Transcriptome-based network analysis related to histone deacetylase genes and identified EMP1 as a potential biomarker for prognosis in bladder cancer DOI

Bao Qiong,

Yan Li, Yu Chen

et al.

Clinical Genitourinary Cancer, Journal Year: 2024, Volume and Issue: 23(1), P. 102262 - 102262

Published: Nov. 1, 2024

Language: Английский

Anticancer properties of histone deacetylase inhibitors – what is their potential? DOI
Kajetan Kiełbowski, Agata Szwedkowicz,

Paulina Plewa

et al.

Expert Review of Anticancer Therapy, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 16

Published: Jan. 10, 2025

Introduction Histone modifications are crucial epigenetic mechanisms for regulating gene expression. acetyltransferases and deacetylases (HDACs) catalyze histone acetylation, a process that mediates transcription. Over recent decades, studies have demonstrated targeting acetylation can be effective in cancer treatment, leading to the development approval of several HDAC inhibitors.

Language: Английский

Citations

1
Identification and validation of immune-related gene signature models for predicting prognosis and immunotherapy response in hepatocellular carcinoma DOI Creative Commons
Zhiqiang Liu, Lingge Yang, Chun Liu

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: June 12, 2024

This study seeks to enhance the accuracy and efficiency of clinical diagnosis therapeutic decision-making in hepatocellular carcinoma (HCC), as well optimize assessment immunotherapy response.

Language: Английский

Citations

5
Hydroxamic and Poly(hydroxamic acids): A State-of-the-Art Review of Their Multifaceted Applications DOI

Rawda Maen Sunoqrot,

Mohamad Hamdi Zainal-Abidin, Chen Qian

et al.

Materials Today Communications, Journal Year: 2025, Volume and Issue: unknown, P. 111751 - 111751

Published: Jan. 1, 2025

Language: Английский

Citations

0
Targeting immune cells in tumor microenvironment in triple negative breast cancer therapy: future perspective to overcome doxorubicin resistance and toxicity DOI
Dewajani Purnomosari, Bilqis Zahra Nabila, Sitarina Widyarini

et al.

Medical Oncology, Journal Year: 2025, Volume and Issue: 42(5)

Published: April 4, 2025

Language: Английский

Citations

0
Twist1 Regulates the Immune Checkpoint VISTA and Promotes the Proliferation, Migration and Progression of Pancreatic Cancer Cells DOI Creative Commons
Kübra Sena Baş Topcu, Ercan Çaçan

Journal of Cellular and Molecular Medicine, Journal Year: 2025, Volume and Issue: 29(9)

Published: May 1, 2025

ABSTRACT Pancreatic cancer is one of the deadliest malignant tumours worldwide. Despite developments in treatments pancreatic cancer, survival rates remain at a low level, and mechanisms underlying aggressive course are not fully understood. VISTA an immune checkpoint has recently become significant target treatment; however, roles development have largely remained unknown. Histone deacetylase inhibitors (HDACi) been reported to reverse epithelial‐mesenchymal transition (EMT) may enhance efficacy anti‐PD‐1 therapy. The PD‐L1/PD‐1 targeted by this therapy shares structural similarity with VISTA. Moreover, combination vorinostat shown significantly reduce tumour growth suppressing transcription factor c‐Myc. Therefore, study, we aim investigate genes that associated EMT explore potential mechanism involving Twist1, proto‐oncogene, cancer. We also sought determine synergistic effects HDACi, vorinostat, Twist1‐siRNA on expression cells’ viability proliferation. Our results revealed Twist1 blockade cells suppresses EMT‐associated compared administered alone. As result, identifying understanding role process crucial step contribute identification new targets for treatment improvement existing strategies.

Language: Английский

Citations

0
Caffeic acid inhibits the tumorigenicity of triple-negative breast cancer cells through the FOXO1/FIS pathway DOI Open Access

Chufei Xie,

Liujia Chan,

Yuheng Pang

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 178, P. 117158 - 117158

Published: July 22, 2024

Language: Английский

Citations

3
BET degrader exhibits lower antiproliferative activity than its inhibitor via EGR1 recruiting septins to promote E2F1-3 transcription in triple-negative breast cancer DOI Creative Commons
Nan Liu, Shuai Wang,

M.C. Li

et al.

