Prenylated chromones and flavonoids isolated from the roots of Flemingia macrophylla and their anti-lung cancer activity DOI Creative Commons
Baolin Wang, Qinqin Wang, Renyikun Yuan

et al.

Chinese Medicine, Journal Year: 2023, Volume and Issue: 18(1)

Published: Nov. 23, 2023

The successful launch of icaritin, a therapeutic drug for liver cancer derived from Epimedium brevicornu, has provided new impetus the development prenylated flavonoids in field oncology. Flemingia macrophylla is reported to contain characteristic which can regulate p53 protein. We aimed isolate these constituents and conduct activity evaluation, structure-activity relationship, mechanism studies provide candidate compounds antitumor development.In this study, chromatographic techniques combined with spectroscopic methods were used separate, purify, identify methanol extract. cytotoxic was evaluated using an MTT assay A549 H1975 cells as model. binding between protein investigated molecular docking validated cellular thermal shift (CETSA). Western blotting (WB) employed detect expression apoptosis-related proteins cells.Chiral HPLC separation racemates 1 7 two pairs undescribed enantiomers (1a/1b 7a/7b), along eight known (2 - 9) isolated roots. Their structures elucidated by analysis, absolute configurations determined experimental calculated electronic circular dichroism data. Compounds 7, non-prenyl analogues 10 13, against human lung cell line. 5 displayed better cytotoxicity than positive control icaritin H1975, IC50 values ranging 4.50 19.83 μmol·L-1 < μmol·L-1, respectively. relationships chromone or flavonoid discussed. Molecular results demonstrated that compound 7a strong interaction WB indicated induced apoptosis increasing protein, decreasing anti-apoptotic Bcl-2, activating caspase family cells. These suggest are potential activators.This study demonstrates rich constituents, among exhibited significant served reference candidates design drugs.

Language: Английский

Elucidating tobacco smoke-induced craniofacial deformities: Biomarker and MAPK signaling dysregulation unraveled by cross-species multi-omics analysis DOI Creative Commons
Yuxin Lin, Hao Li, Shukai Zheng

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 288, P. 117343 - 117343

Published: Nov. 16, 2024

Language: Английский

Citations

22
Traditional Chinese medicine in lung cancer treatment DOI Creative Commons
Zhichao Xi,

Rongchen Dai,

Yufei Ze

et al.

Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)

Published: Feb. 26, 2025

Lung cancer remains a major global health challenge and one of the leading causes cancer-related deaths worldwide. Despite significant advancements in treatment, challenges such as drug resistance, side effects, metastasis recurrence continue to impact patient outcomes quality life. In response, there is growing interest complementary integrative approaches care. Traditional Chinese medicine (TCM), with its long history, abundant clinical experience, holistic perspective individualized approach, has garnered increasing attention for role lung prevention management. This review provides comprehensive overview advances TCM covering theoretical foundation, treatment principles, experiences evidence supporting efficacy. We also provide systematic summary preclinical mechanisms, through which impacts cancer, including induction cell death, reversal inhibition modulation immune responses. Additionally, future prospects are discussed, offering insights into expanded application integration modern address this challenging disease.

Language: Английский

Citations

1
Qingre Huayu Jianpi prescription alleviates the inflammatory transformation of colitis-associated colorectal cancer by inhibiting the IL-17RA/ACT1/NF-κB axis DOI

Yilin Duan,

Yao Lü,

Zhenglin Liu

et al.

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: 345, P. 119554 - 119554

Published: March 3, 2025

Language: Английский

Citations

1
Promoting reactive oxygen species accumulation to overcome tyrosine kinase inhibitor resistance in cancer DOI Creative Commons
Wei Lin, Xiaojun Wang,

Mingxin Diao

et al.

Cancer Cell International, Journal Year: 2024, Volume and Issue: 24(1)

Published: July 9, 2024

Abstract Background In tumor treatment, protein tyrosine kinase inhibitors (TKIs) have been extensively utilized. However, the efficacy of TKI is significantly compromised by drug resistance. Consequently, finding an effective solution to overcome resistance becomes crucial. Reactive oxygen species (ROS) are a group highly active molecules that play important roles in targeted cancer therapy including therapy. this review, we concentrate on ROS-associated mechanisms lethality tumors and strategies for regulating ROS reverse cancer. Main body Elevated levels often manifest during cancers, potentially causing organelle damage cell death, which critical success TKIs eradicating cells. it noteworthy cells might initiate pathways shield themselves from ROS-induced damage, leading Addressing challenge involves blocking these pathways, instance, NRF2-KEAP1 axis protective autophagy, promote accumulation cells, thereby resensitizing drug-resistant TKIs. Additional approaches inducing generation within providing exogenous stimulation. Conclusion pivotal eradication TKI. Harnessing widely applicable approach. Graphical

Language: Английский

Citations

5
Dual role of Nrf2 signaling in hepatocellular carcinoma: promoting development, immune evasion, and therapeutic challenges DOI Creative Commons

