Acne vulgaris: advances in pathogenesis and prevention strategies

European Journal of Clinical Microbiology & Infectious Diseases, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

Language: Английский

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Simultaneous Quantification and Validation of Triterpenoids and Phytosterols in Plant Extracts, Foods, and Nutraceuticals using HPLC-DAD

Journal of Food Composition and Analysis, Journal Year: 2025, Volume and Issue: unknown, P. 107418 - 107418

Published: Feb. 1, 2025

Language: Английский

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Antimicrobial and antiparasitic potential of lupeol: antifungal effect on the Candida parapsilosis species complex and nematicidal activity against Caenorhabditis elegans

Journal of Medical Microbiology, Journal Year: 2025, Volume and Issue: 74(3)

Published: March 7, 2025

Introduction. There is growing concern about infections caused by non-albicans Candida species, including species of the parapsilosis complex - which have seen a considerable increase in cases during COVID-19 pandemic addition to nematode resistance currently used anthelmintics.Gap Statement. Lupeol triterpenoid phytosterol that has wide range biological activities, although its antifungal and antiparasitic potential still poorly explored. Additionally, effect on biofilm C. not yet been studied.Aim. This study aimed investigate lupeol against planktonic cells mature biofilms, as well nematicidal Caenorhabditis elegans. In addition, molecular docking was performed identify target molecules for lupeol's effect.Methodology. Twelve strains were used. Planktonic susceptibility through broth microdilution assay, while antibiofilm investigated measuring biomass metabolic activity. The mechanism action fishing. evaluation using elegans infection model.Results. demonstrated activity with MIC between 64 512 µg ml-1. able reduce starting from concentration 1024 ml-1 It observed there interaction enzyme 14α-demethylase. Furthermore, had ml-1.Conclusion. exhibits an complex, forms, possibly affecting ergosterol synthesis. further potential.

Language: Английский

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Betulonic acid: A review on its sources, biological activities, and molecular mechanisms

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177518 - 177518

Published: March 1, 2025

Language: Английский

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The Role of Triterpenoids in Gastric Ulcer: Mechanisms and Therapeutic Potentials

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3237 - 3237

Published: March 31, 2025

Gastric ulcer (GU) is a prevalent gastrointestinal disorder impacting millions worldwide, with complex pathogenic mechanisms that may progress to severe illnesses. Conventional therapies relying on anti-secretory agents and antibiotics are constrained by drug abuse increased bacterial resistance, highlighting the urgent need for safer therapeutic alternatives. Natural medicinal compounds, particularly triterpenoids derived from plants herbs, have gained significant attention in recent years due their favorable efficacy reduced toxicity profiles. Emerging evidence indicates exhibit potent anti-ulcer properties across various experimental models, modulating key pathways involved inflammation, oxidative stress, apoptosis, mucosal protection. Integrating current knowledge of these bioactive compounds facilitates development natural triterpenoids, addresses challenges clinical translation, deepens mechanistic understanding GU pathogenesis, drives innovation strategies GU. This review comprehensively evaluates research treatment since 2000, discussing biological sources, structural characteristics, pharmacological activities, action, animal models employed studies, limitations, associated application.

Language: Английский

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Edible pentacyclic triterpenes: A review of their sources, bioactivities, bioavailability, self-assembly behavior, and emerging applications as functional delivery vehicles

Critical Reviews in Food Science and Nutrition, Journal Year: 2022, Volume and Issue: 64(16), P. 5203 - 5219

Published: Dec. 8, 2022

Edible pentacyclic triterpenes (PTs) are a group of nutraceutical ingredients commonly distributed in human diets. Existing evidence has proven that they have various biological functions, including anticancer, antioxidant, anti-inflammatory and hypoglycemic activities, making them as "functional factor" for long time. However, their properties strong hydrophobicity, poor permeability, absorption, rapid metabolism result low oral bioavailability, which dramatically hinders efficacy use. Recently, free PTs successively been found to self-assemble or co-assemble into self-contained nanostructures with enhanced water dispersibility seems be an efficient processing method increased efficacy. Of particular interest, formulating can also introduced functional delivery carriers bioactive compounds drugs advantages, such improved stability, controlled release, synergistic bioactivity, targeted delivery. This review systematically summarized the chemical structures, plant sources, bioactivities, metabolism, bioavailability PTs. Notably, we emphasized self-assembly emerging role nutrients, suggesting PT not only forms when foods but materials nutrients expand commercial food applications.

