Frontiers in Pharmacology,
Journal Year:
2023,
Volume and Issue:
14
Published: Jan. 30, 2023
Background:
The
treatment
of
hypertensive
nephropathy
has
remained
unchanged
for
many
years.
Salvianolate
is
the
main
active
component
extracted
from
Salvia
Miltiorrhiza.
current
studies
seem
to
suggest
that
salvianolate
a
certain
therapeutic
effect
on
nephropathy.
Objective:
purpose
this
meta-analysis
evaluate
and
safety
under
condition
standardized
use
valsartan.
Methods:
We
conducted
systematic
search
(unlimited
initial
date
22
October
2022)
in
PubMed,
Web
Science,
Cochrane
Library,
Embase,
China
National
Knowledge
Infrastructure,
Wanfang
Data
knowledge
service
platform,
Science
Technology
Journal
Database,
Biomedical
Literature
Service
System.
Searching
study
Two
reviewers
independently
included
met
inclusion
criteria,
data,
evaluated
quality
study.
RevMan5.4
stata15
software
meta-analysis.
GRADEprofiler
3.2.2
evidence
assessment.
Results:
This
seven
(525
patients).
Compared
with
valsartan
combined
conventional
treatment,
can
further
improve
efficacy
(RR
=
1.28,
95%CI:1.17
1.39),
reduce
blood
pressure
[systolic
(MD
8.98,
95%CI:-12.38
-5.59);
diastolic
5.74,
95%CI:-7.20
-4.29)],
serum
creatinine
-17.32,
95%CI:-20.55
-14.10),
urea
nitrogen
-1.89,
95%CI:-3.76
-0.01),
urine
microalbumin
-23.90,
95%CI:-26.54
-21.26),
urinary
protein
ratio
-1.92,
95%CI:-2.15
-1.69),
cystatin
C
-1.04,
95%CI:
-1.63
-0.45)
increase
calcitonin
gene-related
peptide
18.68,
95%CI:12.89
24.46)
without
increasing
adverse
reactions
2.20,
95%CI:0.52
9.40).
But
it
no
additional
endothelin-1
malondialdehyde.
ranged
moderate
very
low.
Conclusion:
shows
renal
function
patients
based
was
used.
Therefore,
be
used
as
clinical
supplement
However,
not
high
due
uneven
insufficient
sample
size,
we
still
need
lot
large
size
more
perfect
design
confirm
these
results.
Systematic
Review
Registration:
https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022373256,
identifier
CRD42022373256.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(6), P. 1201 - 1201
Published: March 7, 2024
As
one
of
the
traditional
Chinese
herbs,
Danshen
(Salvia
miltiorrhiza
Bunge)
has
been
widely
studied
and
used
in
treatment
cardiovascular,
cerebrovascular,
other
immune
diseases.
Tanshinones
salvianolic
acids
isolated
from
are
considered
to
be
main
components
its
biological
activity
pharmacology
that
play
important
roles
increasing
index
organs,
regulating
number
function
cells,
releasing
immunoreactive
substances.
Especially
tanshinone
IIA,
cryptotanshinone,
acid
B,
rosmarinic
show
good
treating
rheumatoid
arthritis,
some
immune-mediated
inflammatory
diseases,
psoriasis,
bowel
disease.
In
order
understand
their
pharmacological
effects
provide
references
for
future
research
clinical
treatment,
regulation
response
by
tanshinones
is
summarized
detail
this
paper.
addition,
challenges
development
opportunities
exploit
potential
have
documented.
Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
15
Published: Jan. 13, 2025
The
pathogenesis
of
renal
fibrosis
is
related
to
blood
stasis,
and
the
method
promoting
circulation
removing
stasis
often
used
as
treatment
principle.
Danshen
injection
(DSI)
a
commonly
drug
for
in
clinic.
However,
whether
DSI
slows
progression
or
potential
mechanism
uncertain.
We
investigated
models
using
UUO
mice
TGF-β
stimulation
HK-2
cells.
Our
findings
revealed
that
Fer-1
alleviated
kidney
injury
by
ameliorating
morphology
pathological
vivo.
Besides,
inhibited
vivo
TGF-β-induced
Furthermore,
ferroptosis
was
lessened
under
treatment.
More
importantly,
active
ingredients
(danshensu,
salvianolic
acid
B,
protocatechuic
aldehyde,
caffeic
tanshinone
IIA)
could
bind
SIRT1.
protein
levels
SIRT1
GPX4
were
downregulated
accompanied
incremental
concentrations
Erastin,
which
repaired
intervention.
inhibition
owing
reversed
inhibitor
EX527.
Taken
together,
our
results
indicated
protect
against
attenuate
activating
SIRT1/GPX4
pathway.
It
expected
be
agent
treat
fibrosis.
