Natural Products/Bioactive Compounds as a Source of Anticancer Drugs

Cancers, Journal Year: 2022, Volume and Issue: 14(24), P. 6203 - 6203

Published: Dec. 15, 2022

Cancer is one of the major deadly diseases globally. The alarming rise in mortality rate due to this disease attracks attention towards discovering potent anticancer agents overcome its rate. discovery novel and effective from natural sources has been main point interest pharmaceutical research because attractive therapeutic with an immense chemical diversity species animals, plants, microorganisms. More than 60% contemporary drugs, form or another, have originated sources. Plants microbial are chosen based on their composition, ecology, phytochemical, ethnopharmacological properties. derivatives played a significant role producing agents. Some plant include vincristine, vinblastine, irinotecan, topotecan, etoposide, podophyllotoxin, paclitaxel. Based particular activity, number other plant-derived bioactive compounds clinical development phase against cancer, such as gimatecan, elomotecan, etc. Additionally, conjugation anti-cancerous some polymeric carriers particularly targeted epitopes site tumors, can generate treatment therapies. Cognizance studies would yield alternative drug strategies through which could be economical, more reliable, safe use.

Language: Английский

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Curcumin Formulations for Better Bioavailability: What We Learned from Clinical Trials Thus Far?

ACS Omega, Journal Year: 2023, Volume and Issue: 8(12), P. 10713 - 10746

Published: March 13, 2023

Curcumin has been credited with a wide spectrum of pharmacological properties for the prevention and treatment several chronic diseases such as arthritis, autoimmune diseases, cancer, cardiovascular diabetes, hemoglobinopathies, hypertension, infectious inflammation, metabolic syndrome, neurological obesity, skin diseases. However, due to its weak solubility bioavailability, it limited potential an oral medication. Numerous factors including low water solubility, poor intestinal permeability, instability at alkaline pH, fast metabolism contribute curcumin's bioavailability. In order improve different formulation techniques coadministration piperine, incorporation into micelles, micro/nanoemulsions, nanoparticles, liposomes, solid dispersions, spray drying, noncovalent complex formation galactomannosides have investigated in vitro cell culture models, vivo animal humans. current study, we extensively reviewed clinical trials on various generations curcumin formulations their safety efficacy many We also summarized dose, duration, mechanism action these formulations. critically advantages limitations each compared placebo and/or available standard care therapies ailments. The highlighted integrative concept embodied development next-generation helps minimize bioavailability issues least or no adverse side effects provisional new dimensions presented this direction may add value cure

Language: Английский

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Curcumin, inflammation, and neurological disorders: How are they linked?

Integrative Medicine Research, Journal Year: 2023, Volume and Issue: 12(3), P. 100968 - 100968

Published: June 25, 2023

Despite the extensive research in recent years, current treatment modalities for neurological disorders are suboptimal. Curcumin, a polyphenol found Curcuma genus, has been shown to mitigate pathophysiology and clinical sequalae involved neuroinflammation neurodegenerative diseases.We searched PubMed database relevant publications on curcumin its uses treating diseases. We also reviewed trials which appeared searching using 'Curcumin trials'.This review details pleiotropic immunomodulatory functions neuroprotective properties of curcumin, derivatives formulations various preclinical investigations. The effects diseases such as Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), brain tumors, epilepsy, Huntington's disorder (HD), ischemia, Parkinson's (PD), multiple (MS), traumatic injury (TBI) with major focus associated signalling pathways have thoroughly discussed.This demonstrates can suppress spinal by modulating diverse astroglia mediated cascades, ensuring disorders.

Language: Английский

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Health promotion campaigns using social media: association rules mining and co-occurrence network analysis of Twitter hashtags

BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 7, 2025

Social media hashtags play a significant role in increasing the visibility of health information by making it easier for people to explore health-related content. Health promotion campaigns use campaign-specific disseminate messages, enabling individuals access accurate and timely resources updates. The study aims discover patterns connection between identify most influential used on Twitter American Heart Month campaigns. We collected total 73,288 tweets containing #AmericanHeartMonth January 2019 March 2023 retrieved 18,143 original tweets, 42,930 retweets, 2,519 quotes, 20,846 likes related past five adapted co-occurrence network analysis relationships association rules mining assess quality strength co-occurred hashtags. While #AmericanHeartMonth, #OurHearts, #HeartMonth central roles all hashtag networks, results indicate #OurHearts within networks. highest density has been observed quoted introducing new range such as #GoRedForWomen, #WearRedDay, #HeartDisease, #HeartHealth users, indicating positive correlation co-occurring users' engagement. measurements (Lift > 1) top 5 data subsets. employed powerful techniques that may have discussions drive engagement network. In conclusion, we recommend additional structures conjunction with heart topics improve community building effectiveness disseminating messages future contributes knowledge practice offering structured data-driven approach providing practical guidance public practitioners, professionals, organisations optimise content, targeting, messaging reach engage broader audience information.

