Trends in Food Science & Technology, Journal Year: 2024, Volume and Issue: 148, P. 104410 - 104410
Published: April 7, 2024
Language: Английский
Citations
18Gallic Acid Attenuates Sepsis‐Induced Liver Injury through C/EBPβ‐Dependent MAPK Signaling Pathway
Molecular Nutrition & Food Research, Journal Year: 2024, Volume and Issue: 68(11)
Published: May 29, 2024
Liver injury is a major complication associated with sepsis. Together others, the study has shown that gallic acid (GA) exerts anti-inflammatory and antioxidant effects in vivo. However, role of GA sepsis-mediated hepatic impairment underlying mechanisms remains to be elucidated.
Language: Английский
Citations
5Assessing the Potential of Gallic Acid and Methyl Gallate to Enhance the Efficacy of β-Lactam Antibiotics against Methicillin-Resistant Staphylococcus aureus by Targeting β-Lactamase: In Silico and In Vitro Studies
Antibiotics, Journal Year: 2023, Volume and Issue: 12(11), P. 1622 - 1622
Published: Nov. 13, 2023
Methicillin-resistant Staphylococcus aureus (MRSA), a global health concern, has prompted research into antibiotic adjuvants as potential solution. Although our group previously reported the enhancing effects of gallic acid (GA) and methyl gallate (MG) on penicillin G activity against MRSA, synergistic with other β-lactam antibiotics underlying mechanism have not been fully explored. Therefore, this study primarily aimed to investigate antibacterial synergism through disc diffusion, checkerboard, time–kill assays. The β-lactamase inhibition was also examined both molecular modeling in vitro experiments. Additionally, bacterial morphology changes were studied using scanning electron microscopy (SEM). results revealed that GA MG exhibited anti-MRSA showed indifferent when combined methicillin susceptible S. (MSSA). Interestingly, demonstrated only β-lactamase-unstable MRSA lowest fractional inhibitory concentration (FIC) indexes ≤3.75. However, weak inhibition. Furthermore, GA, MG, combination ampicillin induced morphological suggesting possible affecting cell membrane. These findings suggest could potentially serve an adjunct combat infections.
Language: Английский
Citations
11The active ingredients in Chinese peony pods synergize with antibiotics to inhibit MRSA growth and biofilm formation
Microbiological Research, Journal Year: 2024, Volume and Issue: 281, P. 127625 - 127625
Published: Jan. 21, 2024
Language: Английский
Citations
4Livogrit Mitigates ANIT-Induced Cholestasis-Like Symptoms in an In Vivo model by Curbing Hepatic Inflammation and Regulating BAX, TGF-β, MMP-9 and α-SMA Gene Expression
Heliyon, Journal Year: 2025, Volume and Issue: 11(3), P. e41855 - e41855
Published: Jan. 11, 2025
Bile duct constriction disrupts bile acid flow causing cholestasis, hepatic necrosis, fibrosis, and cirrhosis. The study investigated hepatoprotective effectiveness of Ayurvedic prescription herbal medicine "Livogrit" commercially available in India, against α-naphtylisothiocyanate (ANIT)-induced cholestasis-like symptoms male Sprague-Dawley rats. Livogrits's phytochemical profiling showed the presence Gallic acid, Methyl Gallate, Catechin, Corilagin, Ellagic Rutin, Cinnamic acid. rats were pre-treated with Livogrit (20-600 mg/kg/day) reference drug Ursodeoxycholic (100 for 15 5 days, respectively, before single-dose ANIT mg/kg) stimulation. treatment protect ANIT-induced increase blood serum markers (total acids, ALT, AST, GGT, ALP, total cholesterol, bilirubin) reduced manifestation liver inflammation, periportal fibrosis. At molecular level, inhibited up-regulation BAX, TGF-β, α-SMA, MMP-9 mRNA expressions, associated damages. Taken together, this supported Livogrit's potential as cholestasis-like-etiologies.
Language: Английский
Citations
0Quercus infectoria galls mitigates colitis in mice through alleviating mucosal barrier impairment and suppressing inflammatory factors
Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: 343, P. 119487 - 119487
Published: Feb. 13, 2025
Language: Английский
Citations
0Anti-inflammatory effects of Rhus javanica ethanol extract for pulmonary and colonic disorders
Phytomedicine, Journal Year: 2025, Volume and Issue: 139, P. 156535 - 156535
Published: Feb. 17, 2025
Language: Английский
Citations
0Screening of phenolic antibacterial compounds for the prevention of biofouling
Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: 1334, P. 141774 - 141774
Published: Feb. 24, 2025
Language: Английский
Citations
0Bioactivity and biomedical applications of pomegranate peel extract: a comprehensive review
Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16
Published: March 26, 2025
Pomegranate peel is a by-product generated during the processing of pomegranate ( Punica granatum L.) fruit, accounting for approximately 50% total mass fruit. Although usually regarded as waste, it rich in various bioactive metabolites such polyphenols, tannins, and flavonoids, demonstrating significant medicinal nutritional value. In recent years, extract (PPE) has shown broad application prospects biomedical field due to its multiple effects, including antioxidant, anti-inflammatory, antibacterial, anti-apoptotic properties, promotion cell regeneration. This review consolidates major PPE explores applications materials, nanodrug carriers, hydrogels, tissue engineering scaffolds. By synthesizing existing literature, we delve into potential value biomedicine, challenges currently encountered, future directions research. The aim this provide scientific basis optimizing utilization facilitate broader field.
Language: Английский
Citations
0In silico docking, ADMET profiling, and bio-accessibility experimentation on Breynia retusa phytocompounds and in vitro validation for anti-proliferative potencies against ovarian carcinoma
3 Biotech, Journal Year: 2025, Volume and Issue: 15(5)
Published: April 10, 2025
Language: Английский
Citations
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