Bibliometric analysis of tumor-associated macrophages and colorectal cancer DOI Creative Commons
Yadi Gao, Weichen Yuan,

Jiexiang Zhang

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 15, 2024

Abstract Background Colorectal cancer (CRC) progression is closely related to the tumor microenvironment (TME). Tumor-associated macrophages (TAMs), predominant immune cells in TME, facilitate proliferation, invasion, metastasis, angiogenesis, chemoresistance, and immunosuppression CRC.TAMs play significant roles both pathological processes therapeutic strategies of CRC. The mutual mechanisms remain unclear, necessitating an in-depth study relationship between TAMs This paper employs bibliometric methods analyze CRC research literature, aiming assess current trends, evaluate status, forecast future directions emerging topics. Methods Publications from Web Science Core Collection (WOSCC) database were searched January 1, 2001, July 31, 2024. Following establishment specific search criteria for time, publication type, language, analysis data visualization conducted using Microsoft Excel, R software, VOSviewer, CiteSpace. Results included 1218 publications, written by 8,302 authors 61 countries 1,657 institutions, published 427 journals, covering 4,451 keywords citing 65,174 references. During period 2017–2023, number publications increased rapidly. most cited country China. leading institutions Sun Yat Sen University, Zhejiang Chinese Academy Sciences, all located Mantovani, Alberto, was prolific author Humanitas University. primary disciplines molecular, biology, immunology, medicine, genetics. Keyword co-occurrence literature co-citation identified NF-κB (nuclear factor kappa-B), endothelial growth factor, polarization, response, PD-1 blockade, checkpoint inhibitors, metabolism as hotspots trends this field. Conclusion employed comprehensively visualize papers 2001 objective hotspots, development targeting CRC, provide a reference point information establish novel driving force treatment.

Language: Английский

Dual inhibitors of DNMT and HDAC remodels the immune microenvironment of colorectal cancer and enhances the efficacy of anti-PD-L1 therapy DOI Creative Commons

Zhanbo Yang,

Bizhu Chu,

Yao Tu

et al.

Pharmacological Research, Journal Year: 2024, Volume and Issue: 206, P. 107271 - 107271

Published: June 19, 2024

Colorectal cancer is the second most prevalent and deadly worldwide. The emergence of immune checkpoint therapy has provided a revolutionary strategy for treatment solid tumors. However, less than 5 % colorectal patients respond to therapy. Thus, it great scientific significance develop "potentiators" In this study, we found that knocking down different DNMT HDAC isoforms could increase expression IFNs in cells, which can enhance effectiveness Therefore, combined inhibition cloud synergistically effect immunotherapy. We dual inhibitors C02S inhibit tumor growth immunocompetent mice but not immunocompromised nude mice, indicates exerts its antitumor effects through system. Mechanistically, ERVs, generated intracellular levels dsRNA then promotes RIG-I/MDA5-MAVS signaling pathway. Moreover, increased infiltration DCs T cells microenvironment, enhanced efficacy anti-PD-L1 MC38 CT26 model. These results confirmed activate pathway, remodel microenvironment therapy, provides new evidence solutions development "potentiator"

Language: Английский

Citations

6
Modulation of Tumor-Associated Macrophages to Overcome Immune Suppression in the Hepatocellular Carcinoma Microenvironment DOI Open Access
Mahmoud Singer, Zhuoli Zhang, Farshid Dayyani

et al.

Cancers, Journal Year: 2024, Volume and Issue: 17(1), P. 66 - 66

Published: Dec. 29, 2024

Hepatocellular carcinoma (HCC) is a major global health issue characterized by poor prognosis and complex tumor biology. One of the critical components HCC microenvironment (TME) tumor-associated macrophages (TAMs), which play pivotal role in modulating growth, immune evasion, metastasis. Macrophages are divided into two subtypes: pro-inflammatory M1 anti-inflammatory M2, both may exist TME with altered function proportion. The M2 further subdivided four distinct suppressive subsets. TAMs generally counted as M2-like functions that exert significant influence on cancer progression ability tumors to escape surveillance. Their involvement responses via different mechanisms at local systemic levels has made them key target for therapeutic interventions seeking enhance treatment outcomes. How TAMs’ depletion influences primary interest immunotherapies. purpose this review delve recent progress TAM-targeting therapies. We will explore current theories, benefits, challenges associated or inhibition. manuscript concludes future directions potential implications clinical practice.

Language: Английский

Citations

4
The role of macrophages in liver metastasis: mechanisms and therapeutic prospects DOI Creative Commons
Qin Yuan,

Linlin Jia,

Jiahua Yang

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 17, 2025

Metastasis is a hallmark of advanced cancer, and the liver common site for secondary metastasis many tumor cells, including colorectal, pancreatic, gastric, prostate cancers. Macrophages in microenvironment (TME) promote cell through various mechanisms, angiogenesis immunosuppression, play unique role development metastasis. are affected by variety factors. Under conditions hypoxia increased acidity TME, more factors now found to polarization macrophages M2 type, exosomes amino acids. M2-type secretion such as VEGF, IL-1β, TGF-β1. subjected multiple regulatory mechanisms. They also interact with cells within co-regulate certain conditions, creation an immunosuppressive microenvironment. This interaction promotes metastasis, drug resistance, immune escape. Based on advent single-cell sequencing technology, further insights into macrophage subpopulations may help exploring new therapeutic targets future. In this paper, we will focus how affect well other each other, investigate mechanisms involved their potential targets.

