Recent advances in polysaccharide-based drug delivery systems for cancer therapy: a comprehensive review

Artificial Cells Nanomedicine and Biotechnology, Journal Year: 2024, Volume and Issue: 52(1), P. 564 - 586

Published: Dec. 5, 2024

Cancer has a high rate of incidence and mortality throughout the world. Although several conventional approaches have been developed for treatment cancer, such as surgery, chemotherapy, radiotherapy thermal therapy, they remarkable disadvantages which result in inefficient cancer. For example, immunogenicity, prolonged treatment, non-specificity, metastasis cost are considered major drawbacks chemotherapy. Therefore, there is fundamental requirement development breakthrough technologies cancer suppression. Polysaccharide-based drug delivery systems (DDSs) most reliable carriers therapy. Polysaccharides, kind practical biomaterials, divided into types, including chitosan, alginates, dextran, hyaluronic acid, cyclodextrin, pectin, etc. Polysaccharides extracted from different natural resources (like herbal, marine, microorganisms, etc.). The potential features polysaccharides made them candidates therapeutics to sites; simple purification, ease modification functionalization, hydrophilicity, serum stability, appropriate loading capacity, biocompatibility, bioavailability, biodegradability stimuli-responsive sustained release manner considerable aspects these biopolymers. This review highlights applications polysaccharides-based DDSs pharmaceutical science

Language: Английский

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Modulatory effects of traditional Chinese medicines on gut microbiota and the microbiota-gut-x axis

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 9, 2024

The gut microbiota offers numerous benefits to the human body, including promotion of nutrient absorption, participation in metabolic processes, and enhancement immune function. Recent studies have introduced concept gut-organ axis, which encompasses interactions such as gut-brain gut-liver gut-lung axis. This underscores complex interplay between various organs tissues, brain, heart, lungs, liver, kidneys, muscles, bones. Growing evidence indicates that can influence onset progression multi-organ system diseases through their effects on Traditional Chinese medicine has demonstrated significant efficacy regulating gastrointestinal system, leveraging its unique advantages. Considerable advancements been made understanding role axis within mechanisms action traditional medicine. review aims elucidate roles health, explore potential connections microbiota, examine therapeutic microbiota-gut-organ Furthermore, addresses limitations challenges present current research while proposing directions for future investigations this area.

Language: Английский

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Rising of natural therapies: Potential and challenges of traditional Chinese medicine in the management of gastrointestinal diseases

World Journal of Gastroenterology, Journal Year: 2025, Volume and Issue: 31(9)

Published: Feb. 18, 2025

In the contemporary medical landscape, burgeoning interest in natural therapies, particularly for managing gastrointestinal disorders, has brought traditional Chinese medicine (TCM) to forefront. This article explains core principles and clinical applications of TCM treating these conditions, furthering discourse through an examination integrated strategies, as demonstrated study by Zhou et al. While shown promising outcomes, it encounters significant hurdles standardization, mechanistic research, validation. Future investigations should aim solidify scientific underpinnings expand its use disease management, striving a seamless fusion practices.

Language: Английский

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Therapeutic Potential of Prunus Species in Gastrointestinal Oncology

Cancers, Journal Year: 2025, Volume and Issue: 17(6), P. 938 - 938

Published: March 10, 2025

Background: Gastrointestinal tract cancers represent a significant worldwide health concern, accounting for almost one-third of cancer-related deaths. The existing chemotherapy drugs used in gastrointestinal are ineffective, so prognosis is poor, recurrence and metastasis rates high, survival time remains short, necessitating the development novel antitumor that exhibit low toxicity less potential drug resistance. This challenge considerable, but evidence from past decades supports medicinal properties functionalities bioactive compounds such as flavonoids acid phenolics with anticancer activities. Our purpose was to find data on relationship between cancer Prunus species, focusing their molecular mechanisms action. Results: Studies highlight species modulate cell signaling pathways involved tumorigenesis. Conclusions: studies reviewed suggest polyphenols promising activities could an adjunctive therapeutic strategy treatment. Further necessary validate these compounds’ feasibility cost-effective treatments cancer.

