Molecular Medicine, Journal Year: 2024, Volume and Issue: 30(1)
Published: Dec. 20, 2024
Language: Английский
Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14
Published: June 27, 2023
Aging is an inevitable process influenced by genetics, lifestyles, and environments. With the rapid social economic development in recent decades, proportion of elderly has increased rapidly worldwide, many aging-related diseases have shown upward trend, including nervous system diseases, cardiovascular metabolic cancer. The rising burden become urgent global health challenge requires immediate attention solutions. Natural products been used for a long time to treat various human diseases. primary cellular pathways that mediate longevity-extending effects natural involve nutrient-sensing pathways. Among them, sirtuin, AMP-activated protein kinase, mammalian target rapamycin, p53, insulin/insulin-like growth factor-1 signaling are most widely studied. Several studies reviewed individual compounds on aging along with underlying mechanisms. from food sources, such as polyphenols, saponins, alkaloids, polysaccharides, classified antiaging promote prolong life via In this article, we several recently identified potential properties highlighted their molecular discovery use dietary supplements can prevent multiple humans will be beneficial. Thus, review provides theoretical background existing agents.
Language: Английский
Citations
28
Food Bioscience, Journal Year: 2024, Volume and Issue: 61, P. 104695 - 104695
Published: July 4, 2024
Language: Английский
Citations
4
Human Genetics, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 8, 2025
Refractive error (RE) and myopia are complex polygenic conditions with the majority of genome-wide associated genetic variants in non-exonic regions. Given this, onset during childhood, gene-regulation is expected to play an important role its pathogenesis. This prompted us explore beyond traditional gene finding approaches. We performed a association study between non-coding RNAs enhancers, RE myopia. obtained single-nucleotide polymorphisms (SNPs) microRNA (miRNA) genes, miRNA-binding sites, long genes (lncRNAs) enhancers from publicly available databases: miRNASNPv2, PolymiRTS, VISTA Enhancer Browser, FANTOM5 lncRNASNP2. investigated whether SNPs overlapping these elements were leveraged large GWAS meta-analysis (N = 160,420). With risk scores (GRSs) per element, we joint effect on RE, axial length (AL)/corneal radius (CR), AL progression independent child cohort, Generation R Study 3638 children). constructed score for biological plausibility SNP highly confident sites chromatin accessible found that two miRNA 14 81 lncRNA regions 54 myopia-associated loci. GRSs significantly AL/CR progression. lncRNAs all miRNAs not any ocular biometric measurement. showed suggestive but inconsistent significance. prioritized candidate binding future functional validation. Pathways target host ranked included eye development (BMP4, MPPED2), neurogenesis (DDIT4, NTM), extracellular matrix (ANTXR2, BMP3), photoreceptor metabolism (DNAJB12), morphogenesis (CHDR1), neural signaling (VIPR2) TGF-beta (ANAPC16). first large-scale Enhancers could be importance as they childhood provide blueprint validation by prioritizing enhancers.
Language: Английский
Citations
0
Survey of Ophthalmology, Journal Year: 2025, Volume and Issue: unknown
Published: March 1, 2025
Language: Английский
Citations
0
Food Bioscience, Journal Year: 2023, Volume and Issue: 56, P. 103322 - 103322
Published: Nov. 2, 2023
Language: Английский
Citations
8
Journal of Translational Medicine, Journal Year: 2023, Volume and Issue: 21(1)
Published: June 20, 2023
Although the executive pathways of senescence are known, underlying control mechanisms diverse and not fully understood, particularly how cancer cells avoid triggering despite experiencing exacerbated stress conditions within tumor microenvironment.Mass spectrometry (MS)-based proteomic screening was used to identify differentially regulated genes in serum-starved hepatocellular carcinoma RNAi employed determine knockdown phenotypes prioritized genes. Thereafter, gene function investigated using cell proliferation assays (colony-formation, CCK-8, Edu incorporation cycle) together with cellular (SA-β-gal, SAHF SASP). Gene overexpression techniques were applied examine mRNA protein regulation combination luciferase reporter proteasome degradation assays, respectively. Flow cytometry detect changes reactive oxygen species (ROS) vivo examined a xenograft model.Among induced by serum deprivation, NIPSNAP1 selected for investigation. Subsequent experiments revealed that promotes inhibits P27-dependent induction via dual mechanisms. Firstly, maintains levels c-Myc sequestering E3 ubiquitin ligase FBXL14 prevent proteasome-mediated turnover c-Myc. Intriguingly, restrained transcriptional repression mediated c-Myc-Miz1, lifted response withdrawal, thus identifying feedback between Secondly, shown modulate ROS promoting interactions deacetylase SIRT3 superoxide dismutase 2 (SOD2). Consequent activation SOD2 serves maintain below critical required induce cycle arrest senescence. Importantly, actions preventing recapitulated models.Together, these findings reveal as an important mediator negative regulator These also provide theoretical basis therapy where targeting invokes
Language: Английский
Citations
7
Environmental Toxicology, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 13, 2024
ABSTRACT Age‐related macular degeneration (AMD), a leading cause of blindness, is characterized by mitochondrial dysfunction retinal pigment epithelium (RPE) cells. EUK‐134 mimetic SOD2 and catalase, widely used for its antioxidant properties in models light‐induced damage or oxidative stress. However, effects on the retina are not yet clear. Here, we investigated capability averting AMD using sodium iodate (NaIO 3 )‐induced Balb/c mouse ARPE‐19 cells (adult RPE cell line). In vivo, effectively antagonized NaIO ‐induced deformation prevented outer inner nuclear layer thinning. addition, it was found that EUK‐134‐treated group significantly down‐regulated expression cleaved caspase‐3 compared with treated alone. Our results notably improved viability preventing ROS accumulation‐induced membrane potential depolarization‐mediated apoptosis ‐inducted Furthermore, could inhibit p‐ERK, p‐p38, p‐JNK, p‐p53, Bax, caspase‐9, caspase‐3, PARP increasing Bcl‐2 protein expression. Additionally, employed MAPK pathway inhibitors SB203580 (a p38 inhibitor), U0126 (an ERK SP600125 JNK inhibitor) to corroborate aforementioned observation. The support may prevent stress‐mediated retinopathy.
Language: Английский
Citations
2
GeroScience, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 5, 2024
Language: Английский
Citations
2
Free Radical Biology and Medicine, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 1, 2024
Language: Английский
Citations
2
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(14), P. 11554 - 11554
Published: July 17, 2023
Ninjurin 1 (NINJ1) is a double-transmembrane cell-surface protein that might mediate plasma membrane rupture (PMR) and the diffusion of inflammatory factors. PMR characteristic acinar cell injury in severe acute pancreatitis (SAP). However, involvement NINJ1 mediating cells SAP currently unclear. Our study has shown expressed cells, expression significantly upregulated sodium-taurocholate-induced SAP. The knockout delays alleviates Moreover, we observed mediated by Ca2+ concentration cells. Importantly, found overload drives mitochondrial stress to upregulate P53/NINJ1 pathway, inducing amlodipine, channel inhibitor, can reduce occurrence decreasing Ca2+. results demonstrate mechanism which induces provide potential new target for treatment
Language: Английский
Citations
6