Insufficient Evidence to Recommend Shu Mian Capsule in Managing Depression With or Without Comorbid Insomnia: A Systematic Review With Meta-Analysis and Trial Sequential Analysis DOI Creative Commons

Fei-Yi Zhao,

Peijie Xu, Gerard A. Kennedy

et al.

Neuropsychiatric Disease and Treatment, Journal Year: 2025, Volume and Issue: Volume 21, P. 167 - 183

Published: Jan. 1, 2025

This systematic review with trial sequential analysis (TSA) aims to evaluate the efficacy and safety of Shu Mian Capsule (SMC), a commercial Chinese polyherbal preparation, for managing depression or without comorbid insomnia. Controlled clinical trials assessing SMC against waitlist control, placebo active controls, as an adjunct treatment were searched across seven databases. Risk bias evidence quality assessed using Cochrane criteria GRADE framework, respectively. Fourteen studies analyzed, involving 1207 participants. Trials comparing standard antidepressive treatments limited. In depressed patients insomnia, combining antidepressants reduced incidence antidepressants-induced sleep disorders (from 12.2% 3.8%) but did not significantly lower Hamilton Rating Scale Depression (HAM-D) scores compared alone [SMD = -0.09, 95% CI (-0.32, 0.14), p 0.45]. combination psychotropic drugs HAM-D -1.29, (-1.96, -0.62), < 0.01] Pittsburgh Sleep Quality Index -1.53, (-1.95, -1.11), 0.01], exhibited various drug-related adverse effects alone. TSA validated sample size adequacy; nevertheless, methodological supporting varied from very low due substantial risk. Additionally, 92.9% lacked follow-ups. The effectiveness alternative conventional is unclear. For adding care demonstrates augmented improved safety, though methodologically Further rigorous are warranted confirm SMC's short-term explore its medium- long-term either complementary therapy. Current precludes recommendations administration in depression.

Language: Английский

Glycosides of Buyang Huanwu decoction inhibits inflammation associated with cerebral ischemia-reperfusion via the PINK1/Parkin mitophagy pathway DOI

Keyan Jiao,

Zhuiwen Lai, Qiaochu Cheng

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 325, P. 117766 - 117766

Published: Jan. 22, 2024

Language: Английский

Citations

7
Advancements in research on the immune-inflammatory mechanisms mediated by NLRP3 inflammasome in ischemic stroke and the regulatory role of natural plant products DOI Creative Commons
Kailin Yang,

Liuting Zeng,

Qi He

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: March 27, 2024

Ischemic stroke (IS) is a major cause of mortality and disability among adults. Recanalization blood vessels to facilitate timely reperfusion the primary clinical approach; however, itself may trigger cerebral ischemia-reperfusion injury. Emerging evidence strongly implicates NLRP3 inflammasome as potential therapeutic target, playing key role in ischemia The aberrant expression function inflammasome-mediated inflammation have garnered considerable attention recent research focus. Accordingly, this review provides comprehensive summary signaling pathways, pathological mechanisms, intricate interactions involving inflammasomes Moreover, notable progress has been made investigating impact natural plant products (e.g., Proanthocyanidins, methylliensinine, salidroside, α-asarone, acacia, curcumin, morin, ginsenoside Rd, paeoniflorin, breviscapine, sulforaphane, etc.) on regulating by modulating mitigating release inflammatory cytokines. These findings aim present novel insights that could contribute prevention treatment

Language: Английский

Citations

7
Paeoniae radix rubra:A review of ethnopharmacology, phytochemistry, pharmacological activities, therapeutic mechanism for blood stasis syndrome, and quality control DOI
Zuowang Fan, Jing Liu, Xu Wang

et al.

Chemistry & Biodiversity, Journal Year: 2024, Volume and Issue: 21(8)

Published: June 8, 2024

Paeoniae Radix Rubra (PRR) known as Chishao, in China, is the dried root of Paeonia lactiflora Pall. or veitchii Lynch, with a history over 2000 years traditional Chinese medicine, employed to clear heat, cool blood, dispel blood stasis, and alleviate pain. Phytochemical investigations identified 264 compounds that contained monoterpenes their glycosides, sesquiterpenes, triterpenes, steroids, flavonoids, lignans, tannins, volatile oils, other compounds. It has been reported have different pharmacological activities, including cardiovascular-protective, antidepressive, neuroprotective, antitumor, hepatoprotective, anti-inflammatory effects. This study offers comprehensive review covering ethnopharmacology, phytochemistry, therapeutic mechanism for stasis syndrome, quality control PRR. The analysis aims achieve thorough understanding its effects serves foundation future research development.

Language: Английский

Citations

7
Parkin, a Parkinson's disease-associated protein, mediates the mitophagy that plays a vital role in the pathophysiology of major depressive disorder DOI
Yi Zhang

Neurochemistry International, Journal Year: 2024, Volume and Issue: 179, P. 105808 - 105808

Published: July 22, 2024

Language: Английский

Citations

7
Targeting autophagy to counteract neuroinflammation: A novel antidepressant strategy DOI Creative Commons
Hua Gan, Qingyu Ma, Wenzhi Hao

et al.