Language: Английский

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Aromatic Molecular Compatibility Attenuates Influenza Virus-Induced Acute Lung Injury via the Lung–Gut Axis and Lipid Droplet Modulation

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(4), P. 468 - 468

Published: March 26, 2025

Background: Acute lung injury (ALI) is a major cause of death in patients with various viral pneumonias. Our team previously identified four volatile compounds from aromatic Chinese medicines. Based on molecular compatibility theory, we defined their combination as (AC), though its therapeutic effects and underlying mechanisms remain unclear. Methods: This study used influenza A virus (IAV) A/PR/8/34 to construct cell mouse models ALI explore AC’s protective against infection. The effect AC was verified by evaluating the antiviral efficacy models, including improvements colon inflammation, oxidative stress, suppression NLRP3 inflammasome. In addition, 16S rDNA lipid metabolomics were analyze potential AC. Results: vitro vivo studies demonstrated that increased survival IAV-infected cells mice, inhibited replication expression proinflammatory factors tissues, ameliorated barrier damage colonic tissues. ROS inflammasome improved inflammatory infiltration into Finally, effectively regulated intestinal flora disorders metabolism model significantly reduced cholesterol triglyceride expression, thus abnormal accumulation droplets (LDs) after IAV Conclusions: this study, could treat IAV-induced ALIs through multiple pathways, anti-inflammatory pathways modulation LDs.

Language: Английский

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Qingfei mixture mitigates immunosuppression of tumor microenvironment in non-small cell lung cancer by blocking stat1/Ido1-mediated tryptophan-kynurenine pathway

Heliyon, Journal Year: 2024, Volume and Issue: 10(11), P. e32260 - e32260

Published: May 31, 2024

Programmed death-1 (PD-1) acts as a T cell checkpoint and is important in controlling exhaustion. Blocking the intercommunication across PD-1 PD-L1 promising for advanced lung cancer treatment. However, response rate requires being strengthened. This study aimed to determine whether combination treatment of Qingfei mixture (QFM) inhibitor could improve sensitivity monoclonal antibody by regulating STAT1/IDO1-mediated tryptophan (Trp)-kynurenine (Kyn) pathway. The

Language: Английский

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Oleanolic acid 28-O-β-D-glucopyranoside: A novel therapeutic agent against ulcerative colitis via anti-inflammatory, barrier-preservation, and gut microbiota-modulation

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 180, P. 117534 - 117534

Published: Oct. 13, 2024

Language: Английский

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Bacteroides Fragilis Exacerbates T2D Vascular Calcification by Secreting Extracellular Vesicles to Induce M2 Macrophages

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 12, 2024

Abstract Vascular calcification (VC) in type 2 diabetes (T2D) poses a serious threat to the life and health of patients. However, its pathogenesis remains unclear, resulting lack effective treatment for root cause. It is found that both intestinal Bacteroides fragilis (BF) peripheral M2 monocytes/macrophages are significantly elevated patients with T2D VC. macrophages identified as significant risk factor Both BF their extracellular vesicles (EV) promote VC facilitate macrophage polarization. Macrophages clearance antagonized EV‐induced mice. Mechanistically, EV‐rich double‐stranded DNA (dsDNA) activates stimulator interferon response cGAMP interactor 1 (Sting), promotes myocyte enhancer 2D (Mef2d) phosphorylation, upregulates tribbles pseudokinase (Trib1) expression, induces Concurrently, Mef2d activated by EV targets expression pro‐calcification Serpine1, thereby exacerbating Clinical studies have shown Serpine1 blood closely associated In summary, this study reveals Trib1 through EV‐Sting‐Mef2d pathway induce polarization serpin family E member (Serpine1) aggravating The findings provide new theoretical experimental bases optimizing strategies prevention

Language: Английский

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