Network pharmacology, molecular docking, and experimental verification reveal the mechanism of San-Huang decoction in treating acute kidney injury DOI Creative Commons
Jiahui Liu, Zhongtang Li,

Yunlan Lao

et al.

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: Feb. 6, 2023

Background: Cisplatin is an effective anti-tumor drug. However, its usage constrained by side effects such as nephron toxicity. Cisplatin-induced acute kidney injury (AKI) appears in approximately 20%-30% of cases. Hence, finding protective strategy necessary. San-Huang decoction (SHD) a Chinese herbal with good efficacy treating chronic disease (CKD). Nevertheless, the mechanism SHD on AKI remains unclear. Consequently, we proposed to explore potential against cisplatin-induced AKI. Methods: Active compounds, core target proteins, and associated signaling pathways were predicted through network pharmacology. Then confirmed molecular docking. In vivo experiment, + group was treated (6.5 g/kg/day) for 6 days before building model. An model established single intraperitoneal injection cisplatin at 20 mg/kg. After 72 h injection, all mice sacrificed collect blood tissues verification pharmacology analysis. Results: We found that calycosin, rhein, ginsenoside Rh2 may be SHD's primary active compounds AKI, AKT, TNF-α, IL-6, IL-1β, caspase-3, MMP9 are proteins. The relationship between compound protein further Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) pathway analyses has anti-inflammatory role TNF IL-17 pathway. Moreover, Western blot immunohistochemistry validated mechanisms SHD, from involves apoptosis inflammation. apoptosis, Caspase-3, caspase-8, caspase-9, Bax proteins down-regulated, while Bcl-2 up-regulated SHD. differential expression MMP involved pathological process protects glomerular tubule damage. PI3K/AKT anti-apoptosis addition, discovered alleviated inhibiting NF-κB Conclusion: plays critical anti-inflammation via activating pathway, indicating candidate drug investigation

Language: Английский

Wound-Healing Effects of Curcumin and Its Nanoformulations: A Comprehensive Review DOI Creative Commons
Amrita Kumari, Neha Raina, Abhishek Wahi

et al.

Pharmaceutics, Journal Year: 2022, Volume and Issue: 14(11), P. 2288 - 2288

Published: Oct. 25, 2022

Wound healing is an intricate process of tissue repair or remodeling that occurs in response to injury. Plants and plant-derived bioactive constituents are well explored the treatment various types wounds. Curcumin a natural polyphenolic substance has been used since ancient times Ayurveda for its properties, as it reduces inflammation acts on several stages. Several research studies curcumin delivery at wound site reported effectiveness eradicating reactive oxygen species ability enhance deposition collagen, granulation formation, finally, expedite contraction. widely investigated potential but lower solubility rapid metabolism, addition shorter plasma half-life, have limited applications healing. As nanotechnology proven be effective technique accelerate by stimulating appropriate mobility through phases, curcumin-loaded nanocarriers targeted sites. This review highlights nanoformulations, such liposomes, nanoparticles, nano-emulsions, etc. paper emphasizes numerous biomedical which collectively prepare base antibiofilm wound-healing action.

Language: Английский

Citations

113
Curcumin: Overview of Extraction Methods, Health Benefits, and Encapsulation and Delivery Using Microemulsions and Nanoemulsions DOI Open Access
Maria D. Ciuca, Radu C. Racoviţă

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(10), P. 8874 - 8874

Published: May 17, 2023

Curcumin is the principal curcuminoid found in rhizomes of turmeric. Due to its therapeutic action against cancer, depression, diabetes, some bacteria, and oxidative stress, it has been used widely medicine since ancient times. low solubility, human organism cannot completely absorb it. Advanced extraction technologies, followed by encapsulation microemulsion nanoemulsion systems, are currently being improve bioavailability. This review discusses different methods available for curcumin from plant material, identification resulting extracts, beneficial effects on health, techniques into small colloidal systems that have over past decade deliver this compound.

Language: Английский

Citations

46
Curcumin modulated gut microbiota and alleviated renal fibrosis in 5/6 nephrectomy-induced chronic kidney disease rats DOI Creative Commons
Li Cheng, Xulong Chen, Jingchun Yao

et al.

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(1), P. e0314029 - e0314029

Published: Jan. 9, 2025

Increasing evidence suggests that dysbiosis of gut microbiota exacerbates chronic kidney disease (CKD) progression. Curcumin (CUR) has been reported to alleviate renal fibrosis in animal models CKD. However, the relationship between CUR and microbiome CKD remains unclear. This study aims investigate potential anti-renal effects from perspective. A 5/6 nephrectomy (5/6Nx) rat model was used explore therapeutic effect on fibrosis. Tight junction protein expression levels were measured assess intestinal barrier function. 16S rRNA sequencing employed evaluate changes composition, metabolomics utilized detect alterations plasma metabolites. The administration significantly ameliorated inhibited inflammation 5/6Nx rats. Additionally, markedly improved tight proteins local colon inflammation. also positively reconstructed microbiota, increasing abundance beneficial bacteria, such as Lachnospiraceae_NK4A136_group , Eubacterium_siraeum_group Muribaculaceae increased. Metabolomics revealed reduced uremic retention solutes elevated Vitamin D short-chain fatty acids (SCFAs). Spearman correlation analysis indicated genera enriched by correlated with SCFA negatively injury biomarkers. Mechanistically, we found inhibition LPS/TLR4/NF-κB TGF-β1/Smads pathway CUR-treated Our indicates modulate this modulation may contribute anti-fibrosis CUR.

