Synaptic plasticity and neuroprotection: The molecular impact of flavonoids on neurodegenerative disease progression

Neuroscience, Journal Year: 2025, Volume and Issue: 569, P. 161 - 183

Published: Feb. 7, 2025

Language: Английский

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Engineered Macrophage Membrane‐Coated Nanoparticles with Enhanced CCR2 Expression Promote Spinal Cord Injury Repair by Suppressing Neuroinflammation and Neuronal death

Small, Journal Year: 2023, Volume and Issue: 20(10)

Published: Oct. 26, 2023

Abstract Spinal cord injury (SCI) is a severe neurological disorder characterized by significant disability and limited treatment options. Mitigating the secondary inflammatory response following initial primary focus of current research in SCI. CCL2 (C─C motif chemokine ligand 2) serves as regulator responsible for chemotaxis majority peripheral immune cells, blocking CCL2‐CCR2 receptor type axis has shown considerable therapeutic potential diseases, including In this study, it presents multifunctional biomimetic nanoplatform (CCR2‐MM@PLGA/Cur) specifically designed to target axis, which consisted an engineered macrophage membrane (MM) coating with enhanced CCR2 expression PLGA (poly (lactic‐co‐glycolic acid)) nanoparticle that encapsulated drugs. overexpression on MM not only drug‐targeted delivery site, but also attenuated infiltration, microglia pro‐inflammatory polarization, neuronal apoptosis trapping CCL2. Consequently, facilitated neural regeneration motor function recovery SCI mice, enabling comprehensive approach The feasibility efficacy platform are confirmed through series vitro vivo assays, offering new insights avenues further exploration

Language: Английский

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Advances in molecular therapies for targeting pathophysiology in spinal cord injury

Expert Opinion on Therapeutic Targets, Journal Year: 2023, Volume and Issue: 27(3), P. 171 - 187

Published: March 4, 2023

Introduction Spinal cord injury (SCI) affects 25,000–50,000 people around the world each year and there is no cure for SCI patients currently. The primary damages spinal tissues secondary mechanisms, including ischemia, apoptosis, inflammation, astrogliosis, further exacerbate lesions to cord. Recently, researchers have designed various therapeutic approaches by targeting its major cellular or molecular pathophysiology.Areas covered Some strategies shown promise in repairing injured functional recoveries, such as administering neuroprotective reagents, specific genes promote robust axon regeneration of disconnected fiber tracts, epigenetic factors enhance cell survival neural repair, facilitating neuronal relay pathways neuroplasticity restoration function after SCI. This review focuses on advances preclinical therapies reported recent years.Expert opinion Recent progress developing novel effective encouraging, but many challenges remain future design treatments, highly neuroprotectants early interventions, stimulating with synaptic reconnections among neurons, maximizing recovery lost functions combination strategies, translating most promising into human use.

Language: Английский

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Pharmacological intervention of curcumin via the NLRP3 inflammasome in ischemic stroke

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: Oct. 17, 2023

Ischemic-induced neuronal injury arises due to low oxygen/nutrient levels and an inflammatory response that exacerbates loss. NOD-like receptor family pyrin domain-containing 3 (NLRP3) is important regulator of inflammation after ischemic stroke, with its inhibition being involved in nerve regeneration. Curcumin, a main active ingredient Chinese herbs, plays positive role repair neuroprotection by regulating the NLRP3 signaling pathway. Nevertheless, mechanisms relating how curcumin regulates inflammasome neural restoration following stroke are unknown. In this report, we summarize biological functions along neuroprotective effects underlying via impairment pathway brain injury. We also discuss medicinal interventions target potential pathways, as well possible directions for therapy penetrate blood-brain barrier (BBB) hinder stroke. This report conclusively demonstrates has properties inhibit prevent cell loss, thereby delaying progression damage.

Language: Английский

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Pyroptosis in Spinal Cord Injury: Implications for Pathogenesis and Therapeutic Approaches

Frontiers in Bioscience-Landmark, Journal Year: 2024, Volume and Issue: 29(6), P. 210 - 210

Published: June 11, 2024

Traumatic spinal cord injury (SCI) is a serious disease of the central nervous system. Aside from limited intrinsic regenerative capacity neurons, complex microenvironmental disturbances can also lead to further cellular damage and growth inhibition. Programmed cell death regulated by pyroptosis has an important role in pathogenesis SCI. While there been wealth new knowledge regarding pyroptosis, detailed understanding its SCI possible therapeutic strategies still lacking. This review summarizes current advances regulatory pyroptosis-regulated inflammasome components inhibitory microenvironment following SCI, as well recent advances.

