Optimizing cancer treatment: the synergistic potential of CAR-T cell therapy and CRISPR/Cas9

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 8, 2024

Optimizing cancer treatment has become a pivotal goal in modern oncology, with advancements immunotherapy and genetic engineering offering promising avenues. CAR-T cell therapy, revolutionary approach that harnesses the body's own immune cells to target destroy cells, shown remarkable success, particularly treating acute lymphoblastic leukemia (ALL), other hematologic malignancies. While therapy promise, challenges such as high cost manufacturing complexity remain. However, its efficacy solid tumors remains limited. The integration of CRISPR/Cas9 technology, powerful precise genome-editing tool, also raises safety concerns regarding unintended edits off-target effects, offers synergistic potential overcome these limitations. can enhance by improving specificity persistence reducing resistance tumor-induced immunosuppression. This combination facilitate knockout checkpoint inhibitors, boosting anti-tumor activity cells. Recent studies have demonstrated CRISPR/Cas9-edited previously untreatable types, new hope for patients refractory cancers. not only enhances but paves way personalized therapies tailored individual profiles. review highlights ongoing research efforts refine this explores revolutionize across broader range As progresses, holds promise transforming treatment, making it more effective accessible. current advancements, challenges, future prospects innovative therapeutic strategy.

Language: Английский

Tumor microenvironment and immune-related myositis: addressing muscle wasting in cancer immunotherapy

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: May 2, 2025

Cancer immunotherapy, which leverages the immune system to target neoplastic cells, has undergone significant transformation in recent. However, immunotherapy may have negative effects on skeletal muscle function, causing wasting and functional decline cancer patients. In this study, we review mechanisms by influences muscle, focusing immune-related myositis, inflammation, metabolic alterations within tumor microenvironment (TME). The key methodologies, including biomechanical assessment techniques such as electrical impedance myography ultrasound imaging, are discussed provide valuable insights into process that maintain integrity function patients receiving immunotherapy. Moreover, dual of suppression damage described, revealing significance inflammatory cytokines, checkpoints, disturbances TME. Importantly, propose combination therapies integrating nutritional interventions or anti-inflammatory potential approaches for mitigating wasting. This study highlights need deeper investigations optimize improve its efficacy preserving health, thereby improving patient outcomes quality life.

Language: Английский

The role of CD95 in modulating CAR T-cell therapy: Challenges and therapeutic opportunities in oncology

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 144, P. 113675 - 113675

Published: Nov. 27, 2024

Language: Английский