Journal of Diabetes Research,
Journal Year:
2024,
Volume and Issue:
2024(1)
Published: Jan. 1, 2024
Diabetic
liver
injury
is
a
serious
complication
due
to
the
lack
of
effective
treatments
and
unclear
pathogenesis.
Ferroptosis,
form
cell
death
involving
reactive
oxygen
species
(ROS)-dependent
lipid
peroxidation
(LPO),
closely
linked
autophagy
diabetic
complications.
Therefore,
this
study
aimed
at
investigating
role
in
regulating
ferroptosis
by
modulating
degradation
acyl-CoA
synthetase
long-chain
family
member
4
(ACSL4)
hepatocytes
its
potential
impact
on
injury.
Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: Oct. 14, 2024
Iron,
an
essential
mineral
in
the
body,
is
involved
numerous
physiological
processes,
making
maintenance
of
iron
homeostasis
crucial
for
overall
health.
Both
overload
and
deficiency
can
cause
various
disorders
human
diseases.
Ferroptosis,
a
form
cell
death
dependent
on
iron,
characterized
by
extensive
peroxidation
lipids.
Unlike
other
kinds
classical
unprogrammed
death,
ferroptosis
primarily
linked
to
disruptions
metabolism,
lipid
peroxidation,
antioxidant
system
imbalance.
Ferroptosis
regulated
through
transcription,
translation,
post-translational
modifications,
which
affect
cellular
sensitivity
ferroptosis.
Over
past
decade
or
so,
diseases
have
been
as
part
their
etiology,
including
cancers,
metabolic
disorders,
autoimmune
diseases,
central
nervous
cardiovascular
musculoskeletal
Ferroptosis-related
proteins
become
attractive
targets
many
major
that
are
currently
incurable,
some
regulators
shown
therapeutic
effects
clinical
trials
although
further
validation
potential
needed.
Therefore,
in-depth
analysis
its
molecular
mechanisms
may
offer
additional
strategies
prevention
treatment.
In
this
review,
we
discuss
significance
contribution
etiology
development
along
with
evidence
supporting
targeting
approach.
Importantly,
evaluate
recent
promising
interventions,
providing
guidance
future
targeted
treatment
therapies
against
Cardiovascular Diabetology,
Journal Year:
2024,
Volume and Issue:
23(1)
Published: May 9, 2024
Abstract
Dynamin-related
protein
1
(Drp1)
is
a
crucial
regulator
of
mitochondrial
dynamics,
the
overactivation
which
can
lead
to
cardiovascular
disease.
Multiple
distinct
posttranscriptional
modifications
Drp1
have
been
reported,
among
S-nitrosylation
was
recently
introduced.
However,
detailed
regulatory
mechanism
(SNO-Drp1)
in
cardiac
microvascular
dysfunction
diabetes
remains
elusive.
The
present
study
revealed
that
mitogen-activated
kinase
4
(MAP4K4)
consistently
upregulated
diabetic
cardiomyopathy
(DCM)
and
promoted
SNO-Drp1
endothelial
cells
(CMECs),
turn
led
disorder.
Further
studies
confirmed
MAP4K4
at
human
C644
(mouse
C650)
by
inhibiting
glutathione
peroxidase
(GPX4)
expression,
through
stimulated
ferroptosis
diabetes.
In
contrast,
inhibition
via
DMX-5804
significantly
reduced
ferroptosis,
alleviated
improved
db/db
mice
reducing
SNO-Drp1.
parallel,
C650A
mutation
abolished
role
promoting
disorder
dysfunction.
conclusion,
our
findings
demonstrate
plays
an
important
DCM
reveal
activation
may
act
as
downstream
targets,
representing
potential
therapeutic
targets
for
DCM.
Frontiers in Cardiovascular Medicine,
Journal Year:
2025,
Volume and Issue:
11
Published: Jan. 13, 2025
Diabetic
cardiomyopathy
(DCM)
is
one
of
the
most
prevalent
and
severe
complications
associated
with
diabetes
mellitus
(DM).
The
onset
DCM
insidious,
symptoms
being
obvious
only
in
late
stage.
Consequently,
early
diagnosis
a
formidable
challenge
which
significantly
influences
treatment
prognosis
DCM.
Thus,
it
becomes
imperative
to
uncover
innovative
approaches
facilitate
prompt
identification
On
traditional
clinical
side,
we
tend
use
serum
biomarkers
as
well
imaging
common
means
diagnosing
diseases
because
their
convenience
affordability.
As
delve
deeper
into
mechanisms
DCM,
wide
variety
are
becoming
competitive
diagnostic
indicators.
Meanwhile,
application
multiple
techniques
has
also
made
efforts
promote
Besides,
spurt
sequencing
technology
possible
give
hints
about
disease
from
genome
transcriptome,
making
less
difficult,
more
sensitive,
predictive.
Overall,
expected
be
superior
choice
plasma
for
detecting
lesions
at
an
earlier
stage
than
imaging,
its
judicious
utilization
combined
technologies
will
lead
sensitive
future.
