The triangular relationship between traditional Chinese medicines, intestinal flora, and colorectal cancer

Medicinal Research Reviews, Journal Year: 2023, Volume and Issue: 44(2), P. 539 - 567

Published: Sept. 3, 2023

Abstract Over the past decade, colorectal cancer has reported a higher incidence in younger adults and lower mortality rate. Recently, influence of intestinal flora initiation, progression, treatment been extensively studied, as well their positive therapeutic impact on inflammation microenvironment. Historically, traditional Chinese medicine (TCM) widely used via promoted cell apoptosis, inhibited metastasis, reduced drug resistance side effects. The present research is more effect either herbal or cancer. interactions between TCM are bidirectional combined impacts gut microbiota colon should not be neglected. Therefore, this review discusses role bacteria progression by inhibiting carcinogenesis, participating therapy, assisting healing. Then complex anticolon effects different kinds monomers, pairs, prescriptions embodied immune suppression, summarized separately. In addition, interaction were analyzed. This provides mechanistic reference for application clinical paves way development microbiome TCM.

Language: Английский

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Tailoring traditional Chinese medicine in cancer therapy

Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 21, 2025

Language: Английский

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Ischemic stroke and intestinal flora: an insight into brain–gut axis

European journal of medical research, Journal Year: 2022, Volume and Issue: 27(1)

Published: May 25, 2022

Stroke is a type of cerebrovascular disease that significantly endangers human health and lowers quality life. This understandably places heavy burden on society families. In recent years, intestinal flora has attracted increasing attention from scholars worldwide, its association with ischemic stroke becoming hot topic research amongst researchers in field stroke. After suffering stroke, microbial dysbiosis leads to increased permeability activation the immune system, which turn ectopic bacteria pro-inflammatory cells enter brain tissue through damaged blood-brain barrier. exacerbates ischemia-reperfusion injury. Interestingly, after some metabolites produced by attenuate injury suppressing post-stroke inflammatory response promotes repair neurological function. Here we elucidate changes gut occurrence highlight immunomodulatory processes flora.

Language: Английский

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Insight into TLR4 receptor inhibitory activity via QSAR for the treatment of Mycoplasma pneumonia disease

RSC Advances, Journal Year: 2023, Volume and Issue: 13(3), P. 2057 - 2069

Published: Jan. 1, 2023

Mycoplasma pneumoniae (MP) is one of the most common pathogenic organisms causing upper and lower respiratory tract infections, lung injury, even death in young children. Toll-like receptors (TLRs) play an important role innate immunity by allowing host to recognize pathogens invading body. Previous studies demonstrated that TLR4 a potential therapeutic target for treatment MP pneumonia. Therefore, present study aimed screen biologically active ingredients receptor pathway. We first used molecular docking out compounds inhibiting pathway, then regression classification machine learning algorithms establish quantitative structure-activity relationship (QSAR) model predict biological activity screened compounds. A total 78 molecules were QSAR modelling, which retrieved from ChEMBL database. The models had acceptable correlation coefficients R2 on training testing dataset range 0.96 0.91 0.93 0.76, respectively. multiclass showed accuracy data within ranges 1.0 0.70, 0.63, log loss 0.27 8.63, In addition, descriptors fingerprints have been studied as structural elements involved increased decreased inhibitory activities. These results provide analysis applicable high-throughput screening, well insights into mechanisms inhibition antagonists.

Language: Английский

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Oral Administration of Lactobacillus gasseri and Lacticaseibacillus rhamnosus Ameliorates Amyloid Beta (Aβ)-Induced Cognitive Impairment by Improving Synaptic Function Through Regulation of TLR4/Akt Pathway

Antioxidants, Journal Year: 2025, Volume and Issue: 14(2), P. 139 - 139

Published: Jan. 24, 2025

This study investigated the anti-amnesic effects of Lactobacillus gasseri (L. gasseri) MG4247 and Lacticaseibacillus rhamnosus rhamnosus) MG4644 in amyloid beta (Aβ)-induced mice. We confirmed that oral administration L. ameliorated cognitive impairment Aβ-induced mice using Y-maze, passive avoidance, Morris water maze tests. Oral protected antioxidant system by regulating superoxide dismutase levels, reduced glutathione malondialdehyde contents. Similarly, they attenuated mitochondrial function decreasing reactive oxygen species levels increasing membrane potential ATP levels. In addition, regulated neuroinflammation neurotoxicity modulating Toll-like receptor 4 (TLR4)/protein kinase B (Akt) pathway. As a result, enhanced synaptic acetylcholine contents, acetylcholinesterase activity, expression synaptic-function-related proteins such as AChE, ChAT, SYP, PSD-95, GAP-43. Furthermore, improved dysbiosis promoting growth beneficial bacteria while suppressing harmful bacteria. Therefore, these results suggest may be used probiotics to prevent impairment.