Language: Английский

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Protective effects of lupeol in rats with renal ischemia‑reperfusion injury

Experimental and Therapeutic Medicine, Journal Year: 2024, Volume and Issue: 28(2)

Published: June 7, 2024

Acute kidney injury (AKI) caused by ischemia and, exogenous or endogenous nephrotoxic agents poses a serious health issue. AKI is seen in 1% of all hospital admissions, 2‑5% hospitalizations and 67% intensive care unit (ICU) patients. The in‑hospital mortality rates for 40‑50, >50% ICU Ischemia‑reperfusion (I/R) the can activate inflammatory responses oxidative stress, resulting AKI. common endpoint acute tubular necrosis cellular insult secondary to direct toxins, which results effacement brush border, cell death decreased function cells. aim present study was assess if reported antioxidant anti‑inflammatory agent lupeol exert any effects against renal I/R damage. In total, 24 Wistar Albino rats were randomly assigned into four groups 6, namely Sham, lupeol, therapy groups. group, intraperitoneal administration 100 mg/kg given 1 h before laparotomy, whilst only laparotomy conducted sham group. arteries both kidneys clamped 45 min, after either saline injection (in group) application group). blood samples tissues collected h. samples, urea nitrogen (BUN) measured urease enzymatic method, creatinine kinetic Jaffe method. Using ELISA TNF‑α IL‑6 levels whereas malondialdehyde (MDA), glutathione (GSH), caspase‑3 tissues. addition, histopathological analysis performed evaluating degree degeneration, dilatation, interstitial lymphocyte infiltration, protein cylinders, loss borders. It determined that damage occurred due higher BUN, creatinine, MDA, values observed group compared with Sham Compared those exhibited increased GSH reduced TNF‑α, MDA. Furthermore, also had scores. Although differences not statistically significant, they markedly treatment Taken together, these findings suggest prevent as mainly evidenced scores, stress markers. These properties may allow be used

Language: Английский

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Lupeol-3-carbamate Derivatives: Synthesis and Biological Evaluation as Potential Antitumor Agents

Molecules, Journal Year: 2024, Volume and Issue: 29(17), P. 3990 - 3990

Published: Aug. 23, 2024

In the following study, a series of new lupeol-3-carbamate derivatives were synthesized, and structures all newly derived compounds characterized. The screened to determine their anti-proliferative activity against human lung cancer cell line A549, liver HepG2, breast MCF-7. Most found show better in vitro than lupeol. Among them, obvious anti-proliferation (IC50 = 5.39~9.43 μM) was exhibited by compound 3i three tumor lines. addition, salt reaction performed on 3k 13.98 it observed that water solubility 3k·CH3I 3.13 μM), significantly enhanced subsequent formation process. preliminary mechanistic studies demonstrated apoptosis HepG2 cells induced through inhibition PI3K/AKT/mTOR pathway. conclusion, synthesized via structural modification C-3 site lupeol, thus laying theoretical foundation for design this anticancer drug.

Language: Английский

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In-depth analysis of lupeol: delving into the diverse pharmacological profile

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 13, 2024

Lupeol, a naturally occurring lupane-type pentacyclic triterpenoid, is widely distributed in various edible vegetables, fruits, and medicinal plants. Notably, it found high concentrations plants like Tamarindus indica , Allanblackia monticola Emblica officinalis among others. Quantitative studies have highlighted its presence Elm bark, Olive fruit, Aloe leaf, Ginseng oil, Mango pulp, Japanese Pear bark. This compound synthesized from squalene through the mevalonate pathway can also be synthetically produced lab, addressing challenges natural product synthesis. Over past four decades, extensive research has demonstrated lupeol’s multifaceted pharmacological properties, including anti-inflammatory, antioxidant, anticancer, antibacterial effects. Despite significant therapeutic potential, clinical applications of lupeol been limited by poor water solubility bioavailability. Recent advancements focused on nano-based delivery systems to enhance bioavailability, development derivatives further amplified bioactivity. review provides comprehensive overview latest understanding benefits lupeol. It discusses innovative strategies improve thereby enhancing efficacy. The aim consolidate current knowledge stimulate into potential derivatives.

Language: Английский

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Effect of betulinic acid on MepA efflux pump inhibition in Staphylococcus aureus: Antibacterial and molecular study

Steroids, Journal Year: 2025, Volume and Issue: unknown, P. 109572 - 109572

Published: Feb. 1, 2025

Language: Английский

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