome (Cur-Bet-IL-Lip). The Cur-Bet-IL-Lip has good stability (stored for 10 days without significant changes) biocompatibility, which encompasses not only properties but also characteristics liquids liposomes. can penetrate stratum corneum deliver to epidermis dermis skin, cumulative permeability after 24 h was 49%. Compared Cur-Bet-IL, a uptake ability on human immortalized keratinocyte (HaCaT) cells (1.87-fold), reduce expression TNF-α (1.59-fold), IL-1β (1.19-fold), IL-17A (1.53-fold), IL-17F (1.18-fold), IL-22 (1.49-fold) in HaCaT increase collagen-I (1.14-fold). Therefore, guiding significance improving solubility insoluble drugs, provides potential value clinical application curcumin.
Language: Английский
Citations
8
Tribology International, Journal Year: 2023, Volume and Issue: 190, P. 109026 - 109026
Published: Oct. 14, 2023
Language: Английский
Citations
7
International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 5721 - 5737
Published: June 1, 2024
Purpose: Curcumin nanocrystals (Cur-NCs) were prepared by hot melt extrusion (HME) technology to improve the dissolution and bioavailability of curcumin (Cur). Methods: Cur-NCs with different drug-carrier ratios one-step process Eudragit ® EPO (EEP) as carrier. The dispersed size solid state Cur in extruded samples characterized dynamic light scattering (DLS), scanning electron microscope (SEM), differential calorimetry (DSC), X-ray diffraction (XRD). thermal stability was analyzed thermogravimetric analysis (TGA) high performance liquid chromatography (HPLC). Dissolution pharmacokinetics studied evaluate improvement absorption nano-preparation. Results: particle sizes range 50~150 nm successfully using 1:1, 2:1 4:1, crystal form Form 1 both before after HME. extrudate powders showed very efficient cumulative percentage 80% less than 2 min, intrinsic rates them 13.68 ± 1.20 mg/min/cm , 11.78 0.57 4.35 0.20 respectively, whereas that pure only 0.04 0.00 . TGA data demonstrated degradation temperature about 250 °C, while HPLC results degraded when at over 150 °C. Pharmacokinetic experiment a significant Cur. C max Cur-NC group 1.68 times group, area under curve (AUC 0-∞ ) metabolites 2.79 4.07 compared group. Conclusion: can be HME one step, which significantly improves Such novel method for preparing insoluble drug has broad application prospects. Keywords: technology, curcumin, nanocrystals, dissolution, vivo
Language: Английский
Citations
2