Language: Английский

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A biomimic anti-neuroinflammatory nanoplatform for active neutrophil extracellular traps targeting and spinal cord injury therapy

Materials Today Bio, Journal Year: 2024, Volume and Issue: 28, P. 101218 - 101218

Published: Aug. 24, 2024

Traumatic spinal cord injury (SCI) always leads to severe neurological deficits and permanent damage. Neuroinflammation is a vital process of SCI have become promising target for treatment. However, the neuroinflammation-targeted therapy would hinder functional recovery lead treatment failure. Herein, biomimic anti-neuroinflammatory nanoplatform (DHCNPs) was developed active neutrophil extracellular traps (NETs) targeting The curcumin-loaded liposome with anti-inflammatory property acted as core DHCNPs. Platelet membrane were fused form hybrid DHCNPs hijacking neutrophils neutralizing elevated neutrophil-related proinflammatory cytokines, respectively. DNAse I modification on could achieve NETs degradation, blood barrier, neuron repair. Further studies proved that reprogram multifaceted neuroinflammation reverse via nuclear factor kappa-B (NF-κB) pathway. We believe current study provides new perspective inhibition may shed light SCI.

Language: Английский

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PEG-SH-GNPs-SAPNS@miR-29a delivery system promotes neural regeneration and recovery of motor function after spinal cord injury

Journal of Biomaterials Science Polymer Edition, Journal Year: 2023, Volume and Issue: 34(15), P. 2107 - 2123

Published: June 27, 2023

Spinal cord injury (SCI) is a serious disease characterized by hemorrhage, edema, local ischemia and hypoxia, inflammatory reaction, degeneration of the injured spinal cord, which lacks effective clinical treatments. We design PEG-SH-GNPs-SAPNS@miR-29a delivery system to repair impaired building regenerative microenvironment for recruitment endogenous neural stem cells. The miR-29a, as an axonal regeneration-related miRNA that overexpression miR-29a significantly inhibits expression PTEN promotes regeneration cord. gold nanoparticles self-assembling peptide hydrogel composite scaffold (PEG-SH-GNPs-SAPNS@miR-29a system) applied deliver recruit cells simultaneously. Sustained release give rise favorable recovery motor function after injury. These findings suggest may be alternative strategy treatment SCI.

Language: Английский

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Rehabilitation training enhanced the therapeutic effect of calycosin on neurological function recovery of rats following spinal cord injury

Journal of Chemical Neuroanatomy, Journal Year: 2023, Volume and Issue: 136, P. 102384 - 102384

Published: Dec. 29, 2023

Language: Английский

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Curcumin nanoparticles in heat stroke management

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Sept. 12, 2024

Language: Английский

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Microenvironment Self‐Adaptive Nanomedicine Promotes Spinal Cord Repair by Suppressing Inflammation Cascade and Neural Apoptosis

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 31, 2024

Abstract Despite various biomaterial‐based strategies are tried in spinal cord injury (SCI), developing safe and effective microinvasive pharmacotherapy is still an unmet clinical need. Stimuli‐responsive nanomedicine has emerged as a promising non‐invasion technology, which enhances drug delivery promotes functional recovery following SCI. Considering the multiple progressive pathological events blood barrier (BSCB) associating SCI, microenvironment self‐adaptive nanoparticle (custom‐designed with rabies virus glycoprotein 29‐RVG29 hyaluronic acid‐HA, RHNP) capable of consistently crossing BSCB selectively targeting inflammatory cells neural based on different stages SCI developed. The data indicated that RHNP can effectively traverse through RVG29, adaptively modulate cellular internalization by exposing either HA or RVG29 diselenide bonds, depending reactive oxygen species (ROS) signals. Furthermore, curcumin loaded into (RHNP‐Cur) to improve motor function coordination hind‐limbs traumatic mouse model. This study finds RHNP‐Cur exhibited inhibitory effects cascade originating from M1 microglia/macrophages neurotoxic astrocytes, protected inflammation‐induced apoptosis during nerve regeneration. Collectively, work provides enables efficient treatment

Language: Английский

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