Language: Английский

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Essential oils as green promising alternatives to chemical preservatives for agri-food products: New insight into molecular mechanism, toxicity assessment, and safety profile

Food and Chemical Toxicology, Journal Year: 2023, Volume and Issue: 183, P. 114241 - 114241

Published: Nov. 25, 2023

Language: Английский

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Curcumin-Loaded Platelet Membrane Bioinspired Chitosan-Modified Liposome for Effective Cancer Therapy

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(2), P. 631 - 631

Published: Feb. 13, 2023

Cancer is a serious threat to human health, and chemotherapy for cancer limited by severe side effects. Curcumin (CUR) commonly used natural product antitumor treatment without safety concerns. However, low bioavailability poor tumor accumulation are great obstacles its clinical application. Our previous research has demonstrated that platelet membrane-camouflaged nanoparticles can efficiently ameliorate the in vivo kinetic characteristics enhance affinity of payloads. Nevertheless, efficiency this formulation still needs be thoroughly investigated, drug release behavior limited. Herein, CUR-loaded membrane bioinspired chitosan-modified liposome (PCLP-CUR) was constructed improve CUR release. PCLP-CUR shown have long retention time, improved bioavailability, strong targeting capacity effective cellular uptake. The incorporation chitosan enabled cargoes quickly under mild acidic conditions, leading more complete favoring subsequent treatment. Both vitro investigations showed could significantly anticancer efficacy with minimal effects through biomimetic modification. In summary, developed delivery system provide promising strategy tumor-targeting therapy phytochemical delivery.

Language: Английский

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In Vivo Anti-Inflammatory and Antinociceptive Activities of Black Elder (Sambucus nigra L.) Fruit and Flower Extracts

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(4), P. 409 - 409

Published: March 23, 2024

Sambucus nigra L. (S. nigra, SN) or black elder is a traditional medicinal plant widely used worldwide for therapeutic and dietary purposes. The aim of the current study was to investigate anti-inflammatory antinociceptive activities fruit flower extracts (SNFrE SNFlE, respectively). primary polyphenol constituents in extract were flavonoids phenolic acids, while anthocyanins main components extract. SNFrE revealed pronounced dose-dependent vivo activity assessed by cotton pellet-induced granuloma test. Doses 10, 20, 50 mg/kg BW reduced weight induced rats 20.3%, 20.5%, 28.4%, respectively. At highest dose (50 BW), had significant (p < 0.01) comparable that diclofenac, reference compound (10 BW). In addition, mice estimated using acetic-acid-induced writhing Both at doses inhibited abdominal contractions acetic acid significantly comparing control group 0.01). Our findings indicate particularly possess activities, providing experimental evidence use S. medicine.

Language: Английский

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Machine Learning-Based Virtual Screening and Molecular Simulation Approaches Identified Novel Potential Inhibitors for Cancer Therapy

Biomedicines, Journal Year: 2023, Volume and Issue: 11(8), P. 2251 - 2251

Published: Aug. 11, 2023

Cyclin-dependent kinase 2 (CDK2) is a promising target for cancer treatment, developing new effective CDK2 inhibitors of great significance in anticancer therapy. The involvement tumorigenesis has been debated, but recent evidence suggests that specifically inhibiting could be beneficial treating certain tumors. This approach remains attractive the development drugs. Several small-molecule targeting have reached clinical trials, selective inhibitor yet to discovered. In this study, we conducted machine learning-based drug designing search candidate CDK2. Machine learning models, including k-NN, SVM, RF, and GNB, were created detect active inactive target. models assessed using 10-fold cross-validation ensure their accuracy reliability. These methods are highly suitable classifying compounds as either or through virtual screening extensive compound libraries. Subsequently, techniques employed analyze test dataset obtained from zinc database. A total 25 with 98% predicted against docked into CDK2’s site. Finally, three selected based on good docking score, and, along reference compound, underwent MD simulation. Gaussian naïve Bayes model yielded superior results compared other models. top hits exhibited enhanced stability compactness compound. conclusion, our study provides valuable insights identifying refining lead inhibitors.

Language: Английский

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Bioactivities of the Popular Edible Brown Seaweed Sargassum fusiforme: A Review

Journal of Agricultural and Food Chemistry, Journal Year: 2023, Volume and Issue: 71(44), P. 16452 - 16468

Published: Oct. 25, 2023

Sargassum fusiforme has a wide range of active constituents (such as polysaccharides, sterols, polyphenols, terpenes, amino acids, trace elements, etc.) and is an economically important brown algae with long history. In recent years, S. been intensively studied attracted attention in the fields agriculture, environment, medicine, functional food. this review, we reviewed current research status at home abroad over past decade by searching Web science, Google Scholar, other databases, structurally analyzed components fusiforme, on basis, focused summarizing cutting-edge scientific issues role various substances exerting antioxidant, anti-inflammatory, antitumor, antidiabetic, immunomodulatory, antiviral antibacterial, anticoagulant effects. The mechanisms which different exert effects were further summarized exploring experimental models are shown visually. It provides reference to promote development comprehensive utilization resources.

Language: Английский

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Microanalysis Characterization and Immunomodulatory Effect for Selenium-Enriched Polysaccharide from Morchella esculenta (L.) Pers.

Molecules, Journal Year: 2023, Volume and Issue: 28(7), P. 2885 - 2885

Published: March 23, 2023

Morchella esculenta (L.) Pers., referred to as Morel, is a medicinal and edible homologous fungus, which contains many bioactive substances. In polysaccharides are the most abundant have various bioactivities. present work, two novel polysaccharides, Se-MPS MPS, were prepared purified from selenium-enriched (Se-enriched) common Morel mycelia, respectively, their structural immunomodulatory properties evaluated. The results show that Se-enriched treatment significantly changed polysaccharides' chemical composition, molecular weight, sugar chain configuration. addition, also improved fragmentation thermal stability. Importantly, polysaccharide (Se-MPS) could enhance phagocytosis of RAW 264.7 macrophage cells and, remarkably, activate immune response via activating TLR4-TRAF6-MAPKs-NF-κB cascade signaling pathway, finally exerting an function. Based on these findings, appears more potential for development utilization in functional foods or medicines than ordinary polysaccharide.

Language: Английский

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