Language: Английский

Citations

0
Discovery of Novel Pyrrolo[2,3-b]pyridine-Based CSF-1R Inhibitors with Demonstrated Efficacy against Patient-Derived Colorectal Cancer Organoids DOI
Jinting He, Wenxue Gao, Rongrong Dong

et al.

Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 27, 2025

Repolarizing M2-like tumor associated macrophages (TAMs) into M1 phenotype by blocking CSF-1/CSF-1R signaling pathway represents a promising strategy to remodel the immune microenvironment. Therefore, discovery of novel potent CSF-1R inhibitors is great significance for colorectal cancer immunotherapy. In this work, series were designed and synthesized through rational molecular hybridization step structural optimization based on PLX3397 BLZ945. Among these derivatives, compound III-1 was strongly bound showed inhibitory activity. It also effectively inhibited activation intracellular its downstream events. Mechanically, efficiently repolarized TAMs M1-phenotype, proliferation promoted apoptosis cells immunoregulation. More importantly, demonstrated efficacy against patient-derived organoids exhibited stronger anticolorectal in vivo compared PLX3397, highlighting potential immunotherapy cancer.

Language: Английский

Citations

0
Myeloid cells: key players in tumor microenvironments DOI
Qiaomin Hua, Zhixiong Li, Yulan Weng

et al.

Frontiers of Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: March 6, 2025

Language: Английский

Citations

0
Endoplasmic Reticulum-Targeted Phototherapy Remodels the Tumor Immunopeptidome to Enhance Immunogenic Cell Death and Adaptive Anti-Tumor Immunity DOI Creative Commons
Weidong Xiao,

Mingquan Gao,

Banghui Mo

et al.

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(4), P. 491 - 491

Published: March 28, 2025

Background: Endoplasmic reticulum (ER)-targeted phototherapy has emerged as a promising approach to amplify ER stress, induce immunogenic cell death (ICD), and enhance anti-tumor immunity. However, its impact on the antigenicity of dying tumor cells remains poorly understood. Methods: Laser activation ER-targeted photosensitizer ER-Cy-poNO2 was performed investigate effects antigenicity. Transcriptomic analysis carried out assess gene expression changes. Immunopeptidomics profiling used identify high-affinity major histocompatibility complex class I (MHC-I) ligands. In vitro functional studies were conducted evaluate dendritic maturation T lymphocyte activation, while in vivo experiments by combining identified peptide with poly IC Results: significantly remodeled antigenic landscape 4T-1 cells, enhancing their immunogenicity. revealed upregulation antigen processing presentation pathways. multiple MHC-I ligands, IF4G3986–994 (QGPKTIEQI) showing exceptional vitro, promoted enhanced lymphocytes activation. vivo, combination elicited robust immunity, characterized increased CD8+ infiltration, reduced regulatory (Tregs) microenvironment, elevated systemic Interferon-gamma (IFN-γ) levels, significant growth inhibition without toxicity. Conclusions: These findings establish mechanistic link between stress-driven ICD, immunopeptidome remodeling, adaptive immune highlighting potential platform for identifying peptides advancing peptide-based cancer vaccines.

Language: Английский

Citations

0
Cholesterol effects on the tumor immune microenvironment: from fundamental concepts to mechanisms and implications DOI Creative Commons
Francisco Alejandro Lagunas‐Rangel

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: April 9, 2025

In many cancers, the tumor microenvironment is enriched with cholesterol due to increased biosynthesis and uptake by cancer cells, resulting in accumulation of cholesterol, esters, oxysterols other metabolites various functions. These molecules serve as structural components, energy sources intracellular signaling mediators, while their toxic by-products are secreted suppress anti-tumor immune activity prevent lipid peroxidation that could induce cell apoptosis. Immune cells also contribute dynamics. Tumor-associated macrophages (TAMs) release support metabolism, myeloid-derived suppressor (MDSCs) consume essential such L-arginine, which impairs T-cell proliferation activation. Elevated dendritic migration antigen presentation and, lymphocytes, favors development a regulatory T (Treg) phenotype inhibits antitumor cytokines, further weakening response. findings suggest targeting metabolism promising strategy for treatment, improving efficacy checkpoint blockade (ICB) therapies. this manuscript, molecular mechanisms underlying effects on landscape reviewed potential cholesterol-lowering drugs enhance responses explored.

Language: Английский

Citations

0
Decoding the Neuroimmune Axis in Colorectal Cancer: From Neural Circuitry to Therapeutic Innovation DOI
Ying Li, Suk‐Kyun Yang,

Yongyin Zhang

et al.

Cytokine & Growth Factor Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Cancer Stem Cells and Tumor-Associated Macrophages: Interactions and Therapeutic Opportunities DOI
Haitao Yuan, Yun Qiu,

Zijie Mei

et al.

Cancer Letters, Journal Year: 2025, Volume and Issue: unknown, P. 217737 - 217737

Published: April 1, 2025

Language: Английский

Citations

0
CSF-1R: A promising therapeutic target for various diseases DOI Creative Commons
Chen‐Yueh Wen, Po‐Hung Chen,

Feng-Renn Hsieh

et al.

Pharmacological Research, Journal Year: 2024, Volume and Issue: 204, P. 107196 - 107196

Published: April 25, 2024

Language: Английский

Citations

1