Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15
Published: Dec. 16, 2024
Numerous studies have demonstrated that
Language: Английский
Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16
Published: Feb. 25, 2025
To investigate the relationship between heart failure (HF) and gut microbiota-mediated energy metabolism, to explore role of Shenfu Injection in this process. In study, Adriamycin-induced chronic (CHF) rat model was used randomly divided into blank control group (Normal, n = 9), HF (Model, 12), treatment (SFI, positive drug (TMZ, 9). The changes microbiota structure were analyzed by 16S rRNA high-throughput sequencing, content short-chain fatty acids (SCFAs) detected targeted metabolomics technology, cardiac function metabolism-related indicators evaluated. Myocardial metabolism rats disordered, characterized reduced acid oxidation, enhanced anaerobic glycolysis glucose, mitochondrial damage, decreased ATP content; imbalanced, with a reduction beneficial bacteria, an increase conditional pathogenic impaired intestinal barrier function; Both trimetazidine improved myocardial function, but more significant regulating improving health; production SCFAs from increased, which may be closely related metabolism; SCFAs-producing bacteria Akkermansia Blautia played key development HF, their abundance positively correlated content. treating improve health microbiota, especially Blautia, thereby exerting therapeutic effects. This provides theoretical support for strategies based on microbiota.
Language: Английский
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Phytochemistry Letters, Journal Year: 2025, Volume and Issue: 67, P. 102943 - 102943
Published: March 22, 2025
Language: Английский
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The FASEB Journal, Journal Year: 2025, Volume and Issue: 39(8)
Published: April 15, 2025
ABSTRACT Colorectal cancer (CRC) shows a limited response to programmed death‐ligand 1 (PD‐L1) immunotherapies. Akkermansia muciniphila (AKK) may enhance tumor immunity. This study examines how its Outer Membrane Vesicles (OMVs) and Amuc_1434 influence PD‐L1 expression CD8+ T cell activity in CRC. OMVs were isolated their characteristics examined through transmission electron microscopy Western blotting. was quantified via blot, while proliferation measured using flow cytometry. Cytokine production (interferon‐gamma (IFN‐γ) interleukin‐2 (IL‐2)) evaluated ELISA. A CRC mouse model employed examine impact on growth immune infiltration. In cells, treatment with AKK‐derived (AKK‐OMVs) significantly downregulated ( p < 0.05) markedly increased the levels of IFN‐γ IL‐2 0.01). identified as key protein mediating these effects. vivo, AKK‐OMVs substantially reduced volume 0.01) enhanced infiltration into microenvironment Additionally, AKK‐OMVs‐treated mice showed activation markers within tissue, further indicating antitumor reveals that AKK‐OMVs, particularly those containing Amuc_1434, can modulate potentiate cell‐mediated immunity These findings suggest novel approach overcoming resistance checkpoint inhibitors
Language: Английский
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Advances in molecular oncology, Journal Year: 2025, Volume and Issue: 12(1), P. 31 - 40
Published: April 14, 2025
The study of the role immune system in tumor progression has been ongoing for over a century, starting with Paul Ehrlich’s hypothesis on its limiting development oncological diseases. cancer immunology confirmed this concept and identified mechanisms complex interactions between cells both foreign agents transformed within organism. Macrophages, natural killers, T-lymphocytes play key roles destroying cells. Among them, special attention is given to tumor-associated macrophages. Tumor can modulate macrophage activity, transforming them into immunosuppressive properties that promote angiogenesis extracellular matrix remodeling. As result, largest population macrophages consists an anti-inflammatory/pro-tumor phenotype (M2).Macrophages anti-inflammatory (M1) are characterized by production pro-inflammatory cytokines, reactive oxygen species, strong cytotoxic activity. They directly or indirectly destroy involving other Traditionally, activity considered important mechanism growth, but some cases, it insufficient effective control. Recent data suggest develop defense against cytotoxicity acquire ability overcome it. Moreover, resulting from interaction possess provide growth advantages.This review dedicated describing new pro-tumor function M1 macrophages, traditionally anti-tumor.