Language: Английский

Citations

2
New insight into oxidative stress and inflammatory responses to kidney stones: Potential therapeutic strategies with natural active ingredients DOI Open Access
Yue Sun,

Hongmei Sun,

Zhengze Zhang

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 179, P. 117333 - 117333

Published: Sept. 8, 2024

Language: Английский

Citations

10
Multiple mechanisms of curcumin targeting spinal cord injury DOI Creative Commons
Guangjin Gu, Jie Ren, Bin Zhu

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 159, P. 114224 - 114224

Published: Jan. 14, 2023

Spinal cord injury (SCI) is an irreversible disease process with a high disability and mortality rate. After primary spinal injury, the secondary may occur in sequence, which composed of ischemia hypoxia, excitotoxicity, calcium overload, oxidative stress inflammation, resulting massive death parenchymal cells injured area, followed by formation syringomyelia. Effectively curbing can promote nerve repair improve functional prognosis. As main active ingredient turmeric, curcumin play important role reducing inflammation oxidation, protecting neurons, ultimately injury. This article reviews effects on emphasis various mechanisms promotes treatment

Language: Английский

Citations

17
Network pharmacology and experimental validation to investigate the mechanism of Nao-Ling-Su capsule in the treatment of ischemia/reperfusion-induced acute kidney injury DOI

Yong-Qiang Lin,

Lili Xu, Huibin Lin

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 326, P. 117958 - 117958

Published: Feb. 22, 2024

Language: Английский

Citations

8
Nanodelivery System of Traditional Chinese Medicine Bioactive Compounds: Application in the Treatment of Prostate Cancer DOI Creative Commons
Bo Zou, Yan Long,

Rui‐Song Gao

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 135, P. 155554 - 155554

Published: March 29, 2024

The long history of clinical experience in China have confirmed the effectiveness traditional Chinese medicine (TCM) treating prostate cancer (PCa). Until now, several bioactive compounds with anti-PCa potential, such as curcumin, gallic acid, and quercetin, been extracted from TCM. Recent studies shown that encapsulating these TCM into nano-delivery system enhanced their bioavailability improved ability to target PCa tumors.

Language: Английский

Citations

8
Preclinical evidence of reno-protective effect of quercetin on acute kidney injury: a meta-analysis of animal studies DOI Creative Commons
Yifan Zeng, Jingyu Li, Xinyu Wei

et al.

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: Dec. 22, 2023

Objective: This study evaluated the reno-protective effects of quercetin in animal models acute kidney injury (AKI). Methods: We conducted a systematic search literature published before April 2023 PubMed, Web Science, and EMBASE databases. Methodological quality was assessed by SYRCLE’s RoB tool. Funnel plot, Egger’s test, Begg’s test were used to determine publication bias. Results: A total 19 studies with 288 animals included this meta-analysis. The methodology scores ranged from 4 7. results indicated that reduced blood urea nitrogen (SMD = −4.78; 95% CI: 6.45, −3.12; p < 0.01; I 2 84%) serum creatinine (SMD: 2.73, 3.66, −1.80; 80%) AKI models. result sensitivity analysis stable, while funnel plot asymmetric. In addition, we further analyzed inflammatory cytokines, oxidative stress levels, scores, found treatment had antioxidant anti-inflammatory improved AKI. Conclusion: Quercetin exhibited promising effect Systematic Review Registration: PROSPERO (CRD42023433333).

Language: Английский

Citations

15
Nanosystems for oxidative stress regulation in the anti-inflammatory therapy of acute kidney injury DOI Creative Commons
Yue Wang, Hong Jiang, Longyao Zhang

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2023, Volume and Issue: 11

Published: Feb. 9, 2023

Acute kidney injury (AKI) is a clinical syndrome that results from rapid decline in renal structure or functional impairment with the main pathological feature of sublethal and lethal damage to tubular cells. However, many potential therapeutic agents cannot achieve desired effect because their poor pharmacokinetics short retention time kidneys. With recent emergence progress nanotechnology, nanodrugs unique physicochemical properties could prolong circulation time, enhance efficient targeted delivery, elevate accumulation therapeutics can cross glomerular filtration barrier indicate comprehensive application prospects prevention treatment AKI. In this review, various types nanosystems (such as liposomes, polymeric nanosystems, inorganic nanoparticles cell-derived extracellular vesicles) are designed applied improve drug formation, which further relieve burden on kidneys caused by final cumulative dose drugs conventional treatments. Moreover, passive active targeting also reduce total off-target adverse effects other organs. Nanodelivery systems for treating AKI alleviate oxidative stress-induced cell regulate inflammatory microenvironment summarized.

Language: Английский

Citations

14
Cisplatin Nephrotoxicity: Novel Insights Into Mechanisms and Preventative Strategies DOI
Shveta S. Motwani,

Sharneet Sandhu Kaur,

Abhijat Kitchlu

et al.

Seminars in Nephrology, Journal Year: 2022, Volume and Issue: 42(6), P. 151341 - 151341

Published: Nov. 1, 2022

Language: Английский

Citations

20