Ethnopharmacological
relevance:
Cardiovascular
disease
has
become
a
common
ailment
that
endangers
human
health
and
garnered
widespread
attention
due
to
its
high
prevalence,
recurrence
rate,
sudden
death
risk.
Ginseng
possesses
functions
such
as
invigorating
vital
energy,
enhancing
vein
recovery,
promoting
body
fluid
blood
nourishment,
calming
the
nerves,
improving
cognitive
function.
It
is
widely
utilized
in
treatment
of
various
heart
conditions,
including
palpitations,
chest
pain,
failure,
other
ailments.
Although
numerous
research
reports
have
investigated
cardiovascular
activity
single
ginsenoside,
there
remains
lack
systematic
on
specific
components
group
predominantly
contribute
efficacy
ginseng
medicinal
materials.Aim
study:
To
establish
method
by
using
target
cell
extraction
HPLC/Q-TOF-MS
combined
spectral
effect
correlation
analysis
for
screening
potential
bioactive
with
protect
against
myocardial
damage
Red
Ginseng.Materials
methods:
Oxygen-glucose-deprivation
(OGD)
induced
H9c2
cells
were
used
confirm
extract
(RGE)
protection
damage.
Chromatographic
fingerprints
established
12
batches
RGE
performance
liquid
chromatography
(HPLC).
Gray
relationship
(GRA),
Partial
Least
Squares
Discrimination
Analysis
(PLA)
active
components.Results:
According
experiments,
can
improve
viability,
ATP
content
reduce
oxidative
Then,
seven
ingredients
screened
out
their
cardiovascular-activity
been
confirmed
OGD
model.Conclusion:
The
main
substance
red
treating
injury
identified,
offering
reference
quality
control
preparations
containing
management
diseases.
Phytomedicine,
Journal Year:
2024,
Volume and Issue:
unknown, P. 155357 - 155357
Published: Jan. 1, 2024
The
terminal
stage
of
all
cardiovascular
diseases
typically
culminates
in
heart
failure
(HF),
with
no
effective
intervention
available
to
halt
its
progression.
LuQi
formula
(LQF)
has
been
employed
clinical
for
numerous
years
significantly
ameliorate
cardiac
function
HF
patients.
Nevertheless,
the
underlying
mechanism
LQF's
efficacy
remains
inadequately
comprehended.
Cardiomyocyte
ferroptosis
served
as
a
pathogenic
HF.
goal
current
experiment
was
ascertain
whether
LQF
ameliorates
by
preventing
cardiomyocyte
and
elucidate
intrinsic
involved.
This
research
objective
is
investigate
impact
attenuating
failure.
Transverse
aortic
constriction
(TAC)
performed
construct
mouse
model.
Neonatal
rat
cardiomyocytes
(NRCMs)
were
subjected
vitro
experiments.
High-performance
liquid
chromatography
(HPLC)
identified
bioactive
compounds
LQF.
Transcriptomic
quantitative
proteomic
analyses
revealed
potential
targets
anti-HF.
Specifically,
histological
staining
evaluated
hypertrophy
fibrosis.
Transmission
electron
microscopy
(TEM)
observed
mitochondrial
morphology.
content
Fe2+,
ROS,
MDA,
GSH,
GSSH
detected
using
kits.
Molecular
docking
binding
activities
between
essential
active
ingredients
critical
proteins
ferroptosis.
Mechanistically,
expression
levels
Nrf2,
Keap1,
HO-1,
SLC7A11,
GPX4
qPCR,
Western
blot
(WB),
or
immunohistochemical
staining.
primary
nine
detected.
demonstrated
that
may
Histomorphometric
attenuates
myocardial
TEM
diminished
shrinkage
increased
membrane
density
tissue.
Additionally,
reactive
oxygen
species
(ROS)
generation
suppressed
Furthermore,
molecular
technique
had
suitable
GPX4,
SLC7A11.
analysis
further
verified
activated
Nrf2/GPX4
signaling
axis.
decreased
SLC7A11
HO-1
expression.