Language: Английский

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Gut Microbiota–Tumor Microenvironment Interactions: Mechanisms and Clinical Implications for Immune Checkpoint Inhibitor Efficacy in Cancer

Cancer Management and Research, Journal Year: 2025, Volume and Issue: Volume 17, P. 171 - 192

Published: Jan. 1, 2025

Cancer immunotherapy has transformed cancer treatment in recent years, with immune checkpoint inhibitors (ICIs) emerging as a key therapeutic approach. ICIs work by inhibiting the mechanisms that allow tumors to evade detection. Although have shown promising results, especially solid tumors, patient responses vary widely due multiple intrinsic and extrinsic factors within tumor microenvironment. Emerging evidence suggests gut microbiota plays pivotal role modulating at site may even influence outcomes patients receiving ICIs. This review explores complex interactions between microenvironment, examining how these could impact effectiveness of ICI therapy. Furthermore, we discuss dysbiosis, an imbalance composition, contribute resistance ICIs, highlight microbiota-targeted strategies potentially overcome this challenge. Additionally, studies investigating diagnostic potential profiles patients, considering microbial markers might aid early detection stratification By integrating insights from preclinical clinical studies, aim shed light on microbiome modulation adjunct tool, paving way for personalized approaches optimize outcomes.

Language: Английский

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Chronic stress promotes colorectal cancer progression by enhancing glycolysis through β2-AR/CREB1 signal pathway

International Journal of Biological Sciences, Journal Year: 2023, Volume and Issue: 19(7), P. 2006 - 2020

Published: Jan. 1, 2023

Colorectal cancer (CRC) is a common malignancy worldwide, and chronic stress has been considered as significant risk factor for CRC.However, the role of in CRC progression unclear.The present study showed that pre-exposure to facilitated tumor growth mice, epinephrine promoted cell proliferation vitro.Metabolomics analysis revealed reshaped metabolic pathways enhance glycolysis.Additional studies have shown enhanced expression levels glycolytic-associated enzymes, including GLUT1, HK2 PFKP.Mechanistically, activated β2-AR/PKA/CREB1 pathway, result, phosphorylated CREB1 transcriptional induced glycolytic enzymes expression.Furthermore, stress-induced could be reversed by administration glycolysis inhibitor 2-deoxyglucose (2-DG) β2-AR antagonist ICI118,551, respectively.Altogether, these findings define novel insights into epinephrine-mediated from point view energy metabolism reprogramming provide perspective on targeting potential approach stress-associated treatment.

Language: Английский

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The alteration of gut microbiota in venlafaxine-ameliorated chronic unpredictable mild stress-induced depression in mice

Behavioural Brain Research, Journal Year: 2023, Volume and Issue: 446, P. 114399 - 114399

Published: March 23, 2023

Language: Английский

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Structure-activity relationship, bioactivities, molecular mechanisms, and clinical application of nuciferine on inflammation-related diseases

Pharmacological Research, Journal Year: 2023, Volume and Issue: 193, P. 106820 - 106820

Published: June 12, 2023

Nuciferine aporphine alkaloid mainly exists in Nelumbo nucifera Gaertn and is a beneficial to human health, such as anti-obesity, lowering blood lipid, prevention of diabetes cancer, closely associated with inflammation. Importantly, nuciferine may contribute its bioactivities by exerting intense anti-inflammatory activities multiple models. However, no review has summarized the effect nuciferine. This critically information regarding structure-activity relationships dietary Moreover, biological clinical application on inflammation-related diseases, obesity, diabetes, liver, cardiovascular well their potential mechanisms, involving oxidative stress, metabolic signaling, gut microbiota been reviewed. The current work provides better understanding anti-inflammation properties against thereby improving utilization nuciferine-containing plants across functional food medicine.

Language: Английский

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The interactions between traditional Chinese medicine and gut microbiota in cancers: Current status and future perspectives

Pharmacological Research, Journal Year: 2024, Volume and Issue: 203, P. 107148 - 107148

Published: March 22, 2024

The gut microbiota, known as the "forgotten organ" and "human second genome," comprises a complex microecosystem. It significantly influences development of various tumors, including colorectal, liver, stomach, breast, lung cancers, through both direct indirect mechanisms. These mechanisms include "gut-liver" axis, "lung-intestine" interactions with immune system. intestinal flora exhibits dual roles in cancer, promoting suppressing its progression. Traditional Chinese medicine (TCM) can alter cancer progression by regulating flora. modifies flora's composition structure, along levels endogenous metabolites, thus affecting barrier, system, overall body metabolism. actions contribute to TCM's significant antitumor effects. Moreover, microbiota metabolizes TCM components, enhancing their properties. Therefore, exploring interaction between offers novel perspective understanding This paper succinctly reviews association gastric, cancers. further examines current research on flora, focus efficacy. identifies limitations existing studies suggests recommendations, providing insights into drug effectiveness. Additionally, this aims guide future studies.

Language: Английский

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