Lin Gan,

Weimin Wang,

Jinxiu Jiang

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 2, 2024

Hepatocellular carcinoma (HCC) is the predominant form of liver cancer and ranks as third leading cause cancer-related mortality globally. The performs a wide range tasks primary organ responsible for metabolizing harmful substances foreign compounds. Oxidative stress has crucial role in growth improvement hepatocellular (HCC). Nuclear factor erythroid 2 ( 1 )-related (Nrf2) an element that regulates transcription located cytoplasm. It controls balance redox reactions by stimulating expression many genes depend on antioxidant response elements. Nrf2 contrasting functions normal, healthy HCC. In normal liver, provides advantageous benefits, while HCC it promotes effects support survival Continuous activation been detected its advancement aggressiveness. addition, Activation may lead to immune evasion, weakening cells’ ability attack tumors thereby promoting tumor development. Furthermore, chemoresistance HCC, which considered chemotherapy medications, significantly impedes effectiveness treatment. Stress management typically accomplished activating specific signal pathways chemical variables. One important creation nuclear factor-E2-related (Nrf2). production group encode proteins protecting cells from damage. This occurs through Nrf2/ARE pathway, mechanism combating oxidative within cells.

Language: Английский

Citations

4
Soluble starch nanoparticles loaded with Gefitinib for treating lung cancer: Optimization and cytotoxicity assessment DOI
Mohammed A. Amin, Hamdoon A. Mohammed

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140369 - 140369

Published: Jan. 1, 2025

Language: Английский

Citations

0
The Hidden Potential of Solasonine: Targeting Non-Small Cell Lung Cancer (NSCLC) Metastasis Through GATM and Smad2 Pathways DOI
Cheng Hu, Jiaqi Zhang, Xiaoyu Zhuang

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: 139, P. 156455 - 156455

Published: Feb. 2, 2025

Language: Английский

Citations

0
Integrated non-targeted metabolomics and gut microbial systematic analysis the mechanism of anti-tumour activity of Poriae Cutis-derived lanostane triterpenes in vivo DOI
Shuai Yue, Xi Feng, You‐Sheng Cai

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 105978 - 105978

Published: Feb. 1, 2025

Language: Английский

Citations

0
Pedunculoside inhibits cardiomyocyte inflammatory biomarkers via Nrf2/HO-1 pathway in high glucose-induced H9c2 cells and diabetic cardiomyopathy model rats DOI Creative Commons

Yuanben Lu,

Junhu Meng, Dewen Zhu

et al.

Human & Experimental Toxicology, Journal Year: 2025, Volume and Issue: 44

Published: Feb. 1, 2025

Introduction Diabetic cardiomyopathy (DCM) is a complication of diabetes mellitus (DM) that can lead to heart failure and increase the risk mortality. Pedunculoside (PE), novel triterpenoid saponin, exhibits anti-inflammatory anti-oxidative stress (OS) properties. However, its role in DCM remains unexplored. Methods models were established treated with PE or Nrf2 inhibitor (ML385). In vitro, cell function was evaluated using CCK-8, flow cytometry, qRT-PCR, ELISA. vivo, fasting blood glucose insulin levels rats measured. The effects on assessed HE staining, TUNEL corresponding kits. Additionally, Nrf2/HO-1 pathway proteins analyzed by western blot. Results Low doses (2.5, 5, 10, 20 μM) did not affect viability H9c2 cells. (10 improved prevented apoptosis, inflammation, OS high (HG)-stimulated also upregulated nucleus enhanced HO-1 NQO1 expression HG-treated Furthermore, (ML385) reversed PE’s protective HG-induced injury. reduced glucose, increased insulin, alleviated myocardial injury, inhibited decreased inflammatory factors OS, Nrf2, HO-1, model rats. Discussion alleviates injury activating pathway. These findings support potential therapeutic application DCM.

Language: Английский

Citations

0
Nrf2 in human cancers: biological significance and therapeutic potential DOI
Yu Tian, Lixin Tang, Xin Wang

et al.

American Journal of Cancer Research, Journal Year: 2024, Volume and Issue: 14(8), P. 3935 - 3961

Published: Jan. 1, 2024

The nuclear factor-erythroid 2-related factor 2 (Nrf2) is able to control the redox balance in cells responding oxidative damage and other stress signals. Nrf2 upregulation can elevate levels of antioxidant enzymes support against death. In spite protective function physiological conditions, stimulation cancer has been favour tumorigenesis. Since dysregulation molecular pathways mutations/deletions are common tumors, be a promising therapeutic target. overexpression prevent cell death tumor by increasing survival rate cells, ensures carcinogenesis. Moreover, induction promote invasion metastasis cells. stimulates EMT increase metastasis. Furthermore, regarding Nrf2, its triggers chemoresistance. natural products regulate therapy reverse drug resistance. nanostructures specifically target signaling therapy. current review discusses potential proliferation, Then, capacity for suppressing Nrf2-mediated progression discussed.

Language: Английский

Citations

2