These
results
prevents
via
activating
axis
suppressing
Concurrently,
it
contributed
elucidating
provided
scientific
rationale
development
novel
therapeutic
drug.
Frontiers in Cardiovascular Medicine,
Journal Year:
2025,
Volume and Issue:
11
Published: Jan. 15, 2025
Myocardial
fibrosis
(MF)
is
a
common
pathological
manifestation
of
many
cardiovascular
diseases,
such
as
myocardial
infarction,
ischemia,
and
sudden
cardiac
death.
It
characterized
by
excessive
proliferation
activation
fibroblasts,
transformation
into
myofibroblasts,
and,
eventually,
deposition
the
extracellular
matrix,
resulting
in
heart
damage.
Currently,
modern
drugs
angiotensin-converting
enzyme
inhibitors,
diuretics,
β-blockers
can
improve
clinical
treatment,
but
their
therapeutic
effect
on
this
disease
limited,
with
obvious
side
effects
high
cost.
Traditional
Chinese
medicine
(TCM)
has
advantages
multiple
targets,
low
cost,
few
effects.
medicines,
Salvia
miltiorrhiza,
Astragalus,
Angelica
extracts,
patent
Qiliqiangxin
capsules,
Shenqi
Yiqi
dropping
pills,
Tongxinluo
fibrosis.
In
review,
current
Western
methods
for
treating
are
discussed.
The
signaling
pathways
targets
involved
treatment
This
review
aimed
to
provide
valuable
insights
ideas
both
basic
research
Frontiers in Cardiovascular Medicine,
Journal Year:
2025,
Volume and Issue:
12
Published: May 1, 2025
Cardiovascular
diseases
(CVDs)
have
become
the
leading
cause
of
death
globally,
surpassing
infectious
and
other
chronic
illnesses.
The
incidence
mortality
rates
CVDs
are
rising
worldwide,
posing
a
key
challenge
in
public
health.
ubiquitination
system
is
vast
complex.
It
an
important
post-translational
modification
that
plays
crucial
role
various
cellular
processes.
Deubiquitination
catalyzed
by
deubiquitinases
(DUBs),
which
remove
ubiquitin
(Ub)
from
ubiquitinated
proteins,
thereby
reversing
process.
DUBs
play
many
biological
processes,
such
as
DNA
repair,
cell
metabolism,
differentiation,
epigenetic
regulation,
protein
stability
control.
They
also
participate
regulation
signaling
pathways
associated
with
development
progression
CVDs.
In
this
review,
we
primarily
focus
on
pathological
mechanisms
atherosclerosis
(AS),
foam
formation,
vascular
remodeling
(VR),
endothelial-to-mesenchymal
transition
(End-MT),
clonal
hematopoiesis
(CH).
heart,
summarize
involvement
including
heart
failure
(HF),
myocardial
infarction
(MI),
hypertrophy
(MH)
ischemia/reperfusion
(I/R)
injury.
Additionally,
explore
diabetic
cardiomyopathy
(DCM)
use
doxorubicin-induced
cardiotoxicity
clinical
settings.
A
comprehensive
understanding
deubiquitination
may
provide
new
insights
for
treatment
drug
design
Biomedical Physics & Engineering Express,
Journal Year:
2024,
Volume and Issue:
10(4), P. 045001 - 045001
Published: April 19, 2024
Extracellular
vesicles
(EVs)
have
been
recognized
as
one
of
the
promising
specific
drugs
for
myocardial
infarction
(MI)
prognosis.
Nevertheless,
low
intramyocardial
retention
EVs
remains
a
major
impediment
to
their
clinical
application.
In
this
study,
we
developed
silk
fibroin/hydroxypropyl
cellulose
(SF/HPC)
composite
hydrogel
combined
with
AC16
cell-derived
targeted
modification
by
folic
acid
treatment
acute
repair.
were
functionalized
distearoylphosphatidyl
ethanolamine-polyethylene
glycol
(DSPE-PEG-FA)
via
noncovalent
interaction
targeting
and
accelerating