European Journal of Pharmaceutical Sciences,
Journal Year:
2024,
Volume and Issue:
196, P. 106759 - 106759
Published: April 1, 2024
Xuebijing
injection
(XBJ)
is
widely
used
to
treat
nephrotic
syndrome
(NS)
in
clinic,
but
its
bioactive
components
and
therapeutic
mechanism
are
still
unclear.
In
this
study,
the
of
XBJ
were
determined
by
ultra-performance
liquid
chromatography
quadrupole
time-of-flight
tandem
mass
spectrometry
(UPLC-Q-TOF/MS).
The
effect
on
NS
was
evaluated
BALB/c
mice
induced
adriamycin
(ADR,
10
mg/kg)
via
a
single
tail
vein.
protective
podocytes
demonstrated
using
mouse
(MPC-5)
lipopolysaccharide
(LPS,
4
μg/mL).
results
show
that
33
identified.
Furthermore,
12
detected
blood,
including
protocatechuic
acid,
salvianolic
acid
C,
benzoyloxypaeoniflorin,
danshensu,
A,
B,
catechin,
caffeic
galloylpaeoniflorin,
oxypaeoniflorin,
hydroxysafflor
yellow
rosmarinic
acid.
relative
content
(%)
59.32,
16.01,
9.97,
9.73,
8.72,
8.31,
7.92,
6.54,
1.54,
1.30,
0.68
0.59
order.
After
treatment,
renal
function,
hyperlipidemia
pathological
damage
improved
model
mice.
Moreover,
levels
nephrin
desmin
which
functional
proteins
reversed,
pro-inflammatory
factors
reduced
XBJ.
Interestingly,
C
also
showed
good
effects
podocyte
function
level
inflammation
LPS-induced
MPC-5.
study
first
time
elucidate
potential
for
treating
protecting
function.
Materials Today Bio,
Journal Year:
2025,
Volume and Issue:
31, P. 101589 - 101589
Published: Feb. 21, 2025
Osteoarthritis
(OA)
is
the
most
common
chronic
inflammatory
joint
disease.
Improving
microenvironment
expected
to
promote
early
intervention
and
delay
progression
of
OA.
However,
effective
strategies
for
inhibiting
OA-related
inflammation
are
still
lacking.
Lithospermic
acid
(LA),
a
polycyclic
phenol
carboxylic
extracted
from
salvia
miltiorrhiza,
has
strong
anti-inflammatory
antioxidant
effects.
its
role
in
treatment
OA
underlying
mechanisms
unclear.
To
improve
bioavailability
LA,
an
LA
synergistic
protects
etched
zeolitic
imidazolate
framework
(ZIF)-8
nanoparticles
(LA@ZIF-8)
was
designed
developed
targeted
delivery
modulate
This
study
confirmed
that
LA@ZIF-8
inhibits
pro-inflammatory
phenotype
RAW264.7
macrophages
through
NF-ĸB
signaling
pathway,
effectively
alleviates
mitochondrial
dysfunction,
delays
articular
cartilage
degeneration
caused
by
mediated
synoval
macrophages.
In
summary,
synovial
macrophage-mediated
responses,
highlighting
clinical
application
potential.
BMC Nephrology,
Journal Year:
2025,
Volume and Issue:
26(1)
Published: April 18, 2025
Heavy
proteinuria
is
an
important
hallmark
for
kidney
disease
including
nephrotic
syndrome.
Astragali
Radix,
a
traditional
Chinese
herb,
holds
the
potential
to
alleviate
syndrome;
however,
underlying
mechanism
has
not
been
completely
clarified.
The
study
aimed
explore
role
of
calycosin
(C16H12O5),
major
active
component
in
regulating
adriamycin-induced
proteinuria.
A
rat
model
syndrome
was
established
through
two
adriamycin
injections
within
weeks
(4
mg/kg
first
week
and
2
second
week).
After
induction
renal
injury,
10
or
20
intraperitoneally
injected
into
rats
four
weeks.
Before
euthanasia
rats,
urine
blood
samples
were
collected,
body
weight
recorded.
Then,
24
h
protein
content,
index,
total
cholesterol
(TC),
triglyceride
(TG),
as
well
function
indicators
urea
nitrogen
(BUN),
serum
creatinine
(SCR),
albumin
excretory
rate
(UAE)
measured.
Hematoxylin-eosin
staining
cortex
tissues
performed
evaluate
glomerular
structural
damage.
TUNEL
assay
cell
apoptosis.
Western
blotting
conducted
measure
levels
podocyte-specific
markers
(podocin
nephrin),
Notch1,
Snail
tissues.
Calycosin
reversed
increase
concentrations
indicators.
ameliorated
damage,
inflammatory
infiltration,
basement
membrane
thickening
rats.
In
addition,
rescued
suppressive
impact
on
apoptosis
podocyte
markers.
activated
Notch1/Snail
signaling
suppressed
by
intervention.
exerts
protective
against
via
inhibition
signaling.
Not
applicable.