Neuropsychiatric Disease and Treatment,
Journal Year:
2025,
Volume and Issue:
Volume 21, P. 167 - 183
Published: Jan. 1, 2025
This
systematic
review
with
trial
sequential
analysis
(TSA)
aims
to
evaluate
the
efficacy
and
safety
of
Shu
Mian
Capsule
(SMC),
a
commercial
Chinese
polyherbal
preparation,
for
managing
depression
or
without
comorbid
insomnia.
Controlled
clinical
trials
assessing
SMC
against
waitlist
control,
placebo
active
controls,
as
an
adjunct
treatment
were
searched
across
seven
databases.
Risk
bias
evidence
quality
assessed
using
Cochrane
criteria
GRADE
framework,
respectively.
Fourteen
studies
analyzed,
involving
1207
participants.
Trials
comparing
standard
antidepressive
treatments
limited.
In
depressed
patients
insomnia,
combining
antidepressants
reduced
incidence
antidepressants-induced
sleep
disorders
(from
12.2%
3.8%)
but
did
not
significantly
lower
Hamilton
Rating
Scale
Depression
(HAM-D)
scores
compared
alone
[SMD
=
-0.09,
95%
CI
(-0.32,
0.14),
p
0.45].
combination
psychotropic
drugs
HAM-D
-1.29,
(-1.96,
-0.62),
<
0.01]
Pittsburgh
Sleep
Quality
Index
-1.53,
(-1.95,
-1.11),
0.01],
exhibited
various
drug-related
adverse
effects
alone.
TSA
validated
sample
size
adequacy;
nevertheless,
methodological
supporting
varied
from
very
low
due
substantial
risk.
Additionally,
92.9%
lacked
follow-ups.
The
effectiveness
alternative
conventional
is
unclear.
For
adding
care
demonstrates
augmented
improved
safety,
though
methodologically
Further
rigorous
are
warranted
confirm
SMC's
short-term
explore
its
medium-
long-term
either
complementary
therapy.
Current
precludes
recommendations
administration
in
depression.
Frontiers in Immunology,
Journal Year:
2023,
Volume and Issue:
13
Published: Feb. 2, 2023
Ischemic
stroke
(IS)
is
one
of
the
most
fatal
diseases.
Neuroimmunity,
inflammation,
and
oxidative
stress
play
important
roles
in
various
complex
mechanisms
IS.
In
particular,
early
proinflammatory
response
resulting
from
overactivation
resident
microglia
infiltration
circulating
monocytes
macrophages
brain
after
cerebral
ischemia
leads
to
secondary
injury.
Microglia
are
innate
immune
cells
that
constantly
monitor
microenvironment
under
normal
conditions.
Once
occurs,
activated
produce
dual
effects
neurotoxicity
neuroprotection,
balance
two
determines
fate
damaged
neurons.
The
activation
defined
as
classical
(M1
type)
or
alternative
(M2
type).
M1
type
secrete
pro-inflammatory
cytokines
neurotoxic
mediators
exacerbate
neuronal
damage,
while
M2
promote
a
repairing
anti-inflammatory
response.
Fine
regulation
M1/M2
microglial
minimize
damage
maximize
protection
has
therapeutic
value.
This
review
focuses
on
interaction
between
other
involved
IS
phenotypic
characteristics,
mechanism
natural
plant
components
regulating
IS,
providing
novel
candidate
drugs
for
drug
development.
Frontiers in Immunology,
Journal Year:
2023,
Volume and Issue:
14
Published: Oct. 10, 2023
Adult
hippocampal
neurogenesis
generates
functional
neurons
from
neural
progenitor
cells
in
the
dentate
gyrus
(DG)
to
complement
and
repair
circuits,
thus
benefiting
treatment
of
depression.
Increasing
evidence
has
shown
that
aberrant
microglial
activity
can
disrupt
appropriate
formation
development
properties
neurogenesis,
which
will
play
a
crucial
role
occurrence
However,
mechanisms
crosstalk
between
microglia
adult
depression
are
not
yet
fully
understood.
Therefore,
this
review,
we
first
introduce
recent
discoveries
regarding
roles
etiology
Then,
systematically
discuss
possible
how
regulate
according
studies,
involve
toll-like
receptors,
polarization,
fractalkine-C-X3-C
motif
chemokine
receptor
1,
hypothalamic-pituitary-adrenal
axis,
cytokines,
brain-derived
neurotrophic
factor,
microbiota-gut-brain
etc.
In
addition,
summarize
promising
drugs
could
improve
by
regulating
microglia.
These
findings
help
us
understand
complicated
pathological
shed
light
on
new
strategies
for
disease.
Behavioural Brain Research,
Journal Year:
2021,
Volume and Issue:
420, P. 113724 - 113724
Published: Dec. 18, 2021
Depression
has
become
one
of
the
most
commonly
prevalent
neuropsychiatric
disorders,
and
main
characteristics
depression
are
sleep
disorders
melatonin
secretion
caused
by
circadian
rhythm
disorders.
Abnormal
endogenous
alterations
can
contribute
to
occurrence
development
depression.
However,
molecular
mechanisms
underlying
this
abnormality
remain
ambiguous.
The
present
review
summarizes
antidepressant
effects
melatonin,
which
is
related
its
functions
in
regulation
hypothalamic-pituitary-adrenal
axis,
inhibition
neuroinflammation,
oxidative
stress,
alleviation
autophagy,
upregulation
neurotrophic,
promotion
neuroplasticity
levels
neurotransmitters,
etc.
Also,
receptor
agonists,
such
as
agomelatine,
ramelteon,
piromelatine,
tasimelteon,
GW117,
have
received
considerable
critical
attention
highly
implicated
treating
comorbid
This
focuses
on
various
agonists
pathophysiology
treatment
depression,
aiming
provide
further
insight
into
pathogenesis
explore
potential
targets
for
novel
agent
development.
