The Metabolic Syndrome: An Overview and Proposed Mechanisms DOI Creative Commons
Fernanda Santos Thomaz, Oliver D. John,

Payel Sinha

et al.

Obesities, Journal Year: 2024, Volume and Issue: 4(3), P. 226 - 255

Published: July 22, 2024

Obesity has emerged as a major public health challenge in the 21st century, contributing to rising prevalence of metabolic syndrome (MetS), cluster interrelated risk factors. These factors include obesity or abdominal obesity, type 2 diabetes mellitus (T2DM), hypertension (HTN), and dyslipidaemia. In this review, we will explore important aspects regulation dynamics lipoprotein metabolism see how they underlie each these risks. Additionally, highlight role ferroptosis, an iron-dependent regulated cell death process, relation inflammatory responses its critical contribution pathophysiology MetS. inflammasome activation, lipotoxicity, influence adipocytokines, adipose tissue macrophages. By exploring interconnections, review aims provide insights into crosstalk, outline pathological mechanisms occurring, identify potential therapeutic targets for managing preventing progression

Language: Английский

SIRT1: Harnessing multiple pathways to hinder NAFLD DOI Creative Commons
Cheng Tian, Rongrong Huang, Ming Xiang

et al.

Pharmacological Research, Journal Year: 2024, Volume and Issue: 203, P. 107155 - 107155

Published: March 23, 2024

Non-alcoholic fatty liver disease (NAFLD) encompasses hepatic steatosis, non-alcoholic steatohepatitis (NASH), fibrosis, cirrhosis, and hepatocellular carcinoma. It is the primary cause of chronic disorders, with a high prevalence but no approved treatment. Therefore, it indispensable to find trustworthy therapy for NAFLD. Recently, mounting evidence illustrates that Sirtuin 1 (SIRT1) strongly associated SIRT1 activation or overexpression attenuate NAFLD, while deficiency aggravates Besides, an array therapeutic agents, including natural compounds, synthetic traditional Chinese medicine formula, stem cell transplantation, alleviates NALFD via upregulation. Mechanically, NAFLD by reestablishing autophagy, enhancing mitochondrial function, suppressing oxidative stress, coordinating lipid metabolism, as well reducing hepatocyte apoptosis inflammation. In this review, we introduced structure function briefly, summarized effect on its mechanism, along application agonists in treating

Language: Английский

Citations

13
Involvement of SIRT1-mediated aging in liver diseases DOI Creative Commons
Yueming Zhang, Chang Gong, Lina Tao

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13

Published: Feb. 20, 2025

Liver disease is a significant global health issue, responsible for millions of deaths annually. Aging, characterized by the gradual decline in cellular and physiological functions, impairs tissue regeneration, increases susceptibility to liver diseases, leads health. Silent information regulator 1 (SIRT1), NAD⁺-dependent deacetylase, has emerged as pivotal factor modulating age-related changes liver. SIRT1 preserves function regulating essential aging-related pathways, including telomere maintenance, epigenetic modifications, senescence, intercellular communication, inflammation, mitochondrial function. Notably, levels naturally with age, contributing progression increased vulnerability injury. This review summarizes regulatory role aging its impact on diseases such fibrosis, alcoholic associated (ALD), metabolic dysfunction-associated steatotic (MASLD), steatohepatitis (MASH), hepatocellular carcinoma (HCC). We also discuss emerging therapeutic approaches, activators, gene therapy, nutritional interventions, which are evaluated their potential restore mitigate progression. Finally, we highlight future research directions optimize SIRT1-targeted therapies clinical applications conditions.

Language: Английский

Citations

1
SIRT1/SIRT3 are robust lysine delactylases and SIRT1-mediated delactylation regulates glycolysis DOI Creative Commons

Runhua Du,

Yanmei Gao,

Cong Yan

et al.

iScience, Journal Year: 2024, Volume and Issue: 27(10), P. 110911 - 110911

Published: Sept. 10, 2024

Language: Английский

Citations

7
Sirt1: An Increasingly Interesting Molecule with a Potential Role in Bone Metabolism and Osteoporosis DOI Creative Commons
Yi Chen,

Hefang Xiao,

Zirui Liu

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(8), P. 970 - 970

Published: Aug. 8, 2024

Osteoporosis (OP) is a common metabolic bone disease characterized by low mass, decreased mineral density, and degradation of tissue microarchitecture. However, our understanding the mechanisms remodeling factors affecting mass remains incomplete. Sirtuin1 (SIRT1) nicotinamide adenine dinucleotide-dependent deacetylase that regulates variety cellular metabolisms, including inflammation, tumorigenesis, metabolism. Recent studies have emphasized important role SIRT1 in homeostasis. This article reviews metabolism OP also discusses therapeutic strategies future research directions for targeting SIRT1.

