Molecular mechanism of mitochondrial autophagy mediating impaired energy metabolism leading to osteoporosis

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2025, Volume and Issue: 1871(3), P. 167685 - 167685

Published: Jan. 20, 2025

Language: Английский

---

The role of the interaction of osteoblasts and osteocytes in vivo and during the process of osteodifferentiation in vitro in the key of further prospects of application for the purposes of regenerative medicine

Translational Medicine, Journal Year: 2025, Volume and Issue: 11(6), P. 532 - 545

Published: Jan. 26, 2025

Pathologies associated with impaired bone homeostasis, including osteoporosis, are among the leading diseases in terms of mortality. The development and implementation tissue engineering approaches based on use human mesenchymal stem cells promises to become a highly effective method for their therapy. However, fundamental cellular mechanism, which is diseases, require an additional study. Interactions between osteoblasts osteocytes undoubtedly plays important role maintaining balance processes formation resorption involved pathogenesis certain diseases. For more in-depth understanding various aspects these interactions, representative model needed. In contrast cell cultures obtained from tissues animal models, employment reflects accurately physiological phenotypical nuances bone. possibility creating systems co-cultivation derived application context translational medicine focus this review.

Language: Английский

---

Decreased sirtuin 1 in type 2 diabetes patients with abnormal BMD

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 29, 2025

Introduction Sirtuin 1, a class III histone deacetylase, plays critical role in the pathophysiology of both diabetes mellitus and bone metabolism by promoting osteoblast differentiation inhibiting osteoclast maturation. However, its exact impact on mineral density (BMD) type 2 (T2DM) remains unclear. This study investigates relationship between 1 levels, BMD, newly diagnosed T2DM patients, specifically examining alterations levels those with concomitant osteoporosis or osteopenia. Methods A total 69 patients 82 control subjects normal glucose tolerance (NGT) were enrolled. Serum turnover markers, including osteocalcin (OC), procollagen N-terminal propeptide (P1NP), β-C-terminal telopeptide I collagen (β-CTX), measured using enzyme-linked immunosorbent assay (ELISA). BMD was assessed via dual-energy X-ray absorptiometry (DXA). Comparisons these parameters made NGT groups. Results further categorized into group (DMn) an osteopenia (DMo), differences subgroups analyzed. Risk factors for osteoporosis/osteopenia also evaluated. found to be significantly diminished relative (P < 0.05), no significant lumbar spine OC, 25(OH)D, β-CTX groups > 0.05). Osteoporosis incidence higher compared controls (34.8% vs. 18.3%, P = 0.026). Subgroup analysis revealed that SIRT1 exhibited reduction Logistic regression indicated age, HDL-C, P1NP, independent risk patients. Discussion In conclusion, decreased serum are associated markers may serve as factor potential biomarker diagnosing disorders

Language: Английский

---

The Sirt1/FOXO signal pathway involves in regulating osteomyelitis progression via modulating mitochondrial dysfunctions and osteogenic differentiation

Journal of Molecular Histology, Journal Year: 2025, Volume and Issue: 56(2)

Published: Feb. 13, 2025

Language: Английский

---