Therefore,
this
review
meticulously
consolidates
progress
various
biomarkers,
methods,
realm
diagnosis,
aim
furnishing
novel
theoretical
foundation
guide
future
research
endeavors
towards
enhancing
therapeutic
landscape
Cardiovascular Diabetology,
Journal Year:
2025,
Volume and Issue:
24(1)
Published: Feb. 7, 2025
Cardiovascular
diseases
represent
the
principal
cause
of
death
and
comorbidity
among
people
with
diabetes.
Ferroptosis,
an
iron-dependent
non-apoptotic
regulated
cellular
characterized
by
lipid
peroxidation,
is
involved
in
pathogenesis
diabetic
cardiovascular
diseases.
The
susceptibility
to
ferroptosis
hearts
possibly
related
myocardial
iron
accumulation,
abnormal
metabolism
excess
oxidative
stress
under
hyperglycemia
conditions.
Accumulating
evidence
suggests
can
be
therapeutic
target
for
This
review
summarizes
ferroptosis-related
mechanisms
novel
choices
targeting
pathways.
Further
study
on
ferroptosis-mediated
cardiac
injury
enhance
our
understanding
pathophysiology
provide
more
potential
choices.
International Journal of Drug Discovery and Pharmacology,
Journal Year:
2025,
Volume and Issue:
unknown, P. 100004 - 100004
Published: Feb. 14, 2025
Review
Coronary
Microvascular
Dysfunction:
A
Potential
Intervention
Strategy
against
Acute
Myocardial
Infarction
Zihan
Wang
1,
Lianhua
Fang
Yang
Lv
2,
Shoubao
1,*,
and
Guanhua
Du
1,*
1
Beijing
Key
Laboratory
of
Drug
Targets
Identification
Screening,
Institute
Materia
Medica,
Chinese
Academy
Medical
Sciences
&
Peking
Union
College,
100050,
China
2
Polymorphic
Drugs,
*
Correspondence:
[email protected]
(S.W.);
[email protected]
(G.D.)
Received:
26
August
2024;
Revised:
11
October
Accepted:
Published:
14
February
2025
Abstract:
Recent
studies
have
illuminated
the
role
coronary
microvascular
dysfunction
(CMD)
as
a
pivotal
contributor
to
acute
myocardial
infarction
(AMI).
may
lead
severe
results
including
obstruction
(MVO)
intramyocardial
hemorrhage
(IMH),
which
are
associated
with
poor
prognosis.
This
article
reviews
current
research
on
in
reperfusion
mechanisms,
methods
models
assessing
CMD.
review
emphasizes
importance
CMD
proposes
potential
avenues
for
future
this
field.
Interventions
pave
way
novel
treatment
strategies
management
Bone Research,
Journal Year:
2025,
Volume and Issue:
13(1)
Published: Feb. 25, 2025
Abstract
The
muscular
system
plays
a
critical
role
in
the
human
body
by
governing
skeletal
movement,
cardiovascular
function,
and
activities
of
digestive
organs.
Additionally,
muscle
tissues
serve
an
endocrine
function
secreting
myogenic
cytokines,
thereby
regulating
metabolism
throughout
entire
body.
Maintaining
requires
iron
homeostasis.
Recent
studies
suggest
that
disruptions
ferroptosis,
form
iron-dependent
cell
death,
are
essential
contributors
to
progression
wide
range
diseases
disorders,
including
sarcopenia,
cardiomyopathy,
amyotrophic
lateral
sclerosis.
Thus,
comprehensive
overview
mechanisms
ferroptosis
these
conditions
is
crucial
for
identifying
potential
therapeutic
targets
developing
new
strategies
disease
treatment
and/or
prevention.
This
review
aims
summarize
recent
advances
understanding
molecular
underlying
context
injury,
as
well
associated
disorders.
Moreover,
we
discuss
within
pathway
possible
managing
Finally,
shed
light
on
current
limitations
future
prospects
interventions
targeting
ferroptosis.
Theranostics,
Journal Year:
2024,
Volume and Issue:
14(15), P. 5826 - 5852
Published: Jan. 1, 2024
Ferroptosis,
an
iron-dependent
form
of
regulated
cell
death,
is
emerging
as
a
crucial
regulator
human
physiology
and
pathology.
Increasing
evidence
showcases
reciprocal
relationship
between
ferroptosis
dysregulated
metabolism,
propagating
pathogenic
vicious
cycle
that
exacerbates
pathology
diseases,
particularly
metabolic
disorders.
Consequently,
there
rapidly
growing
interest
in
developing
ferroptosis-based
therapeutics.
Therefore,
comprehensive
understanding
the
intricate
interplay
metabolism
could
provide
invaluable
resource
for
mechanistic
insight
therapeutic
development.
In
this
review,
we
summarize
important
substances
associated
pathways
initiation
progression,
outline
cascade
responses
disease
development,
overview
roles
mechanisms
introduce
methods
detection,
discuss
perspectives
ferroptosis,
which
collectively
aim
to
illustrate
view
basic,
translational,
clinical
science.