Language: Английский

Citations

4
Emerging roles of mitochondrial sirtuin SIRT5 in succinylation modification and cancer development DOI Creative Commons
Z. J. Ke, Kaikai Shen, Li Wang

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 29, 2025

Succinylation represents an emerging class of post-translational modifications (PTMs), characterized by the enzymatic or non-enzymatic transfer a negatively charged four-carbon succinyl group to ϵ-amino lysine residues, mediated succinyl-coenzyme A. Recent studies have highlighted involvement succinylation in various diseases, particularly cancer progression. Sirtuin 5 (SIRT5), member sirtuin family, has been extensively studied for its robust desuccinylase activity, alongside deacetylase function. To date, only limited number SIRT5 substrates identified. These mediate diverse physiological processes such as glucose oxidation, fatty acid ammonia detoxification, reactive oxygen species scavenging, anti-apoptosis, and inflammatory responses. The regulation these activities can occur through either same activity acting on different distinct targeting substrate. Aberrant expression closely linked tumorigenesis disease progression; however, role remains controversial. exhibits dual functionalities: it promote tumor proliferation, metastasis, drug resistance, metabolic reprogramming, thereby oncogene; conversely, also inhibit cell growth induce apoptosis, functioning suppressor gene. This review aims provide comprehensive overview current research status SIRT5. We discuss structural characteristics regulatory mechanisms, compare functions with other family members, elucidate mechanisms regulating activity. Specifically, we focus modification progression, highlighting how desuccinylation modulates development delineating underlying involved.

Language: Английский

Citations

0
α‐Lipoic Acid Ameliorates Arsenic‐Induced Lipid Disorders by Promoting Peroxisomal β‐Oxidation and Reducing Lipophagy in Chicken Hepatocyte DOI Creative Commons
Yangfei Zhao, Mingyue Guo,

Ting Pei

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 30, 2025

Abstract Liver disease poses a significant threat to global public health, with arsenic (As) recognized as major environmental toxin contributing liver injury. However, the specific mechanisms and protective effects of α‐lipoic acid (LA) remain unclear. Therefore, this study employs network toxicology pharmacology comprehensively analyze hepatotoxic mechanism As hepatoprotective LA, further verifies peroxisomal β‐oxidation lipophagy in process. The analysis results show that induces damage mainly through autophagy, apoptosis, lipid metabolism, oxidative stress, whereas LA exerts its properties by regulating metabolism. Further verifications find inhibits SIRT1 expression, activates P53 Notch pathways, damages mitochondria, β‐oxidation, increases accumulation, enhances liver, while intervention alleviates As‐induced accumulation targeting SIRT1, ameliorating mitochondrial damage, enhancing thereby alleviating damage. This clarifies hepatotoxicity provides theoretical basis for potential agent.

Language: Английский

Citations

0
Polyguluronate sulfate has potential to mitigate hyperlipidemia by inhibiting the PCSK9-mediated degradation of LDLR DOI
Dan Li,

Meijie Xu,

Dingfu Wang

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 302, P. 140585 - 140585

Published: Feb. 2, 2025

Language: Английский

Citations

0
Metformin delays the decline in thermogenic function of brown adipose tissue in a mouse model of Hutchinson-Gilford progeria syndrome DOI Creative Commons
Xin Xiang,

Yuyue Feng,

Hongcheng Li

et al.

Experimental Gerontology, Journal Year: 2025, Volume and Issue: 201, P. 112702 - 112702

Published: Feb. 6, 2025

Brown adipose tissue (BAT) is the primary site for non-shivering thermogenesis in body and plays a crucial role maintaining core temperature. However, its function gradually declines with age. To mitigate age-related decline BAT thermogenic capacity, we treated progeroid mice metformin to investigate potential mechanisms by which can slow reduction function. We found that mice, after receiving treatment, showed significant improvement senescent state of brown adipocytes through activation SIRT1, effectively reduced mitochondrial oxidative stress. Additionally, slowed UCP1 expression levels tissue, thereby capacity mice. Moreover, inflammatory responses around cells, further improving overall tissue. These findings suggest down aging process targeting enhancing capacity.

Language: Английский

Citations

0
Sirtuin1 in Spinal Cord Injury: Regulatory Mechanisms, Microenvironment Remodeling and Therapeutic Potential DOI Creative Commons
Jinze Li, Shengyu Cui, Yanqiu Li

et al.

CNS Neuroscience & Therapeutics, Journal Year: 2025, Volume and Issue: 31(2)

Published: Feb. 1, 2025

ABSTRACT Background Spinal cord injury (SCI) is a complex central nervous system disorder characterized by multifaceted pathological processes, including inflammation, oxidative stress, programmed cell death, autophagy, and mitochondrial dysfunction. Sirtuin 1 (Sirt1), critical NAD + ‐dependent deacetylase, has emerged as promising therapeutic target for SCI repair due to its potential protect neurons, regulate glial vascular cells, optimize the microenvironment. However, regulatory roles of Sirt1 in are challenging, effects vary depending on activation timing, expression levels, types. Methods A systematic literature review was conducted using PubMed, Scopus, Web Science identify studies investigating SCI. Relevant publications were analyzed synthesize current evidence Sirt1's mechanisms, effects, challenges repair. Results exerts broad across diverse processes types post‐SCI. It promotes neuronal survival axonal regeneration, modulates astrocytes microglia resolve supports oligodendrocyte‐mediated myelination, enhances endothelial function. Proper may mitigate secondary injury, whereas excessive or prolonged could impair inflammatory resolution disrupt cellular homeostasis. This highlights therapies, but include optimizing spatiotemporal addressing dual different Conclusion Targeting represents viable strategy repair, given regulation neuroprotection, immunomodulation, tissue remodeling. translating these findings into therapies requires resolving issues such type‐specific delivery, precise dosage control. provides theoretical foundation practical insights advancing Sirt1‐based treatments

Language: Английский

Citations

0
Effect of time-restricted feeding and caloric restriction in metabolic associated fatty liver disease in male rats DOI Creative Commons

Jiang Deng,

Juan Ma,

Xin Zhang

et al.

Nutrition & Metabolism, Journal Year: 2025, Volume and Issue: 22(1)

Published: Feb. 19, 2025

Language: Английский

Citations

0