Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: July 18, 2024
Notch
signaling
pathway
is
activated
abnormally
in
solid
and
hematological
tumors,
which
perform
essential
functions
cell
differentiation,
survival,
proliferation,
angiogenesis.
The
activation
of
communication
among
other
oncogenic
pathways
heighten
malignancy
aggressiveness.
Thus,
targeting
offers
opportunities
for
improved
survival
reduced
disease
incidence.
Already,
most
attention
has
been
given
to
its
role
the
cancer
cells.
Recent
research
shows
that
natural
bioactive
compounds
can
change
molecules
are
linked
or
interact
with
pathways.
This
suggests
there
may
be
a
link
between
growth
tumors.
Here,
we
sum
up
possess
inhibitory
effects
on
human
cancers
by
impeding
preventing
crosstalk
pathways,
provoke
further
study
these
products
derive
rational
therapeutic
regimens
treatment
develop
novel
anticancer
drugs.
review
revealed
as
highly
challenging
but
promising
target
oncology.
Heliyon,
Journal Year:
2024,
Volume and Issue:
10(16), P. e35989 - e35989
Published: Aug. 1, 2024
The
WNT/β-catenin
signaling
pathway
plays
crucial
roles
in
tumorigenesis
and
relapse,
metastasis,
drug
resistance,
tumor
stemness
maintenance.
In
most
tumors,
the
is
often
aberrantly
activated.
therapeutic
usefulness
of
inhibition
has
been
reported
to
improve
efficiency
different
cancer
treatments
this
carried
out
using
methods
including
pharmacological
agents,
short
interfering
RNA
(siRNA),
antibodies.
Here,
we
review
WNT-inhibitory
effects
some
FDA-approved
drugs
natural
products
treatment
focus
on
recent
progress
WNT
inhibitors
improving
chemotherapy,
immunotherapy,
gene
therapy,
physical
therapy.
We
also
classified
these
according
their
structure
physicochemical
properties,
introduced
briefly
potential
mechanisms
inhibiting
pathway.
provides
a
comprehensive
understanding
various
therapeutics.
This
will
benefit
novel
inhibitor
development
optimal
clinical
use
signaling-related
synergistic
Ecotoxicology and Environmental Safety,
Journal Year:
2025,
Volume and Issue:
293, P. 118042 - 118042
Published: March 1, 2025
Herbal
medicine
has
become
an
area
of
growing
global
scientific
interest.
The
prime
objective
this
study
was
to
investigate
the
protective
role
Edgeworthia
gardneri
(Wall.)
Meisn
(EGM
polysaccharide)
against
carbon
tetrachloride
(CCl4)-induced
liver
injury
in
mice.
Forty-five
ICR
mice
were
randomly
divided
into
three
groups
(n
=
15):
IC,
IM,
and
IT.
IT
group
received
EGM
polysaccharide
solution
(50
mg/kg)
daily,
while
IC
IM
administered
equivalent
volume
normal
saline.
intraperitoneally
injected
with
a
mixture
CCl4
olive
oil
at
1:1
(v/v)
(2
mL/kg)
every
3
days.
Our
results
showed
that
significantly
(p
<
0.05)
reduced
pathological
hepatic
alterations
increased
index
caused
by
CCl4.
Moreover,
therapy
0.001)
levels
antioxidant
enzymes,
such
as
glutathione
peroxidase
(GSH-Px),
superoxide
dismutase
(SOD),
total
capacity
(T-AOC)
malondialdehyde
(MDA)
content
dose-dependent
manner.
Notably,
alleviated
inflammatory
cascades
evidenced
decreased
serum
interleukin-6
(IL-6),
interleukin-1β
(IL-1β),
tumor
necrosis
factor-
α
(TNF-α)
under
administration.
Furthermore,
16
s
rRNA
gene
sequencing
exhibited
abundance
probiotics
bacteria,
Unclassified_Lachnospiraceae,
pathogenic
bacterial
texas
like
Brevundimonas
Candidatus_Nitrocosmicu.
Conclusively,
protects
CCl4-induced
oxidative
stress
inflammation
alleviates
through
beneficial
gut
microbiota
modulations.
current
suggests
is
effective
agent
counteracting
damage.
Molecular and Clinical Oncology,
Journal Year:
2024,
Volume and Issue:
21(1)
Published: May 15, 2024
Wnt
signaling
is
a
highly
conserved
evolutionary
pathway
that
plays
key
role
in
regulation
of
embryonic
development,
as
well
tissue
homeostasis
and
regeneration.
Abnormalities
are
associated
with
tumorigenesis
leading
to
poor
prognosis
patients
cancer.
However,
the
pharmacological
effects
mechanisms
underlying
its
inhibition
cancer
treatment
remain
unclear.
In
addition,
potential
side
inhibiting
this
process
not
understood.
Therefore,
present
review
outlines
tumorigenesis,
metastasis,
stem
cells,
radiotherapy
resistance
tumor
immunity.
The
further
identifies
inhibitors
target
provide
novel
direction
for
treatment.
This
may
facilitate
early
application
safe
effective
drugs
targeting
clinical
settings.
An
in‑depth
understanding
improve
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: May 31, 2024
CD24
is
a
glycosylphosphatidylinositol-anchored
protein
that
expressed
in
wide
range
of
tissues
and
cell
types.
It
involved
variety
physiological
pathological
processes,
including
adhesion,
migration,
differentiation,
apoptosis.
Additionally,
has
been
studied
extensively
the
context
cancer,
where
it
found
to
play
role
tumor
growth,
invasion,
metastasis.
In
recent
years,
there
growing
interest
as
potential
therapeutic
target
for
cancer
treatment.
This
review
summarizes
current
knowledge
CD24,
its
structure,
function,
cancer.
Finally,
we
provide
insights
into
clinical
application
discuss
possible
approaches
development
targeted
therapies.
Frontiers in Pharmacology,
Journal Year:
2023,
Volume and Issue:
14
Published: April 20, 2023
Graphical
Abstract
In
this
review,
we
summerized
the
absorption,
distribution,
metabolism,
excretion
of
lenvatinib
in
clinic.
The
lastest
mechanism
and
potential
approches
to
overcome
resistance
caused
by
were
supplied.
International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 1723 - 1748
Published: Feb. 1, 2024
Given
the
unique
physiological
and
pathological
characteristics
of
lung,
direct,
inhalable
route
is
more
conducive
to
pulmonary
drug
delivery
disease
control
than
traditional
systemic
delivery,
significantly
circumventing
loss,
off-target
effects,
organ
toxicity,
etc.,
widely
regarded
as
preferred
regimen
for
delivery.However,
very
few
lung
diseases
are
currently
treated
with
inhaled
formulations,
such
asthma,
chronic
obstructive
hypertension.And
there
a
lack
appropriate
formulations
other
critical
diseases,
cancer
fibrosis,
due
fact
that
physicochemical
properties
drugs
their
pharmacokinetic
profiles
do
not
match
physiology
conventional
inhalation
devices
unable
deliver
them
specific
parts
lung.Phytochemicals
natural
origin,
wide
availability
clear
safety
profile,
hold
great
promise
preparation
improve
current
dilemma
in
treatment
diseases.In
particular,
based
on
nano-and
microparticulate
carriers
deep
tissues,
which
overcome
shortcomings
therapies
while
targeting
activity
directly
part
may
be
best
approach
change
treatment.In
this
review,
we
discuss
recent
advances
micron-carrier-based
products
represent
an
opportunity
practical
clinical
translation
products.
