Emerging roles of N6-methyladenosine in arsenic-induced toxicity DOI Creative Commons
Rui Li,

Cuixia Wu,

Yu‐Wan Zhao

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(22), P. e40473 - e40473

Published: Nov. 1, 2024

Arsenic can cause extensive toxic damage after entering the body of humans and animals by altering a variety events. As most common form methylation modification RNA in eukaryotic cells, N

Language: Английский

New insights into zinc alleviating renal toxicity of arsenic-exposed carp (Cyprinus carpio) through YAP-TFR/ROS signaling pathway DOI

Hongmin Lu,

Yue Zhang, Xintong Zhang

et al.

Pesticide Biochemistry and Physiology, Journal Year: 2024, Volume and Issue: 205, P. 106153 - 106153

Published: Sept. 25, 2024

Language: Английский

Citations

18
Amino acid metabolism disorder and oxidative stress took part in EGCG alleviating Mn-caused ferroptosis via miR-9-5p/got1 axis DOI
Qin Zhou,

Zhiyu Hao,

Ming-Yue Qiu

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 489, P. 137656 - 137656

Published: Feb. 21, 2025

Language: Английский

Citations

4
Targeting ferroptosis: a new therapeutic opportunity for kidney diseases DOI Creative Commons
Zhiyong Long,

Yanfang Luo,

Min Yu

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: July 3, 2024

Ferroptosis is a form of non-apoptotic regulated cell death (RCD) that depends on iron and characterized by the accumulation lipid peroxides to lethal levels. involves multiple pathways including redox balance, regulation, mitochondrial function, amino acid, lipid, glycometabolism. Furthermore, various disease-related signaling also play role in regulating process oxidation. In recent years, with emergence concept ferroptosis in-depth study its mechanisms, closely associated biological conditions related kidney diseases, organ development, aging, immunity, cancer. This article reviews development ferroptosis, mechanisms (including GSH-GPX4, FSP1-CoQ1, DHODH-CoQ10, GCH1-BH4, MBOAT1/2 pathways), latest research progress involvement diseases. It summarizes diseases within frameworks metabolism, reactive oxygen biology, biology. The introduces key regulatory factors as well important concepts major open questions natural compounds. hoped future research, further breakthroughs can be made understanding regulation mechanism utilizing promote treatments for such acute injury(AKI), chronic disease (CKD), diabetic nephropathy(DN), renal carcinoma. paves way new approach prevent, treat clinical

Language: Английский

Citations

9
Ferroptosis induced by environmental pollutants and its health implications DOI Creative Commons
Fu‐Han Gong, Liyuan Liu,

Xuesheng Wang

et al.

Cell Death Discovery, Journal Year: 2025, Volume and Issue: 11(1)

Published: Jan. 24, 2025

Abstract Environmental pollution represents a significant public health concern, with the potential risks associated environmental pollutants receiving considerable attention over an extended period. In recent years, substantial body of research has been dedicated to this topic. Since discovery ferroptosis, iron-dependent programmed cell death typically characterized by lipid peroxidation, in 2012, there have advances study its role and mechanism various diseases. A growing number studies also demonstrated involvement ferroptosis damage caused organism pollutants, molecular mechanisms involved partially elucidated. The targeting be effective means ameliorating PM2.5, organic inorganic ionizing radiation. This review begins providing summary most important ferroptosis. It then proceeds offer critical analysis effects induced pollutants. Furthermore, as is case all rapidly evolving areas, are numerous unanswered questions challenges pertaining pollutant-induced which we discuss attempt provide some directions clues for future field.

Language: Английский

Citations

1
Beyond Mortality: Exploring the Influence of Plant Phenolics on Modulating Ferroptosis—A Systematic Review DOI Creative Commons
Nemanja Živanović, Marija Lesjak, Nataša Simin

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(3), P. 334 - 334

Published: March 10, 2024

Ferroptosis is a recently discovered type of programmed cell death that mechanistically different from other types such as apoptosis, necroptosis, and autophagy. It characterized by the accumulation intracellular iron, overproduction reactive oxygen species, depletion glutathione, extensive lipid peroxidation lipids in membrane. was ferroptosis interconnected with many diseases, neurodegenerative ischemia/reperfusion injury, cancer, chronic kidney disease. Polyphenols, plant secondary metabolites known for bioactivities, are being extensively researched context their influence on which resulted great number publications showing need systematic review. In this review, an literature search performed. Databases (Scopus, Web Science, PubMed, ScienceDirect, Springer) were searched time span 2017 to November 2023, using keyword “ferroptosis” alone combination “flavonoid”, “phenolic acid”, “stilbene”, “coumarin”, “anthraquinone”, “chalcone”; after selection studies, we had 311 papers 143 phenolic compounds. total, 53 compounds showed ability induce ferroptosis, 110 able inhibit out those compounds, 20 both abilities depending model system. The most shikonin, curcumin, quercetin, resveratrol, baicalin. common modes action modulation Nrf2/GPX4 Nrf2/HO-1 axis iron metabolism.

Language: Английский

Citations

6
Functional metabolomics reveals arsenic-induced inhibition of linoleic acid metabolism in mice kidney in drinking water DOI
Tianmu He, Lijuan Xiong, Kexin Lin

et al.

Environmental Pollution, Journal Year: 2024, Volume and Issue: 349, P. 123949 - 123949

Published: April 16, 2024

Language: Английский

Citations

6
Cellular preconditioning and mesenchymal stem cell ferroptosis DOI
Doaa Hussein Zineldeen, Mazhar Mushtaq, Khawaja Husnain Haider

et al.

World Journal of Stem Cells, Journal Year: 2024, Volume and Issue: 16(2), P. 64 - 69

Published: Feb. 25, 2024

In this editorial, we comment on the article published in recent issue of

Language: Английский

Citations

5
Low-dose bisphenol A plus arsenite: continuous or intermittent exposures in Sprague-Dawley rats; effects on kidney oxidative stress, DNA damage, ferroptosis, and fibrosis DOI
Goutam Kumar Sahoo, Asit K. Pattnaik, Vinod Kumar

et al.

Mutation Research/Genetic Toxicology and Environmental Mutagenesis, Journal Year: 2025, Volume and Issue: unknown, P. 503871 - 503871

Published: April 1, 2025

Language: Английский

Citations

0
Mineralized extracellular matrix composite scaffold incorporated with salvianolic acid A enhances bone marrow mesenchymal stem cell osteogenesis and promotes calvarial bone regeneration DOI
Jiayu Chen, Qing Liu, Jifang Wan

et al.

Biomaterials Advances, Journal Year: 2025, Volume and Issue: unknown, P. 214327 - 214327

Published: April 1, 2025

Language: Английский

Citations

0
Epicatechin ameliorates glucose intolerance and hepatotoxicity in sodium arsenite-treated mice DOI

Sara Hejazi,

Mehrnoosh Moosavi, Shahrzad Molavinia

et al.

Food and Chemical Toxicology, Journal Year: 2024, Volume and Issue: 192, P. 114950 - 114950

Published: Aug. 24, 2024

Language: Английский

Citations

3