Language: Английский
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Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)
Published: April 30, 2025
The human microbiota comprises a diverse microbial ecosystem that significantly impacts health and disease. Among its components, the gut plays crucial role in regulating metabolic, immunologic, inflammatory responses. Dysbiosis, an imbalance composition, has been linked to carcinogenesis through mechanisms such as chronic inflammation, metabolic disturbances, epigenetic modifications, immune system dysregulation. Additionally, dysbiosis influences efficacy toxicity of cancer therapies. Given these associations, there is growing interest leveraging biomarker for detection outcome prediction. Notably, distinct signatures have identified across various types, suggesting their potential diagnostic markers. Furthermore, modulation presents promising avenue improving treatment outcomes strategies antibiotics, prebiotics, probiotics, fecal transplantation, dietary interventions, small-molecule inhibitors, phage therapy. To explore relationships, we conducted comprehensive literature review using Web Science, Scopus, PubMed, MEDLINE, Embase, Google Scholar our primary online databases, focusing on indexed peer-reviewed articles up present year. This aims elucidate development, examine molecular involved, assess impact highlight microbiota-based therapeutic discuss applications management. A deeper understanding intricate interplay between may pave way novel approaches prevention, early detection, optimization.
Language: Английский
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The Microbe, Journal Year: 2024, Volume and Issue: 4, P. 100096 - 100096
Published: June 2, 2024
Cancer poses a significant global health challenge, with 10 million deaths and 19.3 new cases reported annually. This review aims to investigate the emerging field of synbiotics their potential enhance effectiveness cancer therapies. By conducting thorough analysis preclinical clinical studies, this clarifies various mechanisms through which improve efficacy conventional treatments, such as chemotherapy, immunotherapy, surgery, radiotherapy. A search literature on anti-cancer was performed using PubMed database Google Scholar engine find important original research publications. selection, analysis, discussion related English-language papers were conducted. unravels intricate connections between microbiota therapeutics, harnessing power promising strategy treatment outcomes elevate standard care in oncology. Further is required establish long-term safety synbiotics, right ideal prebiotic-probiotic combinations, distinct signatures different types for development future synbiotics.
Language: Английский
Citations
3
iScience, Journal Year: 2024, Volume and Issue: 27(9), P. 110791 - 110791
Published: Aug. 23, 2024
Probiotics typically refer to microorganisms that have been identified for their health benefits, and they are added foods or supplements promote the of host. A growing number probiotic strains lately developed into valuable regulatory pharmaceuticals nutritional medical applications. Gene editing technologies play a crucial role in addressing need safe therapeutic probiotics disease treatment. These offer assistance comprehending underlying mechanisms bioactivity development advanced probiotics. This review aims comprehensive overview gene applied engineering both traditional next-generation It further explores potential on-demand production customized products derived from enhanced probiotics, with particular emphasis on future live biotherapeutics.
Language: Английский
Citations
3
Journal of Neuroimmune Pharmacology, Journal Year: 2024, Volume and Issue: 19(1)
Published: Aug. 14, 2024
Language: Английский
Citations
2
World Journal of Microbiology and Biotechnology, Journal Year: 2024, Volume and Issue: 40(10)
Published: Sept. 9, 2024
Language: Английский
Citations
1
Modern medical technology, Journal Year: 2024, Volume and Issue: 16(2), P. 132 - 143
Published: June 18, 2024
The aim is to observe and compare the main factors that can improve gut microbiota composition. Materials methods. literature study research was performed in PubMed Google Scholar electronic databases. We assessed more than 300 studies, data from 65 of which were included this review. They are presented three tables: nonpharmacological influence on composition, drugs impact microbiota, medicines prescribed for correction. Results. On one hand, non-pharmacological methods improvement safest most traditional: healthy diet physical activity, good sleep, avoiding stress bad habits, but they difficult patients’ fulfillment doctors’ observation. All listed components a way life should be followed by everybody. have significant so physicians consider their effects prescriptions. antibiotics, steroids non-steroids, proton pump inhibitors, laxatives, antidepressants, etc. other despite diversity available (prebiotics, probiotics, paraprobiotics, postbiotics, synbiotics, antibiotics) used improvement, all them under investigation need further evaluation. trendiest today paraprobiotics postbiotics. Paraprobiotics represented heat / ultraviolet sonication Lactobacillus spp., Bifidobacterium Saccharomyces strains. Postbiotics short-chain fatty acids, secreted biosurfactants, proteins, organic amino bacteriocins, vitamins, peptides. Most pharmacodynamics based animal studies or experimental research, investigations. Fecal transplantation also an up-to-date method multiple disease correction approved only treatment recurrent refractory infections caused Clostridium difficile. Conclusions. Gut composition topic practical medicine because changes closely linked with host health status. violations lead metabolic, cardiovascular, neurological, inflammatory disorders, Nowadays best method, prebiotics, antibiotics supplementation, fecal take place indisputable advantages special cases. Unfortunately, pharmacological modulation weak evidence base. Therefore, question needs appropriate patient groups long-term monitoring.
Language: Английский
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