Pharmacological Research, Journal Year: 2024, Volume and Issue: 208, P. 107377 - 107377

Published: Aug. 28, 2024

The bromodomain and extraterminal domain (BET) family proteins serve as primary readers of acetylated lysine residues play crucial roles in cell proliferation differentiation. Dysregulation BET has been implicated tumorigenesis, making them important therapeutic targets. BET-bromodomain (BD) inhibitors BET-targeting degraders have developed to inhibit proteins. In this study, we found that the inhibitor MS645 exhibited superior antiproliferative activity than including ARV771, AT1, MZ1 dBET1 triple-negative breast cancer (TNBC) cells. Treatment with led dissociation BETs, MED1 RNA polymerase II from E2F1-3 promoter, resulting suppression transcription subsequent inhibition growth TNBC. contrast, while ARV771 displaced chromatin, it did not significantly alter expression. Mechanistically, induced BRD4 depletion at protein level, which markedly increased EGR1 This elevation subsequently recruited septin 2 9 promoters, enhancing promoting rate vitro vivo. Our findings provide valuable insights into differential mechanisms highlight potential developing molecules strategies for

Language: Английский

Citations

2
New Carrageenan/2-Dimethyl Aminoethyl Methacrylate/Gelatin/ZnO Nanocomposite as a Localized Drug Delivery System with Synergistic Biomedical Applications DOI Open Access
Abeer A. Ageeli, Sahera F. Mohamed

Processes, Journal Year: 2024, Volume and Issue: 12(12), P. 2702 - 2702

Published: Nov. 30, 2024

In recent years, the development of multifunctional hydrogels has gained significant attention due to their potential in various biomedical applications, including antimicrobial, antioxidant, and anticancer therapies. By integrating biocompatible polymers nanoparticles, these can achieve enhanced activity targeted therapeutic effects. this study, carrageenan/2-dimethyl aminoethyl methacrylate/gelatin (CAR/DEMA/Gelt) composite hydrogel was synthesized using microwave radiation specifically for its efficiency enhancing cross-linking promoting uniform nanoparticle dispersion within matrix. Zinc oxide (ZnO) nanoparticles were incorporated into form (CAR/DEMA/Gelt/ZnO) nanocomposite. The characterized FT-IR, FE-SEM, XRD, TGA, EDX, confirming successful structural integrity. nanocomposite exhibited more antimicrobial than against Gram-positive Staphylococcus aureus (S. aureus) Bacillus subtilis (B. subtilis), with inhibition zones 15 mm 16 mm, respectively, while case Gram-negative bacteria, Klebsiella pneumoniae (K. pneumoniae) Escherichia coli (E. coli), 29 19 respectively. addition unicellular fungi, Candida albicans (C. albicans), zone mm. Moreover, showed anti-inflammatory comparable those Indomethacin antioxidant activity, an impressive IC50 value 33.3 ± 0.05 µg/mL. vitro cytotoxicity assays revealed activity. Against MCF-7 breast cancer cell line, CAR/DEMA/Gelt/ZnO 72.5 0.02% viability, which decreased 30.8 0.01% after loading doxorubicin (DOX). Similarly, HepG2 liver free displayed 59.9 0.006% depleted 29.9 0.005% when DOX uploaded. This demonstrates strong as a platform particularly therapy.

Language: Английский

Citations

1
Transcriptome-based network analysis related to histone deacetylase genes and identified EMP1 as a potential biomarker for prognosis in bladder cancer DOI

Bao Qiong,

Yan Li, Yu Chen

et al.

Clinical Genitourinary Cancer, Journal Year: 2024, Volume and Issue: 23(1), P. 102262 - 102262

Published: Nov. 1, 2024

Language: Английский

Citations

0