Pharmacological Research, Journal Year: 2024, Volume and Issue: 202, P. 107112 - 107112

Published: Feb. 23, 2024

Depression is a common disease that affects physical and mental health imposes considerable burden on afflicted individuals their families worldwide. associated with high rate of disability suicide. It causes severe decline in productivity quality life. Unfortunately, the pathophysiological mechanisms underlying depression have not been fully elucidated, risk its treatment still presented. Studies shown expression autophagic markers brain peripheral inflammatory mediators are dysregulated depression. Autophagy-related genes regulate level autophagy change response related to several aspects immunity. The regulation immune system inflammation by may lead development or deterioration disorders. This review highlights role neuroinflammation pathophysiology depression, sumaries autophagy-targeting small moleculars, discusses novel therapeutic strategy based anti-inflammatory target treat disease.

Language: Английский

Citations

6
Antioxidant effects of Paeoniflorin and relevant molecular mechanisms as related to a variety of diseases: A review DOI Open Access

Yansong Lu,

Lu Yin, Wei Yang

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 176, P. 116772 - 116772

Published: May 28, 2024

Paeoniflorin (PF), which is the main component of Paeonia lactiflora Pall extract, one traditional Chinese medicines. The pharmacological effects associated with PF include antioxidant, immunomodulatory, anti-inflammatory, anticancer, antidepressant-like and neuroprotective effects. Our previous studies had revealed that protected melanocytes inhibited photodamage through suppression oxidative stress (OS). As OS plays a vital role in progression variety diseases, capacity for to suppress may exert important upon them. However, no review exists on these antioxidant as related various diseases. Therefore, this we summarized involved examining molecular mechanisms PF. Through its inhibit OS, has been shown beneficial several systems including nervous, cardiac/vascular, digestive, respiratory well specific diseases such diabetes, autoimmune, pregnancy related, ocular, kidney, dermatology, along distal flap necrosis, postoperative adhesions, hearing loss. Such findings provide new insights directions future research directed at development natural treatment clinical

Language: Английский

Citations

6
Antidepressant effects of the traditional Chinese herbal formula Xiao-Yao-San and its bioactive ingredients DOI
Yating Wang, Xiaole Wang, Zhen‐Zhen Wang

et al.

Phytomedicine, Journal Year: 2022, Volume and Issue: 109, P. 154558 - 154558

Published: Nov. 21, 2022

Language: Английский

Citations

25
Integrating Metabolomics and Network Analysis for Exploring the Mechanism Underlying the Antidepressant Activity of Paeoniflorin in Rats With CUMS-Induced Depression DOI Creative Commons
Chaofang Lei, Zhigang Chen, Lili Fan

et al.

Frontiers in Pharmacology, Journal Year: 2022, Volume and Issue: 13

Published: June 13, 2022

Background: Paeoniflorin (PF) represents the major bioactive constituent of traditional Chinese medicine plant Paeonia suffruticosa (Ranunculaceae), which has a long history as folk in Asian. Paeoniflorin, bitter pinene monoterpene glycoside, antidepressant effects, but its potential therapeutic mechanism not been thoroughly explored. Methods: Experimental depression rats was established by chronic unpredictable mild stress (CUMS) combined with orphan method, and efficacy paeoniflorin on evaluated sucrose preference test open field test. The investigated metabolomic network pharmacology. relevant pathways biomarkers highlighted metabolomics were explored, possible targets treatment further revealed through analysis. binding activity to key verified molecular docking. Results: Metabolomics showed that CUMS-induced had urine metabolic disorders, reversed regulation pathways. Metabolites play role function include citric acid, thiamine monophosphate, gluconolactone, 5-hydroxyindoleacetic acid stachyose. Key predicted are SLC6A4, TNF, IL6 SLC6A3. An important pathway is Citrate cycle (TCA cycle). Conclusion: Network integrative analysis this study could improve depressive-like symptoms model overall correct disordered profile multiple

Language: Английский

Citations

24
Can Natural Products Targeting EMT Serve as the Future Anticancer Therapeutics? DOI Creative Commons
Sirajudheen Anwar, Jonaid Ahmad Malik,

Sakeel Ahmed

et al.

Molecules, Journal Year: 2022, Volume and Issue: 27(22), P. 7668 - 7668

Published: Nov. 8, 2022

Cancer is the leading cause of death and has remained a big challenge for scientific community. Because growing concerns, new therapeutic regimens are highly demanded to decrease global burden. Despite advancements in chemotherapy, drug resistance still major hurdle successful treatment. The primary should be identifying developing appropriate therapeutics cancer patients improve their survival. Multiple pathways dysregulated cancers, including disturbance cellular metabolism, cell cycle, apoptosis, or epigenetic alterations. Over last two decades, natural products have been research interest due potential various ailments. Natural compounds seem an alternative option management. substances derived from plants marine sources shown anti-cancer activity preclinical settings. They might proved as sword kill cancerous cells. present review attempted consolidate available information on underlying EMT mechanisms.

Language: Английский

Citations

23
Mechanisms of paeoniaceae action as an antidepressant DOI Creative Commons

Wanxu Guo,

Xiaoxiao Yao, Ranji Cui

et al.

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 13

Published: Feb. 8, 2023

Paeoniflorin (PF) has been widely used for the treatment of depression in mice models, some Chinese herbal compound containing PF on treating depression, such as Xiaoyao San, Chaihu-Shugan-San, Danggui Shaoyao San etc. Many experiments are also verifying whether these powders can be an effective component depression. Therefore, this review antidepressant effect and its mechanism action outlined with particular focus following aspects: increasing levels monoamine neurotransmitters, inhibiting HPA axis, promoting neuroprotection, enhancing neurogenesis hippocampus, elevating brain-derived neurotrophic factor (BDNF). This may helpful application

Language: Английский

Citations

15